Pyrimidine derivatives and herbicide containing the same

ABSTRACT

Disclosed are pyrimidine derivatives of the formula (I) and optical isomers thereof and a herbicide containing one or more of them as an active ingredient. ##STR1## where W is O or S; X is a lower alkyl group or a lower alkoxycarbonyl group; R is H, an optionally substituted lower alkyl group, an optionally substituted lower alkenyl group, an optionally substituted lower alkynyl group, an alkyali metal, an alkaline earth metal or an optionally substituted ammonium cation; R 1  and R 2  each are a halogen atom, an optionally substituted lower alkyl group or an optionally substituted lower alkoxy group; n is 3 to 5; m is 0 to 2; and   is a single bond or a double bond.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to novel pyrimidine derivatives andoptical isomers thereof as well as to a herbicide containing one or moreof the said derivatives as an active ingredient.

2. Description of the Prior Art

Hitherto, it is generally said that the economic cost in the use of aherbicide depends upon the necessary amount of the active ingredient inthe herbicide to be applied to a unit area, and therefore, developmentof a novel herbicide which displays a sufficient herbicidal effect evenin a small amount to be used is desired.

It is known that some conventional herbicides would often have a badinfluence on crops when applied thereto. Accordingly, studies have beeneffected for a long period of time for the purpose of obtainingcompounds which may display a high herbicidal effect even in a smallamount to be used and which may also display a high selectivity betweenthe crops to be protected and the harmful weeds to be destroyed.

For instance, Japanese Patent Laid open No. 54-55729 illustrates aherbicide containing a pyrimidine nucleus-having compound as an activeingredient.

SUMMARY OF THE INVENTION

The present inventors have studied for many years and, as a result, havefound that the pyrimidine derivatives of the formula (I) (mentionedbelow) of the present invention as well as the optical isomers thereofhave an extremely higher herbicidal activity than any other knownherbicides and additionally have found that some of the pyrimidinederivatives and the optical isomers thereof of the present inventionhave a selectivity to crops of rice, corn, wheat, soybean, cotton, beet,etc. and therefore are practically useful and that they have anexcellent herbicidal activity to harmful weeds of Echinochoa crus galli,Digitaria adscendens, Cyperus microiria, Solanum nigrum, Galinsogaciliate, Rorippa indica, Scirpus juncoides, Monochoria vagnalis, Rotalaindica, Sagittaria pygmaca, etc. Accordingly, the inventors haveachieved the present invention on the basis of such finding

Specifically, where the pyrimidine derivatives and the optical isomersthereof of the present invention are employed as the active ingredientof a herbicide, the amount of the active ingredient to be applied to aunit area may be extremely reduced, as compared with the case of usingknown herbicidal compounds. Accordingly, the chemical injury of theherbicide of the present invention to crops is extremely smaller thanthat of the known herbicides; and the economic effect in the use of theherbicide of the present invention is extremely large.

Further, the pyrimidine derivatives and the optical isomers thereof ofthe present invention are helpful for noticeably reducing the danger ofenvironmental pollution to be caused by application of a large amount ofthe herbicide to farming lands. In addition, the herbicide containingsuch derivatives or isomers thereof of the present invention is anepochal herbicide, as it does not remain in the soil and does not haveany bad influence on the crops.

Precisely, the present invention provides pyrimidine derivatives of ageneral formula (I): ##STR2## where

W represents an oxygen atom or a sulfur atom;

X represents a lower alkyl group or a lower alkoxycarbonyl group;

R represents a hydrogen atom; a lower alkyl group optionally substitutedby substituent(s) selected from a halogen atom, a lower alkoxy group ora lower alkylthio group, or a phenyl group optionally substituted by ahalogen atom, a lower alkyl group, a lower alkoxy group or a loweralkylthio group; a lower alkenyl group optionally substituted bysubstituent(s) selected from a halogen atom, a lower alkoxy group or alower alkylthio group, or a phenyl group optionally substituted by ahalogen aotm, a lower alkyl group, a lower alkoxy group or a loweralkylthio group; a lower alkynyl group optionally substituted bysubstituent(s) selected from a halogen atom, a lower alkoxy group or alower alkylthio group, or a phenyl group optionally substituted by ahalogen atom, a lower alkyl group, a lower alkoxy group or a loweralkylthio group; an alkali metal; an alkaline earth metal; or anoptionally substituted ammonium cation;

R₁ and R₂ may be same or different and each represents a halogen atom; alower alkyl group optionally substituted by substituent(s) selected froma halogen atom, a lower alkoxy group or a lower alkylthio group; or alower alkoxy group optionally substituted by substituent(s) selectedfrom a halogen atom, a lower alkoxy group or a lower alkylthio group;

n represents an integer of from 3 to 5;

m represents an integer of from 0 to 2; and

represents a single bond or a double bond;

as well as optical isomers of the said derivatives.

The present invention further provides a herbicide containing one ormore of the pyrimidine derivatives and the optical isomers thereof asthe active ingredient.

The pyrimidine derivatives and the optical isomers thereof of thepresent invention are novel compounds which are unknown up to thepresent and these have an excellent herbicidal acitivity and are usefulas a herbicide

BRIEF DESCRIPTION OF THE INVENTION

The pyrimidine derivatives of the formula (I) and the optical isomersthereof of the present invention can be prepared by reacting a cyclicalcohol or cyclic thioalcohol of a general formula (II): ##STR3## whereW, X, R, n, m and have the same meanings as defined above, with apyrimidine compound of a general formula (III) ##STR4## where

R₃ represents a halogen atom, an alkylsulfonyl group or an optionallysubstituted benzylsulfonyl group; and R₁ and R₂ have the same meaningsas defined above, in any desired proportion. Preferably, one mol of thecyclic alochol or cyclic thioalcohol of the formula (II) is blended withone mol of the pyrimidine compound of the formula (III) and these arereacted in a solvent optionally in the presence of a base.

Where the cyclic alcohol or cyclic thioalcohol of the formula (II) has adouble bond, it may be in the form of a ketoenol tautomer.

As the solvent usable in the reaction, there are mentioned, for example,hydrocarbon solvents such as benzene, toluene or xylene; halogenatedhydrocarbon solvents such as methylene chloride or chloroform; alcoholsolvents such as methyl alcohol, ethyl alcohol or isopropyl alcohol;ether solvents such as diethyl ether, diisopropyl ether, tetrahydrofuranor 1,4-dioxane; ketone solvents such as acetone or methyl ethyl ketone;ester solvents such as methyl acetate or ethyl acetate; aprotonicsolvents such as dimethylformamide, dimethylacetamide ordimethylsulfoxide; and acetonitrile and water.

As the base also usable in the reaction, there are mentioned, forexample, alkali metals such as sodium metal or potassium metal; alkalimetal or alkaline earth metal hydrides such as sodium hydride or calciumhydride; carbonates such as sodium carbonate or potassium carbonate;metal hydroxides such as sodium hydroxide or potassium hydroxide; andorganic bases such as triethylamine or pyridine.

The reaction may be carried out at any desired temperature fallingwithin the range of from the solidifying point of the sovlent used tothe boiling point thereof, preferably from 0° C. to the boiling point ofthe solvent used. If desired, the reaction may be effected with heatingor cooling.

The reaction time may be from several minutes to several hours,preferably from 0.5 to 36 hours.

The pyrimidine derivatives or the optical isomers thereof of the presentinvention as prepared by the above-mentioned method can optionally bepurified by recrystallization or column chromatography, if desired.

The present invention will be explained in more detail by way of thefollowing examples, which, however, are not intended to restrict thescope of the present invention.

EXAMPLE 1 Preparation of Compound No 1 ##STR5##

Sodium hydride (5 mmol) was added to 20 ml of hexamethylphosphoric acidtriamide solution containing 0.71 g (5 mmol) of methyl2-oxocyclopentanecarboxylate and stirred for 30 minutes at roomtemperature.

Next, 1.1 g of 2-methylsulfonyl-4,6-dimethoxypyridine was added theretoand stirred for further 2 hours at 80° C. After cooled, the solvent wasremoved by distillation under reduced pressure. Water was added to theresidue, which was then extracted with ethyl acetate.

The ethyl acetate extract was then washed with water and dried, thesolvent was removed by distillation under reduced pressure. Accordignly,a brown oily product was obtained. This was purified by fractionatingthin-layer column chromatography to obtain 0.2 g of the above-entitledcompound (No. 1) as a pale yellow liquid. The compound had the followingphysical data:

n_(D) ²⁰ 1.5303.

¹ H-NMR [δ Value (ppm), CDCl₃ ] 1.70˜2.30(m, 2H), 2.50˜2.90 (m, 4H), 3.57(s, 3H), 3.82 (s, 6H)5.67(s, 1H).

EXAMPLE 2 Preparation of Compound No. 2 (Trans-form): ##STR6##

1.4 g (10 mmol) of methyl 2-hydroxycyclopentanecarboxylate and 2.0 g(9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolvedin 50 ml of absolute tetrahydrofuran, and 0.5 g of sodium hydride (50%oily) was added thereto and stirred overnight. The finish of thereaction was confirmed by high-performance liquid chromatography, andthe reaction mixture was poured into ice-water. This was extracted withethyl acetate, the organic layer was dried over anhydrous sodiumsulfate, and the solvent was removed by distillation. The resultingresidue was purified by column chromatography (silica gel-chloroform),and 2.3 g of a colorless viscous liquid was obtained. Yield: 81.6%. Thiswas subjected to fractionating thin-layer chromatography (Art 5717manufactured by Merk Co.; kieserite gel 60F₂₅₄), whereupon the liquidwas developed with a developer of chloroform/ethyl acetate (10/1) and afraction having a higher Rf value was fractionated from the eluted twocomponents. Accordingly, 1.2 g of the compound No. 2 of the inventionwas obtained. This was a colorless viscous liquid and had the followingphysical data:

n_(D) ²⁰ 1.590.

¹ H-NMR [δ Value (ppm), CDCl₃ ] 1.71˜2.36(6H, m) 2.86˜3.20(1H,m), 3.66(3H, s), 3.89(6H, s), 5.65(1H, d,J=3.96 Hz), 5.69(1H, s).

EXAMPLE 3 Preparation of Compound No. 3 (Cis-form): ##STR7##

The same process as in Example 2 was carried out, and a fraction havinga lower Rf value was fractionated from the two components. Accordingly,0.91 g of the compound No. 3 of the invention was obtained. This was acolorless viscous liquid and had the following physical data:

n_(D) ²⁰ 1.5081.

¹ H-NMR [δ Value (ppm) CDCl₃ ] 1.42˜2.37(6H,m), 2.83˜3.11 (1H, m), 3.54(3H, s), 3.89(6H, s), 5.67(1H, d, J=5.50 Hz), 5.67(1H, s).

EXAMPLE 4 Preparation of Compound No. 4: ##STR8##

1.6 g (10 mmol) of methyl 1-methyl-2-hydroxycyclopentanecarboxylate and2.0 g (9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine weredissolved in 50 ml of absolute tetrahydrofuran, and 0.5 g of 50 % oilysodium hydride was added thereto and stirred overnight. The finish ofthe reaction was confirmed by high-performance liquid chromatography,and the reaction mixture was poured into ice-water. This was extractedwith ethyl acetate, the organic layer was dried over anhydrous sodiumsulfate, and the solvent was removed by distillation. The resultingresidue was purified by column chromatography (silica gel-chloroform) toobtain a viscous liquid. This was subjected to fractionating thin-layerchromatography (Art 5717 manufactured by Merk Co.; kieserite gel 60F₂₅₄), whereupon the liquid was developed with a developer ofchloroform. Accordingly, 360 g of the compound No. 4 of the inventionwas obtained This was a colorless viscous liquid and had the followingphysical data:

n_(D) ¹⁹ 1.5078.

¹ H-NMR [δ Value (ppm), CDCl₃ ] 1.25(3H, s), 1.50˜2.40 (6H, m), 3/62 (3Hs), 3.84 (6H, s), 5.56(1H, s), 5.55˜5.80(1H, m).

EXAMPLE 5 Preparation of Compound No. 5: ##STR9##

In the same manner as in Example 2 except that 0.85 g (5 mmol) of ethyl2-oxocyclohexanecarboxylate was used, 0.5 g of the above-entitledcompound was obtained as a pale yellow liquid. This had the followingphysical data:

n_(D) ²³.5 1.5126.

¹ H-NMR [δ Value (ppm) CDCl₃ ] 1.04(t,3H, J=7 Hz), 1.60˜2.05 (m, 4H),2.20˜2.65 (m,4H), 3.85(s,6H), 3.97(q, 2H, J=7 Hz), 5.62(s, 1H).

EXAMPLE 6 Preparation of Cis/Trans Mixture: ##STR10##

3.2 g of borane/tert-butylamine complex was added to 200 ml of diethylether solution containing 15.6 g (0.10 mol) of methylcyclohexanone-2-carboxylate and stirred overnight at room temperature.An aqueous diluted hydrochloric acid was added thereto to make it weaklyacidic, which was then subjected to liquid-liquid separation. Theorganic layer separated was dried, concentrated and then distilled underreduced pressure to obtain 13.4 g of ethyl2-hydroxycyclohexanecarboxylate. Yield: 84.8%. b.p. 60° to 62° C. (0.3mmHg).

1.58 g (10 mmol) of the methyl 2-hydroxycyclohexanecarboxylate and 2.0 g(9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolvedin 50 ml of absolute tetrahydrofuran and then cooled with ice. Next, 0.5g of 55% oily sodium hydride was added thereto and stirred overnight.The finish of the reaction was confirmed by high-performance liquidchromatography, and the reaction mixture was poured into ice-water. Thiswas then extracted with ethyl acetate and dried over anhydrous sodiumsulfate, and the solvent was removed by distillation. The residue waspurified by column chromatography to obtain 2.6 g of the above-entitledcompound of the invention as a colorless viscous liquid. Yield: 87.6%.This had the following physical data:

¹ H-NMR [δ Value (ppm), CDCl₃ ] 1.10˜2.90 (9H, m), 3.53 (3H, s),3.82(6H, s), 5.05˜5.45 (0.4H, m), 5.52(0.6H, bs), 5.56(1H, s).

EXAMPLE 7 Preparation of Compound No. 6 (Cis/Trans Mixture): ##STR11##

3.2 g of borane/tert-butylamine complex was added to 200 ml of diethylether solution containing 17.0 g (0.10 mol) of ethylcyclohexanone-2-carboxylate and stirred overnight at room temperature.An aqueous diluted hydrochloric acid was added thereto to make it weaklyacidic, which was then subjected to liquid-liquid separation. Theorganic layer thus separated was dried, concentrated and then distilledunder reduced pressure to obtain 13.5 g of ethyl2-hydroxycyclohexanecarboxylate. Yield: 78.5%. b.p. 68° to 71° C. (0.2mmHg).

1.72 g (10 mmol) of the ethyl 2-hydroxycyclohexanecarboxylate and 2.0 g(9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolvedin 50 ml of absolute tetrahydrofuran and then cooled with ice. Next, 0.5g of 55% oily sodium hydride was added thereto and stirred overnight.The finish of the reaction was confirmed by high-performance liquidchromatography, and the reaction mixture was poured into ice-water. Thiswas then extracted with ethyl acetate, and dried over anhydrous sodiumsulfate, and the solvent was removed by distillation. The residue waspurified by column chromatography to obtain 2.6 g of the compound No. 6of the invention as a colorless viscous liquid Yield: 83.9%

EXAMPLE 8 Preparation of Compound No. 7 (Cis-Form): ##STR12## 0.80 g (5mmol) of methyl cis-2-hydroxycyclohexanecarboxylate and sodium hydride(5 mmol) were dissolved in 20 ml of dimethylformamide and stirred for 30minutes with cooling with ice.

Next, 1.1 g of 2-methylsulfonyl-4,6-dimethoxy-pyrimidine was addedthereto and stirred for 2 hours at 40° to 50° C. After cooled, thesovlent was removed by distillation under reduced pressure. Water wasadded to the residue, which was then extracted with ethyl acetate.

The ethyl acetate extract was washed with water and dried, and thesolvent was removed by distillation under reduced pressure. Accordingly,a pale yellow oily product was obtained. This was purified by silica gelcolumn chromatography to obtain 1.1 g of the compound No. 7 of theinvention as a colorless viscous liquid. This had the following physicaldata:

n_(D) ²⁰ 1.5104.

¹ H-NMR [δ Value (ppm), CDCl₃ ] 1.20˜3.00 (m,9H), 3.53(s, 3H), 3.82(s,6H), 5.52(bs, 1H), 5.54 (s,1H).

EXAMPLE 9 Isolation of Compound No. 9 (Trans-Form): ##STR13##

1.0 g of the compound No. 8 of the invention as prepared in Example 6was subjected to fractionating thin-layer chromatography (Art 5717manufactured by Merk Co.; kieserite gel 60 F₂₅₄) and developed with adeveloper of chloroform/ethyl acetate (10/1), whereupon a fractionhaving a higher Rf value was fractionated from the two components.Accordingly, 300 mg of the compound No. 9 of the invention was obtained.This was a colorless viscous liquid and had the following physical data:

n_(D) ¹⁹.5 1.5060.

¹ H-NMR [δ Value (ppm), CDCl₃ ] 1.10˜3.00(9H, m), 3.55(3H, s), 3.87 (6H,s), 5.00˜5.45(1H, m), 5.59(1H, s).

EXAMPLE 10 Isolation of Compound No. 8 (Cis-Form): ##STR14##

In accordance with the same process as in Example 9, a fraction having alower Rf value was isolated and 550 g of the compound No. 8 of theinvention was obtained from Compound No. 6. This was a colorless viscousliquid and had the following physical data.

n_(D) ¹⁹.0 1.5052.

¹ H-NMR [δValue(ppm), CDCl₃ ] 1.09 (3H, t, J=6.5 Hz), 1.10˜2.85 (9H, m),3.83 (6H, s), 4.00 (2H, q, J=6.5 Hz), 5.56 (1H, s), 5.57 (1H,bs).

EXAMPLE 11 Isolation of Compound No. 10 (Trans-Form): ##STR15##

1.0 g of the compound No. 6 of the invention as prepared in Example 7was fractionated in the same manner as in Example 9, and a fractionhaving a higher Rf value was isolated. Accordingly, 450 mg of thecompound No. 10 of the invention was obtained. This was a colorlessviscous liquid and had the following physical data:

n_(D) ¹⁹.0 1.5035.

¹ H-NMR [δValue (ppm), CDCl₃ ] 1.11 (3H, t, J=6.5 Hz), 1.10˜2.95 (9H,m), 3.84 (6H, s), 3.99 (2H, q, J=6.5 Hz), 4.98˜5.57 (1H, m), 5.58 (1H,s).

EXAMPLE 12 Isolation of Compound No. 11 (Cis(+)-Form) and Compound No.12 (Cis(-)-Form): ##STR16##

600 mg of the cis-form obtained in Example 8 was subjected tohigh-performance liquid chromatography (n-hexane/isopropyl alcohol of50/1, liquid flow rate of 3 ml/min), using an optical active column(Chiral Cell OC, manufactured by Daisel Co.; 25×1 cm) for opticalseparation.

Accordingly, 300 mg of the first eluate of the cis(-)-form of thecompound No. 12 of the invention and 270 mg of the last eluate of thecis(+)-form of the compound No. 11 of the invention were separatelyobtained.

The cis(-)-form of the compound 12 had the following physical data:

Specific Rotatory Power: [α]_(D) ²³.3 -7.72 (c=1.165, CHCl₃).

The cis(+)-form of the compound 11 had the following physical data:

Specific Rotatory Power: [α]_(D) ²³.3 +8.34 (c=1.030, CHCl₃).

EXAMPLE 13 Isolation of Compound No. 13 (Trans(+)-Form) and Compound No.14 (Trans(-)-Form): ##STR17##

1.0 g of the trans-form obtained in Example 11 was subjected tohigh-performance liquid chromatography (n-hexane/isopropyl alcohol of100/1, liquid flow rate of 3 ml/min), using an optical active column(Chiral Cell OC, manufactured by Daisel Co.; 25×1 cm) for opticalseparation.

Accordingly, 230 mg of the first eluate of the trans(-)-form of thecompound No. 14 of the invention and 270 mg of the last eluate of thetrans(+)-form of the compound No. 13 of the invention were separatelyobtained.

The trans(-)-form of the compound No. 14 had the following physicaldata:

Specific Rotatory Power: [α]_(D) ²³.4 -22.91 (c=1.008, CHCl₃).

The trans(+)-form of the compound No. 13 had the following physicaldata:

Specific Rotatory Power: [α]_(D) ²³.4 +17.94 (c=1.287, CHCl₃).

EXAMPLE 14 Production of Compound No. 15: ##STR18##

1.6 g (9.3 mmol) of methyl 2-mercaptocyclohexenecarboxylate and 2.0 g(9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolvedin 50 ml of absolute tetrahydrofuran, and 0.5 g of 50% oily sodiumhydride was added thereto and stirred overnight. The end point of thereaction was confirmed by high-performance liquid chromatography, andthe reaction mixture was poured into ice-water. This was extracted withethyl acetate, and the organic layer was dried over anhydrous sodiumsulfate. The solvent was removed by distillaiton, and the resultingresidue was purified by column chromatography (silica gel-chloroform) toobtain 2.3 g of a colorless viscous liquid. Yield: 81.6%. This wasdeveloped by fractionating thin-layer chromatography (Art 5717manufactured by Merk, kieserite gel 60 F₂₅₄), using a developer ofchloroform/ethyl acetate (19/1). By fractionating purification, 1.8 g ofthe compound No. 15 of the invention was obtained. This had thefollowing physical data:

¹ H-NMR [δValue (ppm), CDCl₃ ] 1.05˜2.36 (8H, m), 3.81 (6H, s), 3.86(3H, s), 5.78 (1H, s).

EXAMPLE 15 Preparation of Compound No. 16: ##STR19##

1.6 g (9.2 mmol) of methyl 2-mercaptocyclohexenecarboxylate and 2.0 g(9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolvedin 50 ml of absolute tetrahydrofuran, and 0.5 g of 50% oily sodiumhydride was added thereto and stirred overnight. The end point of thereaction was confirmed by high-performance liquid chromatography, andthe reaction mixture was poured into ice-water. This was extracted withethyl acetate, and the organic layer was dried over anhydrous sodiumsulfate. The solvent was removed by distillation, and the resultingresidue was purified by column chromatography (silica gel-chloroform) toobtain 2.3 g of a colorless viscous liquid. Yield: 81.6%. This wasdeveloped by fractionating thin layer chromatography (Art 5717,manufactured by Merk Co.; kieserite gel 60 F₂₅₄), using a developer ofchloroform/ethyl acetate (19/1). Accordingly, 0.70 g of the compound No.16 of the invention was obtained. Yield: 24%. This was a pale yellowviscous liquid and had the following physical data:

n_(D) ²¹.5 1.5443.

¹ H-NMR [δValue (ppm), CDCl₃ ] 1.10˜2.40 (8H, m), 2.60˜3.10 (1H, m),3.56 (3H, s), 3.83 (6H, s), 4.22˜4.51 (1H, m), 5.58 (1H, s).

EXAMPLE 16 Preparation of Compound No. 17 (Cis-Form): ##STR20##

1.8 g (10 mmol) of methyl 2-hydroxy-6,6-dimethylcyclohexanecarboxylateand 2.0 g (9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine weredissolved in 50 ml of absolute tetrahydrofuran, and 0.5 g of 50% oilysodium hydride was added thereto and stirred overnight. The end point ofthe reaction was confirmed by high-performance liquid chromatography,and the reaction mixture was poured into ice-water. This was extractedwith ethyl acetate and the organic layer was dried over anhydrous sodiumsulfate. The solvent was removed by distillation and the resultingresidue (comprising two components by analysis of high-performanceliquid chromatography) was purified by high-performance liquidchromatography, whereupon the latter peak was isolated to obtain 0.55 gof the compound No. 17 of the invention. Yield: 17%. This was a whitecrystal and had a melting point of 120.0° to 123.0° C. and the followingphysical data:

¹ H-NMR [δValue (ppm), CDCl₃ ] 0.92 (3H, s), 1.09 )3H, s), 0.90˜2.45(6H, m), 3.00 (1H, d, J=7 Hz), 3.51 (3H, s), 3.83 (6H, s), 5.00˜5.55(1H, m), 5.57 (1H, s).

EXAMPLE 17 Preparation of Compound No. 18 (Trans-Form): ##STR21##

1.8 g (10 mmol) of methyl 2-hydroxy-6,6-dimethylcyclohexanecarboxylateand 2.0 g/(9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine weredissolved in 50 ml of absolute tetrahydrofuran, and 0.5 g of 50% oilysodium hydride was added thereto and stirred overnight. The end point ofthe reaction was confirmed by high-performance liquid chromatography,and the reaction mixture was poured into ice-water. This was extractedwith ethyl acetate, and the organic layer was dried over anhydroussodium sulfate. The solvent was removed by distillation, and theresulting residue (comprising two components by analysis ofhigh-performance liquid chromatography) was purified by high-performanceliquid chromatography, whereupon the former peak was isolated to obtain0.65 g of the compound No. 18 of the invention. Yield: 20%. This was awhite crystal and had a melting point of 82.0° to 84.0° C. and thefollowing physical data:

¹ H-NMR [δValue (ppm), CDCl₃ ] 1.01 (3H, s), 1.06 (3H, s), 1.40˜2.80(6H, m), 2.62 (1H, d, J=11 Hz), 3.58 (3H, s), 3.83 (6H, s), 5.05˜5.80(1H, m), 5.67 (1H, s).

EXAMPLE 18 Preparation of Compound No. 19: ##STR22##

2.4 g (10 mmol) of 2,2-diethoxycarbonylcyclohexyl alcohol and 2.0 g (9.2mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolved in 50ml of absolute tetrahydrofuran, and 0.5 g of 50% oily sodium hydride wasadded thereto and stirred overnight. The end point of the reaction wasconfirmed by high-performance liquid chromatography, and the reactionmixture was poured into ice-water. This was extracted with ethylacetate, and the organic layer was dried over anhydrous sodium sulfate.The solvent was removed by distillation, and the residue was purified byhigh-performance liquid chromatography. Accordingly, 1.6 g of thecompound No. 19 of the invention was obtained as a colorless viscousliquid. Yield: 41%. This had the following physical data:

n_(D) ²⁰ 1.4955.

¹ H-NMR [δValue (ppm), CDCl₃ ] 1.05 (3H, t, J=7 Hz), 1.26 (3H, t, J=7Hz), 1.30˜2.45 (8H, m), 3.85 (6H, s), 4.04 (2H, q, J=7 Hz), 4.18 (2H, q,J=7 Hz), 5.58 (1H, s), 5.74˜5.89 (1H, m).

EXAMPLE 19 Preparation of Compound No. 22: ##STR23##

1.7 g (10 mmol) of methyl 2-oxocycloheptanecarboxylate and 2.0 g (9.2mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolved in 50ml of absolute tetrahydrofuran, and 0.5 g of 50% oily sodium hydride wasadded thereto and stirred overnight. The end point of the reaction wasconfirmed by high-performance liquid chromatography, and the reactionmixture was poured into ice-water. This was extracted with ethyl acetateand the organic layer was dried over anhydrous sodium sulfate. Thesolvent was removed by distillation, and the resulting residue waspurified by column chromatography (silica gel-chloroform) to obtain 1.5g of a viscous liquid. Yield: 48.7%. This had the following physicaldata:

n_(D) ²⁰ 1.5115.

¹ H-NMR [δValue (ppm), CDCl₃ ] 1.20˜3.00 (10H, m), 3.51 (3H, s), 3.71(6H, s), 5.57 (1H, s).

EXAMPLE 20 Preparation of Compound No. 23: ##STR24##

1.7 g (10 mmol) of methyl 2-hydroxycycloheptanecarboxylate and 2.0 g(9.2 mmol) of 2-methanesulfonyl-4,6-dimethoxypyrimidine were dissolvedin 50 ml of absolute tetrahydrofuran, and 0.5 g of 50% oily sodiumhydride was added thereto and stirred overnight. The end point of thereaction was confirmed by high-performance liquid chromatography, andthe reaction mixture was poured into ice-water. This was extracted withethyl acetate, and the organic layer was dried over anhydrous sodiumsulfate. The solvent was removed by distillation, and the resultingresidue was purified by column chromatography (silica gel-chloroform) toobtain 1.2 g of a colorless viscous liquid. Yield: 38.7%. This had thefollowing physical data:

n_(D) ²⁰ 1.5128.

¹ H-NMR [δValue (ppm), CDCl₃ ] 1.30˜2.40 (10H, m), 2.70˜3.20 (1H, m),2.55 (3H, s), 3.84 (6H, s), 5.56 (1H, s), 5.30-5.75 (1H, m).

In the same manner as in anyone of the previously mentioned Examples 1to 20, the compounds of the present invention as shown in Tables 1 to 5below were obtained.

The structural formulae and the physical data of the compounds obtainedin these examples are shown in Table 6 below.

The compound Nos. of the present invention as prepared above arereferred to in Composition Examples and Experiment Examples mentionedbelow.

Where the pyrimidine derivatives or the optical isomers thereof of thepresent invention are employed as a herbicide, they may be combined witha suitable carrier, for example, a solid carrier such as clay, talc,bentonite or diatomaceous earth or a liquid carrier such as water,alcohols (methanol, ethanol), aromatic hydrocarbons (benzene, toluene,xylene), chlorinated hydrocarbons, ethers, ketones, esters (ethylacetate) or acid amides (dimethylformamide). If desired, any otheradditives such as an emulsifier, a dispersing agent, a suspending agent,a wetting agent, a spreader and/or a stabilizer may optionally be addedto the herbicidal composition of the present invention. The compositionmay be in the form of a liquid composition, an emulsion, a wettablepowder, a dust, a granular composition, a flowable agent or othervarious forms for practical use.

The content of the active ingredient of the herbicidal composition isnot specifically limited but, in general, is desired to fall within therange of from 0.10 to 90.0% by weight.

If desired, the herbicidal composition of the present invention mayfurther be combined with any other herbicides, various insecticides,fungicides, plant growth regulators and/or synergistic agents, inpreparing the composition or in spraying the same for actual use.

For instance, the compounds described in Farm Chemicals Handbook, 75thEd. (1989) are referred to.

The pyrimidine derivatives and the optical isomers thereof of thepresent invention can be applied not only to upland, paddy fields orfruit farms but also to non-agricultural areas such as playgrounds,vacant lands or railway track spaces for the purpose of killing variousweeds therein. The amount of the active ingredient to be applied forsuch herbicidal purpose is generally from 0.005 to 10 kg/ha or so,though varying in accordance with the place to which the herbicide isapplied, the time when the herbicide is applied, the method of applyingthe herbicide, the kind of weeds to be killed by the herbicide and thekind of the crops to be protected by application of the herbicide.

Next, some examples of herbicidal compositions containing the pyrimidinederivative or the optical isomer thereof of the present invention as theactive ingredient will be mentioned below, which, however, are notintended to restrict the scope of the present invention.

Unless otherwise specifically limited, all "parts" are by weight.

Liquid Composition:

Active Ingredient: 5 to 75 parts, preferably 10 to 50 parts, especiallypreferably 15 to 40 parts

Liquid Carrier: 95 to 25 parts, preferably 88 to 30 parts, especiallypreferably 82 to 40 parts

Surfactant 1 to 30 parts, preferably 2 to 20 parts

Emulsion:

Active Ingredient: 1 to 50 parts, preferably 5 to 45 parts, especiallypreferably 10 to 40 parts

Surfactant: 1 to 30 parts, preferably 2 to 25 parts, especiallypreferably 3 to 20 parts

Liquid Carrier: 20 to 95 parts, preferably 30 to 93 parts, especiallypreferably 57 to 85 parts

Dust:

Active Ingredient: 0.5 to 10 parts, especielly preferably 15 to 40 parts

Solid Carrier: 95.5 to 90 parts

Flowable Agent:

Active Ingredient: 5 to 75 parts, preferably 10 to 50 parts

Water: 94 to 25 parts, preferably 90 to 30 parts

Surfactant: 1 to 30 parts, preferably 2 to 20 parts

Wettable Powder:

Active Ingredient: 2.5 to 90 parts, preferably 10 to 80 parts,especially preferably 20 to 75 parts

Surfactant: 0.5 to 20 parts, preferably 1 to 15 parts, especiallypreferably 2 to 10 parts

Liquid Carrier: 5 to 90 parts, preferably 7.5 to 88 parts, especiallypreferably 16 to 56 parts

Granular Composition:

Active Ingredient: 0.1 to 30 parts

Solid Carrier: 99.5 to 70 parts

The liquid composition and the emulsion are prepared by dissolving anactive ingredient into a surfactant-containing liquid carrier. Thewettable powder is prepared by blending a surfactant, a solid carrierand an active ingredient and then powdering the resulting blend.

The dust is prepared by blending a surfactant, a solid carrier and anactive ingredient and, if desired, further pulverizing the resultingblend.

The flowable agent is prepared by suspending and dispersing an activeingredient in a surfactant-containing aqueous solution.

The granular composition is prepared by blending an active ingredientand the adjuvant.

COMPOSITION EXAMPLE 1

    ______________________________________                                        Wettable Powder:                                                              ______________________________________                                        Compound No. 9 of the Invention                                                                     50 parts                                                Zeeklite PFP,         43 parts                                                (kaolin clay, trade name of                                                   Zeeklite Industry Co.)                                                        Sorpol 5039            5 parts                                                (mixture of nonionic surfactant                                               and anionic surfactant,                                                       trade name by Toho Chemical Co.)                                              Carplex (anti-caking agent)                                                                          2 parts                                                (mixture of surfactant and                                                    white carbon, trade name                                                      of Shionogi Pharmaceutical Co.)                                               ______________________________________                                    

The above-mentioned ingredients were blended and powdered to obtain awettable powder. For actual use, the powder is diluted with water toform 1/10 to 1/10,000 and is sprayed in an amount of from 0.005 to 10kg/ha as the active ingredient.

COMPOSITION EXAMPLE 2

    ______________________________________                                        Emulsion:                                                                     ______________________________________                                        Compound No. 6 of the Invention                                                                     10 parts                                                Xylene                70 parts                                                Dimethylformamide     10 parts                                                Sorpol 2680           10 parts                                                (mixture of nonionic surfactant                                               and anionic surfactant,                                                       trade name of Toho Chemical Co.)                                              ______________________________________                                    

The above-mentioned ingredients were uniformly blended to form anemulsion. For actual use, this is diluted to from 1/10 to 1/10,000 andis sprayed in an amount of from 0.005 to 10 kg/ha as the activeingredient.

COMPOSITION EXAMPLE 3

    ______________________________________                                        Granular Composition:                                                         ______________________________________                                        Compound No. 13 of the Invention                                                                     5 parts                                                Bentonite             54 parts                                                Talc                  40 parts                                                Calcium ligninesulfonate                                                                             1 part.sup.                                            ______________________________________                                    

The above-mentioned ingredients were uniformly blended and pulverized,and a small amount of water was added thereto, granulated through agranulating extruder and dried to obtain a granular composition. Foractual use, this is applied in an amount of from 0.005 to 10 kg/ha asthe active ingredient.

COMPOSITION EXAMPLE 4

    ______________________________________                                        Flowable Agent:                                                               ______________________________________                                        Compound No. 9 of the Invention                                                                        25     parts                                         Sorpol 3353              10     parts                                         (nonionic surfactant, trade name                                              of Toho Chemical Co.)                                                         Lunox 1000 C             0.5    part                                          (anionic surfactant, trade name                                               of Toho Chemical Co.)                                                         1% Aqueous Xanthan Gum Solution                                                                        20     parts                                         (natural high polymer substance)                                              Water                    44.5   parts                                         ______________________________________                                    

Sorpol 3353, Lunox 100 C and 1% aqueous Xanthan gum solution wereuniformly dissolved in water, and then the compound No. 9 of theinvention was added thereto and well stirred. The resulting blend wasthen wet-powdered with a sand mill to obtain a flowable agent. Forpractical use, this is diluted to from 1/10 to 1/10,000 and dispersed inan amount of from 0.005 to 10 kg/ha as the active ingredient.

Next, the usefulness of the compounds of the present invention as aherbicide will be explained concretely by way of the followingExperiment Examples.

EXPERIMENT EXAMPLE 1 Herbicidal Test in Soil Treatment:

A sterilized farm soil was put in a plastic box having a length of 30cm, a width of 22 cm and a depth of 6 cm, and Echinochoa crus galli,Cyperus microiria, Solanum nigrum, Galinosoga ciliate, Rorippa indicaand cotton were seeded. After the seeds were covered with the soil in adepth of about 1.5 cm the above-mentioned liquid composition, wettablepowder, emulsion and flowable agent were diluted with water, and eachwas sprayed over the complete surface of the soil in the box with asmall-sized spray, in a determined amount as the active ingredient. Fourweeks after the spraying, the herbicidal effect to the weeds was checkedin accordance with the evaluation criterion mentioned below.

Herbicidal Effect Evaluation Criterion:

5: Herbicidal effect was 90 % or more. (Almost all were completelykilled.)

4: Herbicidal effect was 70 to 90%.

3: Herbicidal effect was 40 to 70%.

2: Herbicidal effect was 20 to 40%.

1: Herbicidal effect was 5 to 20%.

0: Herbicidal effect was less than 5%.(Almost ineffective.)

The herbicidal effect in the above-mentioned evaluation was calculatedout from the following equation, on the basis of the weight of theliving plants over the soil to which the herbicide was applied and thatof the living plants over the soil (control) to which no herbicide wasapplied. ##EQU1##

The results obtained are shown in Table 7 below.

EXPERIMENT EXAMPLE 2 Herbicidal Test in Foliage Application:

A sterilized farm soil was put in a plastic box having a length of 30cm, a width of 22 cm and a depth of 6 cm, and Echinochoa crus galli,Cyperus microiria, Solanum nigrum, Galinsoga ciliate, Rorippa indica,and rice, cotton and beet were spot-like seeded and were covered with asoil in a depth of about 1.5 cm. After the plant seedlings became two-to three-leaves stage, the above-mentioned liquid composition, wettablepowder, emulsion or flowable agent as diluted with water was sprayedover the complete surfaces of the leaves of the weeds and the crops witha small-sized spray, in a determined amount as the active ingredient.Four weeks after the spraying, the herbicidal effect to the weeds waschecked in accordance with the same evalaution criterion as inExperiment Example 1. The results obtained are shown in Table 8 below.

                  TABLE 1                                                         ______________________________________                                        A compound of the general formula:                                             ##STR25##                                                                    In the below-mentioned table, Me represents methyl group, Et                  represents ethyl group, Pr represents propyl group, .sup.i Pr represents      isopropyl group, Bu represents butyl group, .sup.i Bu represents              isobutyl group, .sup.s Bu represents butyl secondary butyl group, .sup.t      Bu                                                                            represents tertiary butyl group, cis represents a cis-form, trans             represents a trans-form, mix. represents a mixture of a cis-form              and a trans-form, 1 represents a single bond and 2 represents                 a double bond.                                                                (X).sub.m       R              R.sup.1                                                                              R.sup.2                                 ______________________________________                                        --     1 (cis)  H              Me     Me                                      --     1 (cis)  Li             Me     Me                                      --     1 (cis)  Na             Me     Me                                      --     1 (cis)  K              Me     Me                                      --     1 (cis)  1/2Mg          Me     Me                                      --     1 (cis)  1/2Ca          Me     Me                                      --     1 (cis)  MeNH.sub.3     Me     Me                                      --     1 (cis)  EtNH.sub.3     Me     Me                                      --     1 (cis)  PrNH.sub.3     Me     Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     1 (cis)  Me             Me     Me                                      --     1 (cis)  Et             Me     Me                                      --     1 (cis)  .sup.i Pr      Me     Me                                      --     1 (cis)  Pr             Me     Me                                      --     1 (cis)  Bu             Me     Me                                      --     1 (cis)  .sup.i Bu      Me     Me                                      --     1 (cis)  .sup.s Bu      Me     Me                                      --     1 (cis)  .sup.t Bu      Me     Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C CH.sub.2                                                                          Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     1 (cis)  H              OMe    Me                                      --     1 (cis)  Li             OMe    Me                                      --     1 (cis)  Na             OMe    Me                                      --     1 (cis)  K              OMe    Me                                      --     1 (cis)  1/2Mg          OMe    Me                                      --     1 (cis)  1/2Ca          OMe    Me                                      --     1 (cis)  MeNH.sub.3     OMe    Me                                      --     1 (cis)  EtNH.sub.3     OMe    Me                                      --     1 (cis)  PrNH.sub.3     OMe    Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     1 (cis)  Me             OMe    Me                                      --     1 (cis)  Et             OMe    Me                                      --     1 (cis)  .sup.i Pr      OMe    Me                                      --     1 (cis)  Pr             OMe    Me                                      --     1 (cis)  Bu             OMe    Me                                      --     1 (cis)  .sup.i Bu      OMe    Me                                      --     1 (cis)  .sup.s Bu      OMe    Me                                      --     1 (cis)  .sup.t Bu      OMe    Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     1 (cis)  H              OMe    OMe                                     --     1 (cis)  Li             OMe    OMe                                     --     1 (cis)  Na             OMe    OMe                                     --     1 (cis)  K              OMe    OMe                                     --     1 (cis)  1/2Mg          OMe    OMe                                     --     1 (cis)  1/2Ca          OMe    OMe                                     --     1 (cis)  MeNH.sub. 3    OMe    OMe                                     --     1 (cis)  EtNH.sub.3     OMe    OMe                                     --     1 (cis)  PrNH.sub.3     OMe    OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     --     1 (cis)  Me             OMe    OMe                                     --     1 (cis)  Et             OMe    OMe                                     --     1 (cis)  .sup.i Pr      OMe    OMe                                     --     1 (cis)  Pr             OMe    OMe                                     --     1 (cis)  Bu             OMe    OMe                                     --     1 (cis)  .sup.i Bu      OMe    OMe                                     --     1 (cis)  .sup.s Bu      OMe    OMe                                     --     1 (cis)  .sup.t Bu      OMe    OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     1 (cis)  H              Cl     Me                                      --     1 (cis)  Li             Cl     Me                                      --     1 (cis)  Na             Cl     Me                                      --     1 (cis)  K              Cl     Me                                      --     1 (cis)  1/2Mg          Cl     Me                                      --     1 (cis)  1/2Ca          Cl     Me                                      --     1 (cis)  MeNH.sub.3     Cl     Me                                      --     1 (cis)  EtNH.sub.3     Cl     Me                                      --     1 (cis)  PrNH.sub.3     Cl     Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Cl     Me                                      --     1 (cis)  Me             Cl     Me                                      --     1 (cis)  Et             Cl     Me                                      --     1 (cis)  .sup.i Pr      Cl     Me                                      --     1 (cis)  Pr             Cl     Me                                      --     1 (cis)  Bu             Cl     Me                                      --     1 (cis)  .sup.i Bu      Cl     Me                                      --     1 (cis)  .sup.s Bu      Cl     Me                                      --     1 (cis)  .sup.t Bu      Cl     Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Cl     Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Me                                      --     1 (cis)  H              Cl     Cl                                      --     1 (cis)  Li             Cl     Cl                                      --     1 (cis)  Na             Cl     Cl                                      --     1 (cis)  K              Cl     Cl                                      --     1 (cis)  1/2Mg          Cl     Cl                                      --     1 (cis)  1/2Ca          Cl     Cl                                      --     1 (cis)  MeNH.sub.3     Cl     Cl                                      --     1 (cis)  EtNH.sub.3     Cl     Cl                                      --     1 (cis)  PrNH.sub.3     Cl     Cl                                      --     1 (cis)  .sup. i PrNH.sub.3                                                                           Cl     Cl                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     1 (cis)  Me             Cl     Cl                                      --     1 (cis)  Et             Cl     Cl                                      --     1 (cis)  .sup.i Pr      Cl     Cl                                      --     1 (cis)  Pr             Cl     Cl                                      --     1 (cis)  Bu             Cl     Cl                                      --     1 (cis)  .sup.i Bu      Cl     Cl                                      --     1 (cis)  .sup.s Bu      Cl     Cl                                      --     1 (cis)  .sup.t Bu      Cl     Cl                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Cl     Cl                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Cl                                      --     1 (cis)  H              Cl     OMe                                     --     1 (cis)  Li             Cl     OMe                                     --     1 (cis)  Na             Cl     OMe                                     --     1 (cis)  K              Cl     OMe                                     --     1 (cis)  1/2Mg          Cl     OMe                                     --     1 (cis)  1/2Ca          Cl     OMe                                     --     1 (cis)  MeNH.sub.3     Cl     OMe                                     --     1 (cis)  EtNH.sub.3     Cl     OMe                                     --     1 (cis)  PrNH.sub.3     Cl     OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     1 (cis)  NH.sub.2 CONH.sub. 3                                                                         Cl     OMe                                     --     1 (cis)  Me             Cl     OMe                                     --     1 (cis)  Et             Cl     OMe                                     --     1 (cis)  .sup.i Pr      Cl     OMe                                     --     1 (cis)  Pr             Cl     OMe                                     --     1 (cis)  Bu             Cl     OMe                                     --     1 (cis)  .sup.i Bu      Cl     OMe                                     --     1 (cis)  .sup.s Bu      Cl     OMe                                     --     1 (cis)  .sup.t Bu      Cl     OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub. 4Cl-4                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     1 (cis)  H              Cl     OMe                                     --     1 (cis)  Li             Cl     OMe                                     --     1 (cis)  Na             Cl     OMe                                     --     1 (cis)  K              Cl     OMe                                     --     1 (cis)  1/2Mg          Cl     OMe                                     --     1 (cis)  1/2Ca          Cl     OMe                                     --     1 (cis)  MeNH.sub.3     Cl     OMe                                     --     1 (cis)  EtNH.sub.3     Cl     OMe                                     --     1 (cis)  PrNH.sub.3     Cl     OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     1 (cis)  Me             Cl     OMe                                     --     1 (cis)  Et             Cl     OMe                                     --     1 (cis)  .sup.i Pr      Cl     OMe                                     --     1 (cis)  Pr             Cl     OMe                                     --     1 (cis)  Bu             Cl     OMe                                     --     1 (cis)  .sup.i Bu      Cl     OMe                                     --     1 (cis)  .sup.s Bu      Cl     OMe                                     --     1 (cis)  .sup.t Bu      Cl     OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub. 6 H.sub.4Me-2                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     1 (cis)  H              OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Li             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Na             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  K              OCHF.sub.2                                                                           OMe                                     --     1 (cis)  1/2Mg          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  1/2Ca          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Me             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Et             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Pr             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Bu             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.i Bu      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub. 2 C.sub.6 H.sub.4Cl-4                                                                OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     1 (cis)  H              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  K              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub. 2                             --     1 (cis)  .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  H              SMe    OMe                                     --     1 (cis)  Li             SMe    OMe                                     --     1 (cis)  Na             SMe    OMe                                     --     1 (cis)  K              SMe    OMe                                     --     1 (cis)  1/2Mg          SMe    OMe                                     --     1 (cis)  1/2Ca          SMe    OMe                                     --     1 (cis)  MeNH.sub.3     SMe    OMe                                     --     1 (cis)  EtNH.sub.3     SMe    OMe                                     --     1 (cis)  PrNH.sub.3     SMe    OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     1 (cis)  Me             SMe    OMe                                     --     1 (cis)  Et             SMe    OMe                                     --     1 (cis)  .sup.i Pr      SMe    OMe                                     --     1 (cis)  Pr             SMe    OMe                                     --     1 (cis)  Bu             SMe    OMe                                     --     1 (cis)  .sup.i Bu      SMe    OMe                                     --     1 (cis)  .sup.s Bu      SMe    OMe                                     --     1 (cis)  .sup.t Bu      SMe    OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C CH.sub.2                                                                          SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    OMe                                     --     1 (cis)  H              SMe    Me                                      --     1 (cis)  Li             SMe    Me                                      --     1 (cis)  Na             SMe    Me                                      --     1 (cis)  K              SMe    Me                                      --     1 (cis)  1/2Mg          SMe    Me                                      --     1 (cis)  1/2Ca          SMe    Me                                      --     1 (cis)  MeNH.sub.3     SMe    Me                                      --     1 (cis)  EtNH.sub.3     SMe    Me                                      --     1 (cis)  PrNH.sub.3     SMe    Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     1 (cis)  Me             SMe    Me                                      --     1 (cis)  Et             SMe    Me                                      --     1 (cis)  .sup.i Pr      SMe    Me                                      --     1 (cis)  Pr             SMe    Me                                      --     1 (cis)  Bu             SMe    Me                                      --     1 (cis)  .sup.i Bu      SMe    Me                                      --     1 (cis)  .sup.s Bu      SMe    Me                                      --     1 (cis)  .sup.t Bu      SMe    Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      --     1 (trans)                                                                              H              Me     Me                                      --     1 (trans)                                                                              Li             Me     Me                                      --     1 (trans)                                                                              Na             Me     Me                                      --     1 (trans)                                                                              K              Me     Me                                      --     1 (trans)                                                                              1/2Mg          Me     Me                                      --     1 (trans)                                                                              1/2Ca          Me     Me                                      --     1 (trans)                                                                              MeNH.sub. 3    Me     Me                                      --     1 (trans)                                                                              EtNH.sub.3     Me     Me                                      --     1 (trans)                                                                              PrNH.sub.3     Me     Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     1 (trans)                                                                              Me             Me     Me                                      --     1 (trans)                                                                              Et             Me     Me                                      --     1 (trans)                                                                              .sup.i Pr      Me     Me                                      --     1 (trans)                                                                              Pr             Me     Me                                      --     1 (trans)                                                                              Bu             Me     Me                                      --     1 (trans)                                                                              .sup.i Bu      Me     Me                                      --     1 (trans)                                                                              .sup.s Bu      Me     Me                                      --     1 (trans)                                                                              .sup.t Bu      Me     Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     1 (trans)                                                                              H              OMe    Me                                      --     1 (trans)                                                                              Li             OMe    Me                                      --     1 (trans)                                                                              Na             OMe    Me                                      --     1 (trans)                                                                              K              OMe    Me                                      --     1 (trans)                                                                              1/2Mg          OMe    Me                                      --     1 (trans)                                                                              1/2Ca          OMe    Me                                      --     1 (trans)                                                                              MeNH.sub.3     OMe    Me                                      --     1 (trans)                                                                              EtNH.sub.3     OMe    Me                                      --     1 (trans)                                                                              PrNH.sub.3     OMe    Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     1 (trans)                                                                              Me             OMe    Me                                      --     1 (trans)                                                                              Et             OMe    Me                                      --     1 (trans)                                                                              .sup.i Pr      OMe    Me                                      --     1 (trans)                                                                              Pr             OMe    Me                                      --     1 (trans)                                                                              Bu             OMe    Me                                      --     1 (trans)                                                                              .sup.i Bu      OMe    Me                                      --     1 (trans)                                                                              .sup.s Bu      OMe    Me                                      --     1 (trans)                                                                              .sup.t Bu      OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     1 (trans)                                                                              H              OMe    OMe                                     --     1 (trans)                                                                              Li             OMe    OMe                                     --     1 (trans)                                                                              Na             OMe    OMe                                     --     1 (trans)                                                                              K              OMe    OMe                                     --     1 (trans)                                                                              1/2Mg          OMe    OMe                                     --     1 (trans)                                                                              1/2Ca          OMe    OMe                                     --     1 (trans)                                                                              MeNH.sub.3     OMe    OMe                                     --     1 (trans)                                                                              EtNH.sub.3     OMe    OMe                                     --     1 (trans)                                                                              PrNH.sub.3     OMe    OMe                                     --     1 (trans)                                                                              .sup. i PrNH.sub.3                                                                           OMe    OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     --     1 (trans)                                                                              Me             OMe    OMe                                     --     1 (trans)                                                                              Et             OMe    OMe                                     --     1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     --     1 (trans)                                                                              Pr             OMe    OMe                                     --     1 (trans)                                                                              Bu             OMe    OMe                                     --     1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     --     1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     --     1 (trans)                                                                              .sup.t Bu      OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     1 (trans)                                                                              H              Cl     Me                                      --     1 (trans)                                                                              Li             Cl     Me                                      --     1 (trans)                                                                              Na             Cl     Me                                      --     1 (trans)                                                                              K              Cl     Me                                      --     1 (trans)                                                                              1/2Mg          Cl     Me                                      --     1 (trans)                                                                              1/2Ca          Cl     Me                                      --     1 (trans)                                                                              MeNH.sub.3     Cl     Me                                      --     1 (trans)                                                                              EtNH.sub.3     Cl     Me                                      --     1 (trans)                                                                              PrNH.sub.3     Cl     Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub. 3                                                                         Cl     Me                                      --     1 (trans)                                                                              Me             Cl     Me                                      --     1 (trans)                                                                              Et             Cl     Me                                      --     1 (trans)                                                                              .sup.i Pr      Cl     Me                                      --     1 (trans)                                                                              Pr             Cl     Me                                      --     1 (trans)                                                                              Bu             Cl     Me                                      --     1 (trans)                                                                              .sup.i Bu      Cl     Me                                      --     1 (trans)                                                                              .sup.s Bu      Cl     Me                                      --     1 (trans)                                                                              .sup.t Bu      Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Cl     Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub. 4Cl-4                                                                Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Me                                      --     1 (trans)                                                                              H              Cl     Cl                                      --     1 (trans)                                                                              Li             Cl     Cl                                      --     1 (trans)                                                                              Na             Cl     Cl                                      --     1 (trans)                                                                              K              Cl     Cl                                      --     1 (trans)                                                                              1/2Mg          Cl     Cl                                      --     1 (trans)                                                                              1/2Ca          Cl     Cl                                      --     1 (trans)                                                                              MeNH.sub.3     Cl     Cl                                      --     1 (trans)                                                                              EtNH.sub.3     Cl     Cl                                      --     1 (trans)                                                                              PrNH.sub.3     Cl     Cl                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Cl     Cl                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     1 (trans)                                                                              Me             Cl     Cl                                      --     1 (trans)                                                                              Et             Cl     Cl                                      --     1 (trans)                                                                              .sup.i Pr      Cl     Cl                                      --     1 (trans)                                                                              Pr             Cl     Cl                                      --     1 (trans)                                                                              Bu             Cl     Cl                                      --     1 (trans)                                                                              .sup.i Bu      Cl     Cl                                      --     1 (trans)                                                                              .sup.s Bu      Cl     Cl                                      --     1 (trans)                                                                              .sup.t Bu      Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub. 6 H.sub.4Me-2                                                                Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Cl                                      --     1 (trans)                                                                              H              Cl     OMe                                     --     1 (trans)                                                                              Li             Cl     OMe                                     --     1 (trans)                                                                              Na             Cl     OMe                                     --     1 (trans)                                                                              K              Cl     OMe                                     --     1 (trans)                                                                              1/2Mg          Cl     OMe                                     --     1 (trans)                                                                              1/2Ca          Cl     OMe                                     --     1 (trans)                                                                              MeNH.sub.3     Cl     OMe                                     --     1 (trans)                                                                              EtNH.sub.3     Cl     OMe                                     --     1 (trans)                                                                              PrNH.sub.3     Cl     OMe                                     --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     1 (trans)                                                                              Me             Cl     OMe                                     --     1 (trans)                                                                              Et             Cl     OMe                                     --     1 (trans)                                                                              .sup.i Pr      Cl     OMe                                     --     1 (trans)                                                                              Pr             Cl     OMe                                     --     1 (trans)                                                                              Bu             Cl     OMe                                     --     1 (trans)                                                                              .sup.i Bu      Cl     OMe                                     --     1 (trans)                                                                              .sup.s Bu      Cl     OMe                                     --     1 (trans)                                                                              .sup.t Bu      Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub. 2 C.sub.6 H.sub.4Me-3                                                                Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     1 (trans)                                                                              H              OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Li             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Na             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              K              OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              1/2Mg          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              1/2Ca          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Me             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Et             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Pr             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Bu             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.i Bu      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              H              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              K              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OCHF.sub. 2                             --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              H              SMe    OMe                                     --     1 (trans)                                                                              Li             SMe    OMe                                     --     1 (trans)                                                                              Na             SMe    OMe                                     --     1 (trans)                                                                              K              SMe    OMe                                     --     1 (trans)                                                                              1/2Mg          SMe    OMe                                     --     1 (trans)                                                                              1/2Ca          SMe    OMe                                     --     1 (trans)                                                                              MeNH.sub.3     SMe    OMe                                     --     1 (trans)                                                                              EtNH.sub.3     SMe    OMe                                     --     1 (trans)                                                                              PrNH.sub.3     SMe    OMe                                     --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     1 (trans)                                                                              Me             SMe    OMe                                     --     1 (trans)                                                                              Et             SMe    OMe                                     --     1 (trans)                                                                              .sup.i Pr      SMe    OMe                                     --     1 (trans)                                                                              Pr             SMe    OMe                                     --     1 (trans)                                                                              Bu             SMe    OMe                                     --     1 (trans)                                                                              .sup.i Bu      SMe    OMe                                     --     1 (trans)                                                                              .sup.s Bu      SMe    OMe                                     --     1 (trans)                                                                              .sup.t Bu      SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    OMe                                     --     1 (trans)                                                                              H              SMe    Me                                      --     1 (trans)                                                                              Li             SMe    Me                                      --     1 (trans)                                                                              Na             SMe    Me                                      --     1 (trans)                                                                              K              SMe    Me                                      --     1 (trans)                                                                              1/2Mg          SMe    Me                                      --     1 (trans)                                                                              1/2Ca          SMe    Me                                      --     1 (trans)                                                                              MeNH.sub. 3    SMe    Me                                      --     1 (trans)                                                                              EtNH.sub.3     SMe    Me                                      --     1 (trans)                                                                              PrNH.sub.3     SMe    Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     1 (trans)                                                                              Me             SMe    Me                                      --     1 (trans)                                                                              Et             SMe    Me                                      --     1 (trans)                                                                              .sup.i Pr      SMe    Me                                      --     1 (trans)                                                                              Pr             SMe    Me                                      --     1 (trans)                                                                              Bu             SMe    Me                                      --     1 (trans)                                                                              .sup.i Bu      SMe    Me                                      --     1 (trans)                                                                              .sup.s Bu      SMe    Me                                      --     1 (trans)                                                                              .sup.t Bu      SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      --     1 (mix.) H              Me     Me                                      --     1 (mix.) Li             Me     Me                                      --     1 (mix.) Na             Me     Me                                      --     1 (mix.) K              Me     Me                                      --     1 (mix.) 1/2Mg          Me     Me                                      --     1 (mix.) 1/2Ca          Me     Me                                      --     1 (mix.) MeNH.sub.3     Me     Me                                      --     1 (mix.) EtNH.sub.3     Me     Me                                      --     1 (mix.) PrNH.sub.3     Me     Me                                      --     1 (mix.) .sup.i PrNH.sub.3                                                                            Me     Me                                      --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     1 (mix.) Me             Me     Me                                      --     1 (mix.) Et             Me     Me                                      --     1 (mix.) .sup.i Pr      Me     Me                                      --     1 (mix.) Pr             Me     Me                                      --     1 (mix.) Bu             Me     Me                                      --     1 (mix.) .sup.i Bu      Me     Me                                      --     1 (mix.) .sup.s Bu      Me     Me                                      --     1 (mix.) .sup.t Bu      Me     Me                                      --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     1 (mix.) H              OMe    Me                                      --     1 (mix.) Li             OMe    Me                                      --     1 (mix.) Na             OMe    Me                                      --     1 (mix.) K              OMe    Me                                      --     1 (mix.) 1/2Mg          OMe    Me                                      --     1 (mix.) 1/2Ca          OMe    Me                                      --     1 (mix.) MeNH.sub.3     OMe    Me                                      --     1 (mix.) EtNH.sub.3     OMe    Me                                      --     1 (mix.) PrNH.sub.3     OMe    Me                                      --     1 (mix.) .sup. i PrNH.sub.3                                                                           OMe    Me                                      --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     1 (mix.) Me             OMe    Me                                      --     1 (mix.) Et             OMe    Me                                      --     1 (mix.) .sup.i Pr      OMe    Me                                      --     1 (mix.) Pr             OMe    Me                                      --     1 (mix.) Bu             OMe    Me                                      --     1 (mix.) .sup.i Bu      OMe    Me                                      --     1 (mix.) .sup.s Bu      OMe    Me                                      --     1 (mix.) .sup.t Bu      OMe    Me                                      --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    Me                                      --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     1 (mix.) H              OMe    OMe                                     --     1 (mix.) Li             OMe    OMe                                     --     1 (mix.) Na             OMe    OMe                                     --     1 (mix.) K              OMe    OMe                                     --     1 (mix.) 1/2Mg          OMe    OMe                                     --     1 (mix.) 1/2Ca          OMe    OMe                                     --     1 (mix.) MeNH.sub.3     OMe    OMe                                     --     1 (mix.) EtNH.sub.3     OMe    OMe                                     --     1 (mix.) PrNH.sub.3     OMe    OMe                                     --     1 (mix.) .sup.i PrNH.sub.3                                                                            OMe    OMe                                     --     1 (mix.) NH.sub.2 CONH.sub. 3                                                                         OMe    OMe                                     --     1 (mix.) Me             OMe    OMe                                     --     1 (mix.) Et             OMe    OMe                                     --     1 (mix.) .sup.i Pr      OMe    OMe                                     --     1 (mix.) Pr             OMe    OMe                                     --     1 (mix.) Bu             OMe    OMe                                     --     1 (mix.) .sup.i Bu      OMe    OMe                                     --     1 (mix.) .sup.s Bu      OMe    OMe                                     --     1 (mix.) .sup.t Bu      OMe    OMe                                     --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub. 4Cl-4                                                                OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     1 (mix.) H              Cl     Me                                      --     1 (mix.) Li             Cl     Me                                      --     1 (mix.) Na             Cl     Me                                      --     1 (mix.) K              Cl     Me                                      --     1 (mix.) 1/2Mg          Cl     Me                                      --     1 (mix.) 1/2Ca          Cl     Me                                      --     1 (mix.) MeNH.sub.3     Cl     Me                                      --     1 (mix.) EtNH.sub.3     Cl     Me                                      --     1 (mix.) PrNH.sub.3     Cl     Me                                      --     1 (mix.) .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          Cl     Me                                      --     1 (mix.) Me             Cl     Me                                      --     1 (mix.) Et             Cl     Me                                      --     1 (mix.) .sup.i Pr      Cl     Me                                      --     1 (mix.) Pr             Cl     Me                                      --     1 (mix.) Bu             Cl     Me                                      --     1 (mix.) .sup.i Bu      Cl     Me                                      --     1 (mix.) .sup.s Bu      Cl     Me                                      --     1 (mix.) .sup.t Bu      Cl     Me                                      --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Cl     Me                                      --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub. 6 H.sub.4Me-2                                                                Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Me                                      --     1 (mix.) H              Cl     Cl                                      --     1 (mix.) Li             Cl     Cl                                      --     1 (mix.) Na             Cl     Cl                                      --     1 (mix.) K              Cl     Cl                                      --     1 (mix.) 1/2Mg          Cl     Cl                                      --     1 (mix.) 1/2Ca          Cl     Cl                                      --     1 (mix.) MeNH.sub.3     Cl     Cl                                      --     1 (mix.) EtNH.sub.3     Cl     Cl                                      --     1 (mix.) PrNH.sub.3     Cl     Cl                                      --     1 (mix.) .sup.i PrNH.sub.3                                                                            Cl     Cl                                      --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     1 (mix.) Me             Cl     Cl                                      --     1 (mix.) Et             Cl     Cl                                      --     1 (mix.) .sup.i Pr      Cl     Cl                                      --     1 (mix.) Pr             Cl     Cl                                      --     1 (mix.) Bu             Cl     Cl                                      --     1 (mix.) .sup.i Bu      Cl     Cl                                      --     1 (mix.) .sup.s Bu      Cl     Cl                                      --     1 (mix.) .sup.t Bu      Cl     Cl                                      --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           Cl     Cl                                      --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Cl                                      --     1 (mix.) CH.sub. 2 C.sub.6 H.sub.4Me-3                                                                Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Cl                                      --     1 (mix.) H              Cl     OMe                                     --     1 (mix.) Li             Cl     OMe                                     --     1 (mix.) Na             Cl     OMe                                     --     1 (mix.) K              Cl     OMe                                     --     1 (mix.) 1/2Mg          Cl     OMe                                     --     1 (mix.) 1/2Ca          Cl     OMe                                     --     1 (mix.) MeNH.sub.3     Cl     OMe                                     --     1 (mix.) EtNH.sub.3     Cl     OMe                                     --     1 (mix.) PrNH.sub.3     Cl     OMe                                     --     1 (mix.) .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     1 (mix.) Me             Cl     OMe                                     --     1 (mix.) Et             Cl     OMe                                     --     1 (mix.) .sup.i Pr      Cl     OMe                                     --     1 (mix.) Pr             Cl     OMe                                     --     1 (mix.) Bu             Cl     OMe                                     --     1 (mix.) .sup.i Bu      Cl     OMe                                     --     1 (mix.) .sup.s Bu      Cl     OMe                                     --     1 (mix.) .sup.t Bu      Cl     OMe                                     --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     1 (mix.) H              OCHF.sub.2                                                                           OMe                                     --     1 (mix.) Li             OCHF.sub.2                                                                           OMe                                     --     1 (mix.) Na             OCHF.sub.2                                                                           OMe                                     --     1 (mix.) K              OCHF.sub.2                                                                           OMe                                     --     1 (mix.) 1/2Mg          OCHF.sub.2                                                                           OMe                                     --     1 (mix.) 1/2Ca          OCHF.sub.2                                                                           OMe                                     --     1 (mix.) MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (mix.) EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (mix.) PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (mix.) .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (mix.) Me             OCHF.sub.2                                                                           OMe                                     --     1 (mix.) Et             OCHF.sub.2                                                                           OMe                                     --     1 (mix.) .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     1 (mix.) Pr             OCHF.sub.2                                                                           OMe                                     --     1 (mix.) Bu             OCHF.sub.2                                                                           OMe                                     --     1 (mix.) .sup.i Bu      OCHF.sub.2                                                                           OMe                                     --     1 (mix.) .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     1 (mix.) .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     1 (mix.) H              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) K              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) 1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) 1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub. 2                             --     1 (mix.) Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub. 4Cl-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mix.) H              SMe    OMe                                     --     1 (mix.) Li             SMe    OMe                                     --     1 (mix.) Na             SMe    OMe                                     --     1 (mix.) K              SMe    OMe                                     --     1 (mix.) 1/2Mg          SMe    OMe                                     --     1 (mix.) 1/2Ca          SMe    OMe                                     --     1 (mix.) MeNH.sub. 3    SMe    OMe                                     --     1 (mix.) EtNH.sub.3     SMe    OMe                                     --     1 (mix.) PrNH.sub.3     SMe    OMe                                     --     1 (mix.) .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     1 (mix.) Me             SMe    OMe                                     --     1 (mix.) Et             SMe    OMe                                     --     1 (mix.) .sup.i Pr      SMe    OMe                                     --     1 (mix.) Pr             SMe    OMe                                     --     1 (mix.) Bu             SMe    OMe                                     --     1 (mix.) .sup.i Bu      SMe    OMe                                     --     1 (mix.) .sup.s Bu      SMe    OMe                                     --     1 (mix.) .sup.t Bu      SMe    OMe                                     --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    OMe                                     --     1 (mix.) H              SMe    Me                                      --     1 (mix.) Li             SMe    Me                                      --     1 (mix.) Na             SMe    Me                                      --     1 (mix.) K              SMe    Me                                      --     1 (mix.) 1/2Mg          SMe    Me                                      --     1 (mix.) 1/2Ca          SMe    Me                                      --     1 (mix.) MeNH.sub.3     SMe    Me                                      --     1 (mix.) EtNH.sub.3     SMe    Me                                      --     1 (mix.) PrNH.sub.3     SMe    Me                                      --     1 (mix.) .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     1 (mix.) NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     1 (mix.) Me             SMe    Me                                      --     1 (mix.) Et             SMe    Me                                      --     1 (mix.) .sup.i Pr      SMe    Me                                      --     1 (mix.) Pr             SMe    Me                                      --     1 (mix.) Bu             SMe    Me                                      --     1 (mix.) .sup.i Bu      SMe    Me                                      --     1 (mix.) .sup.s Bu      SMe    Me                                      --     1 (mix.) .sup.t Bu      SMe    Me                                      --     1 (mix.) CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     1 (mix.) CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     1 (mix.) CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     1 (mix.) CH.sub.2 CCH.sub.2                                                                           SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      --     2 (--)   H              Me     Me                                      --     2 (--)   Li             Me     Me                                      --     2 (--)   Na             Me     Me                                      --     2 (--)   K              Me     Me                                      --     2 (--)   1/2Mg          Me     Me                                      --     2 (--)   1/2Ca          Me     Me                                      --     2 (--)   MeNH.sub.3     Me     Me                                      --     2 (--)   EtNH.sub.3     Me     Me                                      --     2 (--)   PrNH.sub.3     Me     Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     2 (--)   Me             Me     Me                                      --     2 (--)   Et             Me     Me                                      --     2 (--)   .sup.i Pr      Me     Me                                      --     2 (--)   Pr             Me     Me                                      --     2 (--)   Bu             Me     Me                                      --     2 (--)   .sup.i Bu      Me     Me                                      --     2 (--)   .sup.s Bu      Me     Me                                      --     2 (--)   .sup.t Bu      Me     Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     2 (--)   H              OMe    Me                                      --     2 (--)   Li             OMe    Me                                      --     2 (--)   Na             OMe    Me                                      --     2 (--)   K              OMe    Me                                      --     2 (--)   1/2Mg          OMe    Me                                      --     2 (--)   1/2Ca          OMe    Me                                      --     2 (--)   MeNH.sub.3     OMe    Me                                      --     2 (--)   EtNH.sub.3     OMe    Me                                      --     2 (--)   PrNH.sub.3     OMe    Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            OMe    Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     2 (--)   Me             OMe    Me                                      --     2 (--)   Et             OMe    Me                                      --     2 (--)   .sup.i Pr      OMe    Me                                      --     2 (--)   Pr             OMe    Me                                      --     2 (--)   Bu             OMe    Me                                      --     2 (--)   .sup.i Bu      OMe    Me                                      --     2 (--)   .sup.s Bu      OMe    Me                                      --     2 (--)   .sup.t Bu      OMe    Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C CH.sub.2                                                                          OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     2 (--)   H              OMe    OMe                                     --     2 (--)   Li             OMe    OMe                                     --     2 (--)   Na             OMe    OMe                                     --     2 (--)   K              OMe    OMe                                     --     2 (--)   1/2Mg          OMe    OMe                                     --     2 (--)   1/2Ca          OMe    OMe                                     --     2 (--)   MeNH.sub.3     OMe    OMe                                     --     2 (--)   EtNH.sub.3     OMe    OMe                                     --     2 (--)   PrNH.sub.3     OMe    OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     --     2 (--)   Me             OMe    OMe                                     --     2 (--)   Et             OMe    OMe                                     --     2 (--)   .sup.i Pr      OMe    OMe                                     --     2 (--)   Pr             OMe    OMe                                     --     2 (--)   Bu             OMe    OMe                                     --     2 (--)   .sup.i Bu      OMe    OMe                                     --     2 (--)   .sup.s Bu      OMe    OMe                                     --     2 (--)   .sup.t Bu      OMe    OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     2 (--)   H              Cl     Me                                      --     2 (--)   Li             Cl     Me                                      --     2 (--)   Na             Cl     Me                                      --     2 (--)   K              Cl     Me                                      --     2 (--)   1/2Mg          Cl     Me                                      --     2 (--)   1/2Ca          Cl     Me                                      --     2 (--)   MeNH.sub.3     Cl     Me                                      --     2 (--)   EtNH.sub.3     Cl     Me                                      --     2 (--)   PrNH.sub.3     Cl     Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Cl     Me                                      --     2 (--)   Me             Cl     Me                                      --     2 (--)   Et             Cl     Me                                      --     2 (--)   .sup.i Pr      Cl     Me                                      --     2 (--)   Pr             Cl     Me                                      --     2 (--)   Bu             Cl     Me                                      --     2 (--)   .sup.i Bu      Cl     Me                                      --     2 (--)   .sup.s Bu      Cl     Me                                      --     2 (--)   .sup.t Bu      Cl     Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     2 (-- )  CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Cl     Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Me                                      --     2 (--)   H              Cl     Cl                                      --     2 (--)   Li             Cl     Cl                                      --     2 (--)   Na             Cl     Cl                                      --     2 (--)   K              Cl     Cl                                      --     2 (--)   1/2Mg          Cl     Cl                                      --     2 (--)   1/2Ca          Cl     Cl                                      --     2 (--)   MeNH.sub.3     Cl     Cl                                      --     2 (--)   EtNH.sub.3     Cl     Cl                                      --     2 (--)   PrNH.sub.3     Cl     Cl                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            Cl     Cl                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     2 (--)   Me             Cl     Cl                                      --     2 (--)   Et             Cl     Cl                                      --     2 (--)   .sup.i Pr      Cl     Cl                                      --     2 (--)   Pr             Cl     Cl                                      --     2 (--)   Bu             Cl     Cl                                      --     2 (--)   .sup.i Bu      Cl     Cl                                      --     2 (--)   .sup.s Bu      Cl     Cl                                      --     2 (--)   .sup.t Bu      Cl     Cl                                      --     2 (--)    CH.sub.2 OCH.sub.3                                                                          Cl     Cl                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Cl                                      --     2 (--)   H              Cl     OMe                                     --     2 (--)   Li             Cl     OMe                                     --     2 (--)   Na             Cl     OMe                                     --     2 (--)   K              Cl     OMe                                     --     2 (--)   1/2Mg          Cl     OMe                                     --     2 (--)   1/2Ca          Cl     OMe                                     --     2 (--)   MeNH.sub.3     Cl     OMe                                     --     2 (--)   EtNH.sub.3     Cl     OMe                                     --     2 (--)   PrNH.sub.3     Cl     OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     2 (--)   Me             Cl     OMe                                     --     2 (--)   Et             Cl     OMe                                     --     2 (--)   .sup.i Pr      Cl     OMe                                     --     2 (--)   Pr             Cl     OMe                                     --     2 (--)   Bu             Cl     OMe                                     --     2 (--)   .sup.i Bu      Cl     OMe                                     --     2 (--)   .sup.s Bu      Cl     OMe                                     --     2 (--)   .sup.t Bu      Cl     OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     2 (--)   H              OCHF.sub.2                                                                           OMe                                     --     2 (--)   Li             OCHF.sub.2                                                                           OMe                                     --     2 (--)   Na             OCHF.sub.2                                                                           OMe                                     --     2 (--)   K              OCHF.sub.2                                                                           OMe                                     --     2 (--)   1/2Mg          OCHF.sub.2                                                                           OMe                                     --     2 (--)   1/2Ca          OCHF.sub.2                                                                           OMe                                     --     2 (--)   MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     2 (--)   EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     2 (--)   PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     2 (--)   Me             OCHF.sub.2                                                                           OMe                                     --     2 (--)   Et             OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     2 (--)   Pr             OCHF.sub.2                                                                           OMe                                     --     2 (--)   Bu             OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.i Bu      OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub. 2                                                                          OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     2 (--)   H              OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   K              OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   H              SMe    OMe                                     --     2 (--)   Li             SMe    OMe                                     --     2 (--)   Na             SMe    OMe                                     --     2 (--)   K              SMe    OMe                                     --     2 (--)   1/2Mg          SMe    OMe                                     --     2 (--)   1/2Ca          SMe    OMe                                     --     2 (--)   MeNH.sub.3     SMe    OMe                                     --     2 (--)   EtNH.sub.3     SMe    OMe                                     --     2 (--)   PrNH.sub.3     SMe    OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     2 (--)   Me             SMe    OMe                                     --     2 (--)   Et             SMe    OMe                                     --     2 (--)   .sup.i Pr      SMe    OMe                                     --     2 (--)   Pr             SMe    OMe                                     --     2 (--)   Bu             SMe    OMe                                     --     2 (--)   .sup.i Bu      SMe    OMe                                     --     2 (--)   .sup.s Bu      SMe    OMe                                     --     2 (--)   .sup.t Bu      SMe    OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    OMe                                     --     2 (--)   H              SMe    Me                                      --     2 (--)   Li             SMe    Me                                      --     2 (--)   Na             SMe    Me                                      --     2 (--)   K              SMe    Me                                      --     2 (--)   1/2Mg          SMe    Me                                      --     2 (--)   1/2Ca          SMe    Me                                      --     2 (--)   MeNH.sub.3     SMe    Me                                      --     2 (--)   EtNH.sub.3     SMe    Me                                      --     2 (--)   PrNH.sub.3     SMe    Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     2 (--)   Me             SMe    Me                                      --     2 (--)   Et             SMe    Me                                      --     2 (--)   .sup.i Pr      SMe    Me                                      --     2 (--)   Pr             SMe    Me                                      --     2 (--)   Bu             SMe    Me                                      --     2 (--)   .sup.i Bu      SMe    Me                                      --     2 (--)   .sup.s Bu      SMe    Me                                      --     2 (--)   .sup.t Bu      SMe    Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      3-Me   1 (cis)  H              Me     Me                                      3-Me   1 (cis)  Na             Me     Me                                      3-Me   1 (cis)  1/2Ca          Me     Me                                      3-Me   1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      3-Me   1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3-Me   1 (cis)  Me             Me     Me                                      3-Me   1 (cis)  Et             Me     Me                                      3-Me   1 (cis)  .sup.i Pr      Me     Me                                      3-Me   1 (cis)  Pr             Me     Me                                      3-Me   1 (cis)  Bu             Me     Me                                      3-Me   1 (cis)  .sup.i Bu      Me     Me                                      3-Me   1 (cis)  .sup.s Bu      Me     Me                                      3-Me   1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3-Me   1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3-Me   1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3-Me   1 (cis)  CH.sub.2 CHCH.sub. 2                                                                         Me     Me                                      3-Me   1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3-Me   1 (cis)  CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3-Me   1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      3-Me   1 (cis)  H              OMe    OMe                                     3-Me   1 (cis)  Na             OMe    OMe                                     3-Me   1 (cis)  1/2Ca          OMe    OMe                                     3-Me   1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3-Me   1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3-Me   1 (cis)  Me             OMe    OMe                                     3-Me   1 (cis)  Et             OMe    OMe                                     3-Me   1 (cis)  .sup.i Pr      OMe    OMe                                     3-Me   1 (cis)  Pr             OMe    OMe                                     3-Me   1 (cis)  Bu             OMe    OMe                                     3-Me   1 (cis)  .sup.i Bu      OMe    OMe                                     3-Me   1 (cis)  .sup.s Bu      OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3-Me   1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub. 4Me-2                                                                OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3-Me   1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3-Me   1 (trans)                                                                              H              Me     Me                                      3-Me   1 (trans)                                                                              Na             Me     Me                                      3-Me   1 (trans)                                                                              1/2Ca          Me     Me                                      3-Me   1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      3-Me   1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3-Me   1 (trans)                                                                              Me             Me     Me                                      3-Me   1 (trans)                                                                              Et             Me     Me                                      3-Me   1 (trans)                                                                              .sup.i Pr      Me     Me                                      3-Me   1 (trans)                                                                              Pr             Me     Me                                      3-Me   1 (trans)                                                                              Bu             Me     Me                                      3-Me   1 (trans)                                                                              .sup.i Bu      Me     Me                                      3-Me   1 (trans)                                                                              .sup.s Bu      Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      3-Me   1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      3-Me   1 (trans)                                                                              H              OMe    OMe                                     3-Me   1 (trans)                                                                              Na             OMe    OMe                                     3-Me   1 (trans)                                                                              1/2Ca          OMe    OMe                                     3-Me   1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3-Me   1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3-Me   1 (trans)                                                                              Me             OMe    OMe                                     3-Me   1 (trans)                                                                              Et             OMe    OMe                                     3-Me   1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     3-Me   1 (trans)                                                                              Pr             OMe    OMe                                     3-Me   1 (trans)                                                                              Bu             OMe    OMe                                     3-Me   1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     3-Me   1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3-Me   1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3-Me   1 (mix.) H              Me     Me                                      3-Me   1 (mix.) Na             Me     Me                                      3-Me   1 (mix.) 1/2Ca          Me     Me                                      3-Me   1 (mix.) .sup.i PrNH.sub.3                                                                            Me     Me                                      3-Me   1 (mix.) NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3-Me   1 (mix.) Me             Me     Me                                      3-Me   1 (mix.) Et             Me     Me                                      3-Me   1 (mix.) .sup.i Pr      Me     Me                                      3-Me   1 (mix.) Pr             Me     Me                                      3-Me   1 (mix.) Bu             Me     Me                                      3-Me   1 (mix.) .sup.i Bu      Me     Me                                      3-Me   1 (mix.) .sup.s Bu      Me     Me                                      3-Me   1 (mix.) CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3-Me   1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3-Me   1 (mix.) CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3-Me   1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      3-Me   1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3-Me   1 (mix.) CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3-Me   1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      3-Me   1 (mix.) H              OMe    OMe                                     3-Me   1 (mix.) Na             OMe    OMe                                     3-Me   1 (mix.) 1/2Ca          OMe    OMe                                     3-Me   1 (mix.) .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3-Me   1 (mix.) NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3-Me   1 (mix.) Me             OMe    OMe                                     3-Me   1 (mix.) Et             OMe    OMe                                     3-Me   1 (mix.) .sup.i Pr      OMe    OMe                                     3-Me   1 (mix.) Pr             OMe    OMe                                     3-Me   1 (mix.) Bu             OMe    OMe                                     3-Me   1 (mix.) .sup.i Bu      OMe    OMe                                     3-Me   1 (mix.) .sup.s Bu      OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3-Me   1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3-Me   1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3-Me   2 (--)   H              Me     Me                                      3-Me   2 (--)   Na             Me     Me                                      3-Me   2 (--)   1/2Ca          Me     Me                                      3-Me   2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      3-Me   2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3-Me   2 (--)   Me             Me     Me                                      3-Me   2 (--)   Et             Me     Me                                      3-Me   2 (--)   .sup.i Pr      Me     Me                                      3-Me   2 (--)   Pr             Me     Me                                      3-Me   2 (--)   Bu             Me     Me                                      3-Me   2 (--)   .sup.i Bu      Me     Me                                      3-Me   2 (--)   .sup.s Bu      Me     Me                                      3-Me   2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3-Me   2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3-Me   2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3-Me   2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      3-Me   2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3-Me   2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4 OMe-3                                                               Me     Me                                      3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3-Me   2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      3-Me   2 (--)   H              OMe    OMe                                     3-Me   2 (--)   Na             OMe    OMe                                     3-Me   2 (--)   1/2Ca          OMe    OMe                                     3-Me   2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3-Me   2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3-Me   2 (--)   Me             OMe    OMe                                     3-Me   2 (--)   Et             OMe    OMe                                     3-Me   2 (--)   .sup.i Pr      OMe    OMe                                     3-Me   2 (--)   Pr             OMe    OMe                                     3-Me   2 (--)   Bu             OMe    OMe                                     3-Me   2 (--)   .sup.i Bu      OMe    OMe                                     3-Me   2 (--)   .sup.s Bu      OMe    OMe                                     3-Me   2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3-Me   2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3-Me   2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3-Me   2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3-Me   2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C CH.sub.2                                                                          OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3-Me   2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-Me   1 (cis)  H              Me     Me                                      4-Me   1 (cis)  Na             Me     Me                                      4-Me   1 (cis)  1/2Ca          Me     Me                                      4-Me   1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      4-Me   1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4-Me   1 (cis)  Me             Me     Me                                      4-Me   1 (cis)  Et             Me     Me                                      4-Me   1 (cis)  .sup.i Pr      Me     Me                                      4-Me   1 (cis)  Pr             Me     Me                                      4-Me   1 (cis)  Bu             Me     Me                                      4-Me   1 (cis)  .sup.i Bu      Me     Me                                      4-Me   1 (cis)  .sup.s Bu      Me     Me                                      4-Me   1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-Me   1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-Me   1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-Me   1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-Me   1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-Me   1 (cis)  CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4 Me-3                                                                Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-Me   1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-Me   1 (cis)  H              OMe    OMe                                     4-Me   1 (cis)  Na             OMe    OMe                                     4-Me   1 (cis)  1/2Ca          OMe    OMe                                     4-Me   1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-Me   1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-Me   1 (cis)  Me             OMe    OMe                                     4-Me   1 (cis)  Et             OMe    OMe                                     4-Me   1 (cis)  .sup.i Pr      OMe    OMe                                     4-Me   1 (cis)  Pr             OMe    OMe                                     4-Me   1 (cis)  Bu             OMe    OMe                                     4-Me   1 (cis)  .sup.i Bu      OMe    OMe                                     4-Me   1 (cis)  .sup.s Bu      OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-Me   1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-Me   1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-Me   1 (trans)                                                                              H              Me     Me                                      4-Me   1 (trans)                                                                              Na             Me     Me                                      4-Me   1 (trans)                                                                              1/2Ca          Me     Me                                      4-Me   1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      4-Me   1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4-Me   1 (trans)                                                                              Me             Me     Me                                      4-Me   1 (trans)                                                                              Et             Me     Me                                      4-Me   1 (trans)                                                                              .sup.i Pr      Me     Me                                      4-Me   1 (trans)                                                                              Pr             Me     Me                                      4-Me   1 (trans)                                                                              Bu             Me     Me                                      4-Me   1 (trans)                                                                              .sup.i Bu      Me     Me                                      4-Me   1 (trans)                                                                              .sup.s Bu      Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-Me   1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-Me   1 (trans)                                                                              H              OMe    OMe                                     4-Me   1 (trans)                                                                              Na             OMe    OMe                                     4-Me   1 (trans)                                                                              1/2Ca          OMe    OMe                                     4-Me   1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-Me   1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-Me   1 (trans)                                                                              Me             OMe    OMe                                     4-Me   1 (trans)                                                                              Et             OMe    OMe                                     4-Me   1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     4-Me   1 (trans)                                                                              Pr             OMe    OMe                                     4-Me   1 (trans)                                                                              Bu             OMe    OMe                                     4-Me   1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     4-Me   1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-Me   1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-Me   1 (mix.) H              Me     Me                                      4-Me   1 (mix.) Na             Me     Me                                      4-Me   1 (mix.) 1/2Ca          Me     Me                                      4-Me   1 (mix.) .sup.i PrNH.sub.3                                                                            Me     Me                                      4-Me   1 (mix.) NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4-Me   1 (mix.) Me             Me     Me                                      4-Me   1 (mix.) Et             Me     Me                                      4-Me   1 (mix.) .sup.i Pr      Me     Me                                      4-Me   1 (mix.) Pr             Me     Me                                      4-Me   1 (mix.) Bu             Me     Me                                      4-Me   1 (mix.) .sup.i Bu      Me     Me                                      4-Me   1 (mix.) .sup.s Bu      Me     Me                                      4-Me   1 (mix.) CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-Me   1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-Me   1 (mix.) CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-Me   1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-Me   1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-Me   1 (mix.) CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub. 6 H.sub.4Me-2                                                                Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-Me   1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-Me   1 (mix.) H              OMe    OMe                                     4-Me   1 (mix.) Na             OMe    OMe                                     4-Me   1 (mix.) 1/2Ca          OMe    OMe                                     4-Me   1 (mix.) .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-Me   1 (mix.) NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-Me   1 (mix.) Me             OMe    OMe                                     4-Me   1 (mix.) Et             OMe    OMe                                     4-Me   1 (mix.) .sup.i Pr      OMe    OMe                                     4-Me   1 (mix.) Pr             OMe    OMe                                     4-Me   1 (mix.) Bu             OMe    OMe                                     4-Me   1 (mix.) .sup.i Bu      OMe    OMe                                     4-Me   1 (mix.) .sup.s Bu      OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-Me   1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-Me   1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-Me   2 (--)   H              Me     Me                                      4-Me   2 (--)   Na             Me     Me                                      4-Me   2 (--)   1/2Ca          Me     Me                                      4-Me   2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      4-Me   2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4-Me   2 (--)   Me             Me     Me                                      4-Me   2 (--)   Et             Me     Me                                      4-Me   2 (--)   .sup.i Pr      Me     Me                                      4-Me   2 (--)   Pr             Me     Me                                      4-Me   2 (--)   Bu             Me     Me                                      4-Me   2 (--)   .sup.i Bu      Me     Me                                      4-Me   2 (--)   .sup.s Bu      Me     Me                                      4-Me   2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-Me   2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-Me   2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-Me   2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-Me   2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-Me   2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-Me   2 (--)    CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-Me   2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-Me   2 (--)   H              OMe    OMe                                     4-Me   2 (--)   Na             OMe    OMe                                     4-Me   2 (--)   1/2Ca          OMe    OMe                                     4-Me   2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-Me   2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-Me   2 (--)   Me             OMe    OMe                                     4-Me   2 (--)   Et             OMe    OMe                                     4-Me   2 (--)   .sup.i Pr      OMe    OMe                                     4-Me   2 (--)   Pr             OMe    OMe                                     4-Me   2 (--)   Bu             OMe    OMe                                     4-Me   2 (--)   .sup.i Bu      OMe    OMe                                     4-Me   2 (--)   .sup.s Bu      OMe    OMe                                     4-Me   2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-Me   2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-Me   2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-Me   2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-Me   2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-Me   2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-Me   2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     5-Me   1 (cis)  H              Me     Me                                      5-Me   1 (cis)  Na             Me     Me                                      5-Me   1 (cis)  1/2Ca          Me     Me                                      5-Me   1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      5-Me   1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      5-Me   1 (cis)  Me             Me     Me                                      5-Me   1 (cis)  Et             Me     Me                                      5-Me   1 (cis)  .sup.i Pr      Me     Me                                      5-Me   1 (cis)  Pr             Me     Me                                      5-Me   1 (cis)  Bu             Me     Me                                      5-Me   1 (cis)  .sup.i Bu      Me     Me                                      5-Me   1 (cis)  .sup.s Bu      Me     Me                                      5-Me   1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      5-Me   1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      5-Me   1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      5-Me   1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      5-Me   1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      5-Me   1 (cis)   CH.sub.2 CCH.sub.2                                                                          Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      5-Me   1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      5-Me   1 (cis)  H              OMe    OMe                                     5-Me   1 (cis)  Na             OMe    OMe                                     5-Me   1 (cis)  1/2Ca          OMe    OMe                                     5-Me   1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     5-Me   1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5-Me   1 (cis)  Me             OMe    OMe                                     5-Me   1 (cis)  Et             OMe    OMe                                     5-Me   1 (cis)  .sup.i Pr      OMe    OMe                                     5-Me   1 (cis)  Pr             OMe    OMe                                     5-Me   1 (cis)  Bu             OMe    OMe                                     5-Me   1 (cis)  .sup.i Bu      OMe    OMe                                     5-Me   1 (cis)  .sup.s Bu      OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5-Me   1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5-Me   1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     5-Me   1 (trans)                                                                              H              Me     Me                                      5-Me   1 (trans)                                                                              Na             Me     Me                                      5-Me   1 (trans)                                                                              1/2Ca          Me     Me                                      5-Me   1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      5-Me   1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      5-Me   1 (trans)                                                                              Me             Me     Me                                      5-Me   1 (trans)                                                                              Et             Me     Me                                      5-Me   1 (trans)                                                                              .sup.i Pr      Me     Me                                      5-Me   1 (trans)                                                                              Pr             Me     Me                                      5-Me   1 (trans)                                                                              Bu             Me     Me                                      5-Me   1 (trans)                                                                              .sup.i Bu      Me     Me                                      5-Me   1 (trans)                                                                              .sup.s Bu      Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      5-Me   1 (trans)                                                                              C(CH.sub.3).sub.2 CH CH.sub.2                                                                Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      5-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      5-Me   1 (trans)                                                                              H              OMe    OMe                                     5-Me   1 (trans)                                                                              Na             OMe    OMe                                     5-Me   1 (trans)                                                                              1/2Ca          OMe    OMe                                     5-Me   1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     5-Me   1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5-Me   1 (trans)                                                                              Me             OMe    OMe                                     5-Me   1 (trans)                                                                              Et             OMe    OMe                                     5-Me   1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     5-Me   1 (trans)                                                                              Pr             OMe    OMe                                     5-Me   1 (trans)                                                                              Bu             OMe    OMe                                     5-Me   1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     5-Me   1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5-Me   1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5-Me   1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     5-Me   1 (mixt.)                                                                              H              Me     Me                                      5-Me   1 (mixt.)                                                                              Na             Me     Me                                      5-Me   1 (mixt.)                                                                              1/2Ca          Me     Me                                      5-Me   1 (mixt.)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      5-Me   1 (mixt.)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      5-Me   1 (mixt.)                                                                              Me             Me     Me                                      5-Me   1 (mixt.)                                                                              Et             Me     Me                                      5-Me   1 (mixt.)                                                                              .sup.i Pr      Me     Me                                      5-Me   1 (mixt.)                                                                              Pr             Me     Me                                      5-Me   1 (mixt.)                                                                              Bu             Me     Me                                      5-Me   1 (mixt.)                                                                              .sup.i Bu      Me     Me                                      5-Me   1 (mixt.)                                                                              .sup.s Bu      Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      5-Me   1 (mixt.)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      5-Me   1 (mixt.)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      5-Me   1 (mixt.)                                                                              H              OMe    OMe                                     5-Me   1 (mixt.)                                                                              Na             OMe    OMe                                     5-Me   1 (mixt.)                                                                              1/2Ca          OMe    OMe                                     5-Me   1 (mixt.)                                                                              .sup.i PrNH.sub. 3                                                                           OMe    OMe                                     5-Me   1 (mixt.)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5-Me   1 (mixt.)                                                                              Me             OMe    OMe                                     5-Me   1 (mixt.)                                                                              Et             OMe    OMe                                     5-Me   1 (mixt.)                                                                              .sup.i Pr      OMe    OMe                                     5-Me   1 (mixt.)                                                                              Pr             OMe    OMe                                     5-Me   1 (mixt.)                                                                              Bu             OMe    OMe                                     5-Me   1 (mixt.)                                                                              .sup.i Bu      OMe    OMe                                     5-Me   1 (mixt.)                                                                              .sup.s Bu      OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5-Me   1 (mixt.)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5-Me   1 (mixt.)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     5-Me   2 (--)   H              Me     Me                                      5-Me   2 (--)   Na             Me     Me                                      5-Me   2 (--)   1/2Ca          Me     Me                                      5-Me   2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      5-Me   2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      5-Me   2 (--)   Me             Me     Me                                      5-Me   2 (--)   Et             Me     Me                                      5-Me   2 (--)   .sup.i Pr      Me     Me                                      5-Me   2 (--)   Pr             Me     Me                                      5-Me   2 (--)   Bu             Me     Me                                      5-Me   2 (--)   .sup.i Bu      Me     Me                                      5-Me   2 (--)   .sup.s Bu      Me     Me                                      5-Me   2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      5-Me   2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      5-Me   2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      5-Me   2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      5-Me   2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      5-Me   2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      5-Me   2 (-- )  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      5-Me   2 (--)   H              OMe    OMe                                     5-Me   2 (--)   Na             OMe    OMe                                     5-Me   2 (--)   1/2Ca          OMe    OMe                                     5-Me   2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     5-Me   2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5-Me   2 (--)   Me             OMe    OMe                                     5-Me   2 (--)   Et             OMe    OMe                                     5-Me   2 (--)   .sup.i Pr      OMe    OMe                                     5-Me   2 (--)   Pr             OMe    OMe                                     5-Me   2 (--)   Bu             OMe    OMe                                     5-Me   2 (--)   .sup.i Bu      OMe    OMe                                     5-Me   2 (--)   .sup.s Bu      OMe    OMe                                     5-Me   2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5-Me   2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5-Me   2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5-Me   2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5-Me   2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5-Me   2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     5-Me   2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5-Me   2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  H              Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  Na             Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  1/2Ca          Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  Me             Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  Et             Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  .sup.i Pr      Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  Pr             Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  Bu             Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  .sup.i Bu      Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  .sup.s Bu      Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      3.3-(Me).sub.2                                                                       1 (cis)  H              OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  Na             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  1/2Ca          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  Me             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  Et             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  .sup.i Pr      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  Pr             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  Bu             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  .sup.i Bu      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  .sup.s Bu      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.3-(Me).sub. 2                                                                      1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              H              Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              Na             Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              1/2Ca          Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              Me             Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              Et             Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Pr      Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              Pr             Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              Bu             Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Bu      Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.s Bu      Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub. 5                                                                    Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      3.3-(Me).sub.2                                                                       1 (trans)                                                                              H              OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              Na             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              1/2Ca          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              Me             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              Et             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              Pr             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              Bu             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub. 6 H.sub.4Me-3                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) H              Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) Na             Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) 1/2Ca          Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) .sup.i PrNH.sub.3                                                                            Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) Me             Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) Et             Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) .sup.i Pr      Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) Pr             Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) Bu             Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) .sup.i Bu      Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) .sup.s Bu      Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                           Me     Me                                      3.3-(Me).sub.2                                                                       1 (mix.) H              OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) Na             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) 1/2Ca          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) Me             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) Et             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) .sup.i Pr      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) Pr             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) Bu             OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) .sup.i Bu      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) .sup.s Bu      OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   H              Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   Na             Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   1/2Ca          Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   Me             Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   Et             Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   .sup.i Pr      Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   Pr             Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   Bu             Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   .sup.i Bu      Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   .sup.s Bu      Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      3.3-(Me).sub. 2                                                                      2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      3.3-(Me).sub.2                                                                       2 (--)   H              OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   Na             OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   1/2Ca          OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   Me             OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   Et             OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   .sup.i Pr      OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   Pr             OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   Bu             OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   .sup. i Bu     OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   .sup.s Bu      OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub. 6 H.sub.4Me-4                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.3-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  H              Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  Na             Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  1/2Ca          Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  Me             Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  Et             Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  .sup.i Pr      Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  Pr             Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  Bu             Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  .sup.i Bu      Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  .sup.s Bu      Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub. 2                                                                      1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4.4-(Me).sub.2                                                                       1 (cis)  H              OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  Na             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  1/2Ca          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  Me             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  Et             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  .sup.i Pr      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  Pr             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  Bu             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  .sup.i Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  .sup.s Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub. 6 H.sub.4Cl-2                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              H              Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              Na             Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              1/2Ca          Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              Me             Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              Et             Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Pr      Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              Pr             Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              Bu             Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Bu      Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.s Bu      Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                               CH.sub.2 C.sub.6 H.sub.4Me-4                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4.4-(Me).sub.2                                                                       1 (trans)                                                                              H              OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              Na             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              1/2Ca          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              Me             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              Et             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              Pr             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              Bu             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4.4-(Me).sub. 2                                                                      1 (mix.) H              Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) Na             Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) 1/2Ca          Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) .sup.i PrNH.sub.3                                                                            Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) Me             Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) Et             Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) .sup.i Pr      Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) Pr             Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) Bu             Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) .sup.i Bu      Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) .sup.s Bu      Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4.4-(Me).sub.2                                                                       1 (mix.) H              OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) Na             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) 1/2Ca          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) Me             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) Et             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) .sup.i Pr      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) Pr             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) Bu             OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) .sup.i Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) .sup.s Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub. 2 C.sub.6 H.sub.4Me-4                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   H              Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   Na             Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   1/2Ca          Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   Me             Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   Et             Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   .sup.i Pr      Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   Pr             Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   Bu             Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   .sup.i Bu      Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   .sup.s Bu      Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4.4-(Me).sub.2                                                                       2 (-- )  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4.4-(Me).sub.2                                                                       2 (--)   H              OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   Na             OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   1/2Ca          OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   Me             OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   Et             OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   .sup.i Pr      OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   Pr             OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   Bu             OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   .sup.i Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   .sup.s Bu      OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4.4-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  H              Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  Na             Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  1/2Ca          Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  Me             Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  Et             Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  .sup.i Pr      Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  Pr             Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  Bu             Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  .sup.i Bu      Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  .sup.s Bu      Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C CH.sub.2                                                                          Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-.sup.t Bu                                                                          1 (cis)  H              OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  Na             OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  1/2Ca          OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  Me             OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  Et             OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  .sup.i Pr      OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  Pr             OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  Bu             OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  .sup.i Bu      OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  .sup.s Bu      OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              H              Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              Na             Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              1/2Ca          Me     Me                                      4-.sup. t Bu                                                                         1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              Me             Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              Et             Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              .sup.i Pr      Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              Pr             Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              Bu             Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              .sup.i Bu      Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              .sup.s Bu      Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-.sup.t Bu                                                                          1 (trans)                                                                              H              OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              Na             OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              1/2Ca          OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              Me             OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              Et             OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              Pr             OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              Bu             OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub. 2 C.sub.6 H.sub.4Cl-2                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) H              Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) Na             Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) 1/2Ca          Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) .sup.i PrNH.sub.3                                                                            Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) NH.sub. 2 CONH.sub.3                                                                         Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) Me             Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) Et             Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) .sup.i Pr      Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) Pr             Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) Bu             Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) .sup.i Bu      Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) .sup.s Bu      Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-.sup. t Bu                                                                         1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-.sup.t Bu                                                                          1 (mix.) H              OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) Na             OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) 1/2Ca          OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) Me             OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) Et             OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) .sup.i Pr      OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) Pr             OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) Bu             OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) .sup.i Bu      OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) .sup.s Bu      OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub. 6 H.sub.4Cl-3                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-.sup.t Bu                                                                          1 (mix.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   H              Me     Me                                      4-.sup.t Bu                                                                          2 (--)   Na             Me     Me                                      4-.sup.t Bu                                                                          2 (--)   1/2Ca          Me     Me                                      4-.sup.t Bu                                                                          2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      4-.sup.t Bu                                                                          2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      4-.sup.t Bu                                                                          2 (--)   Me             Me     Me                                      4-.sup.t Bu                                                                          2 (--)   Et             Me     Me                                      4-.sup.t Bu                                                                          2 (--)   .sup.i Pr      Me     Me                                      4-.sup.t Bu                                                                          2 (--)   Pr             Me     Me                                      4-.sup.t Bu                                                                          2 (--)   Bu             Me     Me                                      4-.sup.t Bu                                                                          2 (--)   .sup.i Bu      Me     Me                                      4-.sup.t Bu                                                                          2 (--)   .sup.s Bu      Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      4-.sup.t Bu                                                                          2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      4-.sup.t Bu                                                                          2 (--)   H              OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   Na             OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   1/2Ca          OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     4-.sup. t Bu                                                                         2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   Me             OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   Et             OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   .sup.i Pr      OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   Pr             OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   Bu             OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   .sup.i Bu      OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   .sup.s Bu      OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     4-.sup.t Bu                                                                          2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     ______________________________________                                    

                                      TABLE                                       __________________________________________________________________________    A compound of the general formula:                                             ##STR26##                                                                    In the below-mentioned table, Me represents methyl                            group, Et represents ethyl group, Pr represents propyl                        group, .sup.i Pr represents isopropyl group, Bu represents butyl              group, .sup.i Bu represents isobutyl group, .sup.s Bu represents              secondary butyl group, .sup.t Bu represents tertiary butyl                    group, cis represents a cis-form, trans represents a                          trans-form, mix. represents a mixture of a cis-form and                       a trans-form, 1 represents a single bond and 2 represents                     a double bond.                                                                (X).sub.m    R            R.sup.1                                                                             R.sup.2                                       __________________________________________________________________________    --     1 (cis)                                                                             H            Me    Me                                            --     1 (cis)                                                                             Li           Me    Me                                            --     1 (cis)                                                                             Na           Me    Me                                            --     1 (cis)                                                                             K            Me    Me                                            --     1 (cis)                                                                             1/2Mg        Me    Me                                            --     1 (cis)                                                                             1/2Ca        Me    Me                                            --     1 (cis)                                                                             MeNH.sub.3   Me    Me                                            --     1 (cis)                                                                             EtNH.sub.3   Me    Me                                            --     1 (cis)                                                                             PrNH.sub.3   Me    Me                                            --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            --     1 (cis)                                                                             Me           Me    Me                                            --     1 (cis)                                                                             Et           Me    Me                                            --     1 (cis)                                                                             .sup.i Pr    Me    Me                                            --     1 (cis)                                                                             Pr           Me    Me                                            --     1 (cis)                                                                             Bu           Me    Me                                            --     1 (cis)                                                                             .sup.i Bu    Me    Me                                            --     1 (cis)                                                                             .sup.s Bu    Me    Me                                            --     1 (cis)                                                                             .sup.t Bu    Me    Me                                            --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            --     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                              Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-3                                                              Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-4                                                              Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-2                                                             Me    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-3                                                             Me    Me                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            --     1 (cis)                                                                             H            OMe   Me                                            --     1 (cis)                                                                             Li           OMe   Me                                            --     1 (cis)                                                                             Na           OMe   Me                                            --     1 (cis)                                                                             K            OMe   Me                                            --     1 (cis)                                                                             1/2Mg        OMe   Me                                            --     1 (cis)                                                                             1/2Ca        OMe   Me                                            --     1 (cis)                                                                             MeNH.sub.3   OMe   Me                                            --     1 (cis)                                                                             EtNH.sub.3   OMe   Me                                            --     1 (cis)                                                                             PrNH.sub.3   OMe   Me                                            --     1 (cis)                                                                             .sup.i PrNH.sup.3                                                                          OMe   Me                                            --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   Me                                            --     1 (cis)                                                                             Me           OMe   Me                                            --     1 (cis)                                                                             Et           OMe   Me                                            --     1 (cis)                                                                             .sup.i Pr    OMe   Me                                            --     1 (cis)                                                                             Pr           OMe   Me                                            --     1 (cis)                                                                             Bu           OMe   Me                                            --     1 (cis)                                                                             .sup.i Bu    OMe   Me                                            --     1 (cis)                                                                             .sup.s Bu    OMe   Me                                            --     1 (cis)                                                                             .sup.t Bu    OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   Me                                            --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                              OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-3                                                              OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-4                                                              OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-2                                                             OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-3                                                             OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-4                                                             OMe   Me                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   Me                                            --     1 (cis)                                                                             H            OMe   OMe                                           --     1 (cis)                                                                             Li           OMe   OMe                                           --     1 (cis)                                                                             Na           OMe   OMe                                           --     1 (cis)                                                                             K            OMe   OMe                                           --     1 (cis)                                                                             1/2Mg        OMe   OMe                                           --     1 (cis)                                                                             1/2Ca        OMe   OMe                                           --     1 (cis)                                                                             MeNH.sub.3   OMe   OMe                                           --     1 (cis)                                                                             EtNH.sub.3   OMe   OMe                                           --     1 (cis)                                                                             PrNH.sub.3   OMe   OMe                                           --     1 (cis)                                                                             .sup.i PrNH.sup.3                                                                          OMe   OMe                                           --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           --     1 (cis)                                                                             Me           OMe   OMe                                           --     1 (cis)                                                                             Et           OMe   OMe                                           --     1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           --     1 (cis)                                                                             Pr           OMe   OMe                                           --     1 (cis)                                                                             Bu           OMe   OMe                                           --     1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           --     1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           --     1 (cis)                                                                             .sup.t Bu    OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2 OMe                                                                    OMe                                                 --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           --     1 (cis)                                                                             CH.sub. 2 C.sub.6 H.sub.4 Cl-2                                                             OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-3                                                              OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-4                                                              OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-4                                                             OMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           --     1 (cis)                                                                             H            Cl    Me                                            --     1 (cis)                                                                             Li           Cl    Me                                            --     1 (cis)                                                                             Na           Cl    Me                                            --     1 (cis)                                                                             K            Cl    Me                                            --     1 (cis)                                                                             1/2Mg        Cl    Me                                            --     1 (cis)                                                                             1/2Ca        Cl    Me                                            --     1 (cis)                                                                             MeNH.sub.3   Cl    Me                                            --     1 (cis)                                                                             EtNH.sub.3   Cl    Me                                            --     1 (cis)                                                                             PrNH.sub.3   Cl    Me                                            --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Cl    Me                                            --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Cl    Me                                            --     1 (cis)                                                                             Me           Cl    Me                                            --     1 (cis)                                                                             Et           Cl    Me                                            --     1 (cis)                                                                             .sup.i Pr    Cl    Me                                            --     1 (cis)                                                                             Pr           Cl    Me                                            --     1 (cis)                                                                             Bu           Cl    Me                                            --     1 (cis)                                                                             .sup.i Bu    Cl    Me                                            --     1 (cis)                                                                             .sup.s Bu    Cl    Me                                            --     1 (cis)                                                                             .sup.t Bu    Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Cl    Me                                            --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Me                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    Me                                            --     1 (cis)                                                                             H            Cl    Cl                                            --     1 (cis)                                                                             Li           Cl    Cl                                            --     1 (cis)                                                                             Na           Cl    Cl                                            --     1 (cis)                                                                             K            Cl    Cl                                            --     1 (cis)                                                                             1/2Mg        Cl    Cl                                            --     1 (cis)                                                                             1/2Ca        Cl    Cl                                            --     1 (cis)                                                                             MeNH.sub.3   Cl    Cl                                            --     1 (cis)                                                                             EtNH.sub.3   Cl    Cl                                            --     1 (cis)                                                                             PrNH.sub.3   Cl    Cl                                            --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Cl    Cl                                            --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Cl    Cl                                            --     1 (cis)                                                                             Me           Cl    Cl                                            --     1 (cis)                                                                             Et           Cl    Cl                                            --     1 (cis)                                                                             .sup.i Pr    Cl    Cl                                            --     1 (cis)                                                                             Pr           Cl    Cl                                            --     1 (cis)                                                                             Bu           Cl    Cl                                            --     1 (cis)                                                                             .sup.i Bu    Cl    Cl                                            --     1 (cis)                                                                             .sup.s Bu    Cl    Cl                                            --     1 (cis)                                                                             .sup.t Bu    Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Cl    Cl                                            --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2                                                                          Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Cl                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    Cl                                            --     1 (cis)                                                                             H            Cl    OMe                                           --     1 (cis)                                                                             Li           Cl    OMe                                           --     1 (cis)                                                                             Na           Cl    OMe                                           --     1 (cis)                                                                             K            Cl    OMe                                           --     1 (cis)                                                                             1/2Mg        Cl    OMe                                           --     1 (cis)                                                                             1/2Ca        Cl    OMe                                           --     1 (cis)                                                                             MeNH.sub.3   Cl    OMe                                           --     1 (cis)                                                                             EtNH.sub.3   Cl    OMe                                           --     1 (cis)                                                                             PrNH.sub.3   Cl    OMe                                           --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Cl    OMe                                           --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Cl    OMe                                           --     1 (cis)                                                                             Me           Cl    OMe                                           --     1 (cis)                                                                             Et           Cl    OMe                                           --     1 (cis)                                                                             .sup.i Pr    Cl    OMe                                           --     1 (cis)                                                                             Pr           Cl    OMe                                           --     1 (cis)                                                                             Bu           Cl    OMe                                           --     1 (cis)                                                                             .sup.i Bu    Cl    OMe                                           --     1 (cis)                                                                             .sup.s Bu    Cl    OMe                                           --     1 (cis)                                                                             .sup.t Bu    Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 CH.sub.2 SCH.sub.3                                                                Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Cl    OMe                                           --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    OMe                                           --     1 (cis)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                              Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    OMe                                           --     1 (cis)                                                                             H            OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             Li           OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             Na           OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             K            OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             1/2Mg        OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             1/2Ca        OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             MeNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             EtNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             PrNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             Me           OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             Et           OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             .sup.i Pr    OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             Pr           OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             Bu           OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             .sup.i Bu    OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             .sup.s Bu    OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             .sup.t Bu    OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             C(CH.sub.2).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub. 2 C.sub.6 H.sub.4Cl-3                                                              OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OCHF.sub.2                                                                          OMe                                           --     1 (cis)                                                                             H            OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             Li           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             Na           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             K            OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             1/2Mg        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             1/2Ca        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             MeNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             EtNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             PrNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             Me           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             Et           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             .sup.i Pr    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             Pr           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             Bu           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             .sup.i Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             .sup.s Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             .sup.t Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C CH.sub.2                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (cis)                                                                             H            SMe   OMe                                           --     1 (cis)                                                                             Li           SMe   OMe                                           --     1 (cis)                                                                             Na           SMe   OMe                                           --     1 (cis)                                                                             K            SMe   OMe                                           --     1 (cis)                                                                             1/2Mg        SMe   OMe                                           --     1 (cis)                                                                             1/2Ca        SMe   OMe                                           --     1 (cis)                                                                             MeNH.sub.3   SMe   OMe                                           --     1 (cis)                                                                             EtNH.sub.3   SMe   OMe                                           --     1 (cis)                                                                             PrNH.sub.3   SMe   OMe                                           --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          SMe   OMe                                           --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        SMe   OMe                                           --     1 (cis)                                                                             Me           SMe   OMe                                           --     1 (cis)                                                                             Et           SMe   OMe                                           --     1 (cis)                                                                             .sup.i Pr    SMe   OMe                                           --     1 (cis)                                                                             Pr           SMe   OMe                                           --     1 (cis)                                                                             Bu           SMe   OMe                                           --     1 (cis)                                                                             .sup.i Bu    SMe   OMe                                           --     1 (cis)                                                                             .sup.s Bu    SMe   OMe                                           --     1 (cis)                                                                             .sup.t Bu    SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 CH.sub.2 SCH.sub.3                                                                SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        SMe   OMe                                           --     1 (cis)                                                                             C(CH.sub.2).sub.2 CHCH.sub. 2                                                              SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   OMe                                           --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   OMe                                           --     1 (cis)                                                                             H            SMe   Me                                            --     1 (cis)                                                                             Li           SMe   Me                                            --     1 (cis)                                                                             Na           SMe   Me                                            --     1 (cis)                                                                             K            SMe   Me                                            --     1 (cis)                                                                             1/2Mg        SMe   Me                                            --     1 (cis)                                                                             1/2Ca        SMe   Me                                            --     1 (cis)                                                                             MeNH.sub.3   SMe   Me                                            --     1 (cis)                                                                             EtNH.sub.3   SMe   Me                                            --     1 (cis)                                                                             PrNH.sub.3   SMe   Me                                            --     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          SMe   Me                                            --     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        SMe   Me                                            --     1 (cis)                                                                             Me           SMe   Me                                            --     1 (cis)                                                                             Et           SMe   Me                                            --     1 (cis)                                                                             .sup.i Pr    SMe   Me                                            --     1 (cis)                                                                             Pr           SMe   Me                                            --     1 (cis)                                                                             Bu           SMe   Me                                            --     1 (cis)                                                                             .sup.i Bu    SMe   Me                                            --     1 (cis)                                                                             .sup.s Bu    SMe   Me                                            --     1 (cis)                                                                             .sup.t Bu    SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        SMe   Me                                            --     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   Me                                            --     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   Me                                            --     1 (trans)                                                                           H            Me    Me                                            --     1 (trans)                                                                           Li           Me    Me                                            --     1 (trans)                                                                           Na           Me    Me                                            --     1 (trans)                                                                           K            Me    Me                                            --     1 (trans)                                                                           1/2Mg        Me    Me                                            --     1 (trans)                                                                           1/2Ca        Me    Me                                            --     1 (trans)                                                                           MeNH.sub.3   Me    Me                                            --     1 (trans)                                                                           EtNH.sub.3   Me    Me                                            --     1 (trans)                                                                           PrNH.sub.3   Me    Me                                            --     1 (trans)                                                                           PrNH.sub.3   OMe   Me                                            --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   Me                                            --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   Me                                            --     1 (trans)                                                                           Me           OMe   Me                                            --     1 (trans)                                                                           Et           OMe   Me                                            --     1 (trans)                                                                           .sup.i Pr    OMe   Me                                            --     1 (trans)                                                                           Pr           OMe   Me                                            --     1 (trans)                                                                           Bu           OMe   Me                                            --     1 (trans)                                                                           .sup.i Bu    OMe   Me                                            --     1 (trans)                                                                           .sup.s Bu    OMe   Me                                            --     1 (trans)                                                                           .sup.t Bu    OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   Me                                            --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   Me                                            --     1 (trans)                                                                           H            OMe   OMe                                           --     1 (trans)                                                                           Li           OMe   OMe                                           --     1 (trans)                                                                           Na           OMe   OMe                                           --     1 (trans)                                                                           K            OMe   OMe                                           --     1 (trans)                                                                           1/2Mg        OMe   OMe                                           --     1 (trans)                                                                           1/2Ca        OMe   OMe                                           --     1 (trans)                                                                           MeNH.sub.3   OMe   OMe                                           --     1 (trans)                                                                           EtNH.sub.3   OMe   OMe                                           --     1 (trans)                                                                           PrNH.sub. 3  OMe   OMe                                           --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           --     1 (trans)                                                                           Me           OMe   OMe                                           --     1 (trans)                                                                           Et           OMe   OMe                                           --     1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           --     1 (trans)                                                                           Pr           OMe   OMe                                           --     1 (trans)                                                                           Bu           OMe   OMe                                           --     1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           --     1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           --     1 (trans)                                                                           .sup.t Bu    OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           --     1 (trans)                                                                           H            Cl    Me                                            --     1 (trans)                                                                           Li           Cl    Me                                            --     1 (trans)                                                                           Na           Cl    Me                                            --     1 (trans)                                                                           K            Cl    Me                                            --     1 (trans)                                                                           1/2Mg        Cl    Me                                            --     1 (trans)                                                                           1/2Ca        Cl    Me                                            --     1 (trans)                                                                           MeNH.sub.3   Cl    Me                                            --     1 (trans)                                                                           EtNH.sub.3   Cl    Me                                            --     1 (trans)                                                                           PrNH.sub.3   Cl    Me                                            --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Cl    Me                                            --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Cl    Me                                            --     1 (trans)                                                                           Me           Cl    Me                                            --     1 (trans)                                                                           Et           Cl    Me                                            --     1 (trans)                                                                           .sup.i Pr    Cl    Me                                            --     1 (trans)                                                                           Pr           Cl    Me                                            --     1 (trans)                                                                           Bu           Cl    Me                                            --     1 (trans)                                                                           .sup.i Bu    Cl    Me                                            --     1 (trans)                                                                           .sup.s Bu    Cl    Me                                            --     1 (trans)                                                                           .sup.t Bu    Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Cl    Me                                            --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Me                                            --     1 (trans)                                                                           H            Cl    Cl                                            --     1 (trans)                                                                           Li           Cl    Cl                                            --     1 (trans)                                                                           Na           Cl    Cl                                            --     1 (trans)                                                                           K            Cl    Cl                                            --     1 (trans)                                                                           1/2Mg        Cl    Cl                                            --     1 (trans)                                                                           1/2Ca        Cl    Cl                                            --     1 (trans)                                                                           MeNH.sub.3   Cl    Cl                                            --     1 (trans)                                                                           EtNH.sub.3   Cl    Cl                                            --     1 (trans)                                                                           PrNH.sub.3   Cl    Cl                                            --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Cl    Cl                                            --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Cl    Cl                                            --     1 (trans)                                                                           Me           Cl    Cl                                            --     1 (trans)                                                                           Et           Cl    Cl                                            --     1 (trans)                                                                           .sup.i Pr    Cl    Cl                                            --     1 (trans)                                                                           Pr           Cl    Cl                                            --     1 (trans)                                                                           Bu           Cl    Cl                                            --     1 (trans)                                                                           .sup.i Bu    Cl    Cl                                            --     1 (trans)                                                                           .sup.s Bu    Cl    Cl                                            --     1 (trans)                                                                           .sup.t Bu    Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Cl    Cl                                            --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Cl                                            --     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    Cl                                            --     1 (trans)                                                                           H            Cl    OMe                                           --     1 (trans)                                                                           Li           Cl    OMe                                           --     1 (trans)                                                                           Na           Cl    OMe                                           --     1 (trans)                                                                           K            Cl    OMe                                           --     1 (trans)                                                                           1/2Mg        Cl    OMe                                           --     1 (trans)                                                                           1/2Ca        Cl    OMe                                           --     1 (trans)                                                                           MeNH.sub.3   Cl    OMe                                           --     1 (trans)                                                                           EtNH.sub.3   Cl    OMe                                           --     1 (trans)                                                                           PrNH.sub.3   Cl    OMe                                           --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Cl    OMe                                           --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Cl    OMe                                           --     1 (trans)                                                                           Me           Cl    OMe                                           --     1 (trans)                                                                           Et           Cl    OMe                                           --     1 (trans)                                                                           .sup.i Pr    Cl    OMe                                           --     1 (trans)                                                                           Pr           Cl    OMe                                           --     1 (trans)                                                                           Bu           Cl    OMe                                           --     1 (trans)                                                                           .sup.i Bu    Cl    OMe                                           --     1 (trans)                                                                           .sup.s Bu    Cl    OMe                                           --     1 (trans)                                                                           .sup.t Bu    Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Cl    OMe                                           --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    OMe                                           --     1 (trans)                                                                           H            OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           Li           OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           Na           OCHF.sub.3                                                                          OMe                                           --     1 (trans)                                                                           K            OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           1/2Mg        OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           1/2Ca        OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           MeNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           EtNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           PrNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           Me           OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           Et           OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           .sup.i Pr    OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           Pr           OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           Bu           OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           .sup.i Bu    OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           .sup.s Bu    OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           .sup.t Bu    OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OCHF.sub.2                                                                          OMe                                           --     1 (trans)                                                                           H            OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           Li           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           Na           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           K            OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           1/2Mg        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           1/2Ca        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           MeNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           EtNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           PrNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           Me           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           Et           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           .sup.i Pr    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           Pr           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           Bu           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           .sup.i Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           .sup.s Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           .sup.t Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (trans)                                                                           H            SMe   OMe                                           --     1 (trans)                                                                           Li           SMe   OMe                                           --     1 (trans)                                                                           Na           SMe   OMe                                           --     1 (trans)                                                                           K            SMe   OMe                                           --     1 (trans)                                                                           1/2Mg        SMe   OMe                                           --     1 (trans)                                                                           1/2Ca        SMe   OMe                                           --     1 (trans)                                                                           MeNH.sub.3   SMe   OMe                                           --     1 (trans)                                                                           EtNH.sub.3   SMe   OMe                                           --     1 (trans)                                                                           PrNH.sub.3   SMe   OMe                                           --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          SMe   OMe                                           --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        SMe   OMe                                           --     1 (trans)                                                                           Me           SMe   OMe                                           --     1 (trans)                                                                           Et           SMe   OMe                                           --     1 (trans)                                                                           .sup.i Pr    SMe   OMe                                           --     1 (trans)                                                                           Pr           SMe   OMe                                           --     1 (trans)                                                                           Bu           SMe   OMe                                           --     1 (trans)                                                                           .sup.i Bu    SMe   OMe                                           --     1 (trans)                                                                           .sup.s Bu    SMe   OMe                                           --     1 (trans)                                                                           .sup.t Bu    SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        SMe   OMe                                           --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   OMe                                           --     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          SMe   OMe                                           --     1 (trans)                                                                           H            SMe   Me                                            --     1 (trans)                                                                           Li           SMe   Me                                            --     1 (trans)                                                                           Na           SMe   Me                                            --     1 (trans)                                                                           K            SMe   Me                                            --     1 (trans)                                                                           1/2Mg        SMe   Me                                            --     1 (trans)                                                                           1/2Ca        SMe   Me                                            --     1 (trans)                                                                           MeNH.sub.3   SMe   Me                                            --     1 (trans)                                                                           EtNH.sub.3   SMe   Me                                            --     1 (trans)                                                                           PrNH.sub.3   SMe   Me                                            --     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          SMe   Me                                            --     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        SMe   Me                                            --     1 (trans)                                                                           Me           SMe   Me                                            --     1 (trans)                                                                           Et           SMe   Me                                            --     1 (trans)                                                                           .sup.i Pr    SMe   Me                                            --     1 (trans)                                                                           Pr           SMe   Me                                            --     1 (trans)                                                                           Bu           SMe   Me                                            --     1 (trans)                                                                           .sup.i Bu    SMe   Me                                            --     1 (trans)                                                                           .sup.s Bu    SMe   Me                                            --     1 (trans)                                                                           .sup.t Bu    SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        SMe   Me                                            --     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                              SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   Me                                            --     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          SMe   Me                                            --     1 (mix.)                                                                            H            Me    Me                                            --     1 (mix.)                                                                            Li           Me    Me                                            --     1 (mix.)                                                                            Na           Me    Me                                            --     1 (mix.)                                                                            K            Me    Me                                            --     1 (mix.)                                                                            1/2 Mg       Me    Me                                            --     1 (mix.)                                                                            1/2 Ca       Me    Me                                            --     1 (mix.)                                                                            MeNH.sub.3   Me    Me                                            --     1 (mix.)                                                                            EtNH.sub.3   Me    Me                                            --     1 (mix.)                                                                            PrNH.sub.3   Me    Me                                            --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          Me    Me                                            --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        Me    Me                                            --     1 (mix.)                                                                            Me           Me    Me                                            --     1 (mix.)                                                                            Et           Me    Me                                            --     1 (mix.)                                                                            .sup.i Pr    Me    Me                                            --     1 (mix.)                                                                            Pr           Me    Me                                            --     1 (mix.)                                                                            Bu           Me    Me                                            --     1 (mix.)                                                                            .sup.i Bu    Me    Me                                            --     1 (mix.)                                                                            .sup.s Bu    Me    Me                                            --     1 (mix.)                                                                            .sup.t Bu    Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C CH.sub.2                                                                        Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                              Me    Me                                            --     1 (mix.)                                                                            CH.sub. 2 C.sub.6 H.sub.4 Cl-3                                                             Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Cl-4                                                              Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 OMe-2                                                             Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 OMe-3                                                             Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 OMe-4                                                             Me    Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            --     1 (mix.)                                                                            H            OMe   Me                                            --     1 (mix.)                                                                            Li           OMe   Me                                            --     1 (mix.)                                                                            Na           OMe   Me                                            --     1 (mix.)                                                                            K            OMe   Me                                            --     1 (mix.)                                                                            1/2 Mg       OMe   Me                                            --     1 (mix.)                                                                            1/2 Ca       OMe   Me                                            --     1 (mix.)                                                                            MeNH.sub.3   OMe   Me                                            --     1 (mix.)                                                                            EtNH.sub.3   OMe   Me                                            --     1 (mix.)                                                                            PrNH.sub.3   OMe   Me                                            --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          OMe   Me                                            --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        OMe   Me                                            --     1 (mix.)                                                                            Me           OMe   Me                                            --     1 (mix.)                                                                            Et           OMe   Me                                            --     1 (mix.)                                                                            .sup.i Pr    OMe   Me                                            --     1 (mix.)                                                                            Pr           OMe   Me                                            --     1 (mix.)                                                                            Bu           OMe   Me                                            --     1 (mix.)                                                                            .sup.i Bu    OMe   Me                                            --     1 (mix.)                                                                            .sup.s Bu    OMe   Me                                            --     1 (mix.)                                                                            .sup.t Bu    OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        OMe   Me                                            --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C CH.sub.2                                                                        OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                              OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Cl-3                                                              OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Cl-4                                                              OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 OMe-2                                                             OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 OMe-3                                                             OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 OMe-4                                                             OMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   Me                                            --     1 (mix.)                                                                            H            OMe   OMe                                           --     1 (mix.)                                                                            Li           OMe   OMe                                           --     1 (mix.)                                                                            Na           OMe   OMe                                           --     1 (mix.)                                                                            K            OMe   OMe                                           --     1 (mix.)                                                                            1/2 Mg       OMe   OMe                                           --     1 (mix.)                                                                            1/2 Ca       OMe   OMe                                           --     1 (mix.)                                                                            MeNH.sub.3   OMe   OMe                                           --     1 (mix.)                                                                            EtNH.sub.3   OMe   OMe                                           --     1 (mix.)                                                                            PrNH.sub.3   OMe   OMe                                           --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          OMe   OMe                                           --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           --     1 (mix.)                                                                            Me           OMe   OMe                                           --     1 (mix.)                                                                            Et           OMe   OMe                                           --     1 (mix.)                                                                            .sup.i Pr    OMe   OMe                                           --     1 (mix.)                                                                            Pr           OMe   OMe                                           --     1 (mix.)                                                                            Bu           OMe   OMe                                           --     1 (mix.)                                                                            .sup.i Bu    OMe   OMe                                           --     1 (mix.)                                                                            .sup.s Bu    OMe   OMe                                           --     1 (mix.)                                                                            .sup.t Bu    OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C CH.sub.2                                                                        OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                              OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub. 6 H.sub.4 Cl-3                                                             OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Cl-4                                                              OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           --     1 (miX.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           --     1 (mix.)                                                                            H            Cl    Me                                            --     1 (mix.)                                                                            Li           Cl    Me                                            --     1 (mix.)                                                                            Na           Cl    Me                                            --     1 (mix.)                                                                            K            Cl    Me                                            --     1 (mix.)                                                                            1/2 Mg       Cl    Me                                            --     1 (mix.)                                                                            1/2 Ca       Cl    Me                                            --     1 (mix.)                                                                            MeNH.sub.3   Cl    Me                                            --     1 (mix.)                                                                            EtNH.sub.3   Cl    Me                                            --     1 (mix.)                                                                            PrNH.sub.3   Cl    Me                                            --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          Cl    Me                                            --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        Cl    Me                                            --     1 (mix.)                                                                            Me           Cl    Me                                            --     1 (mix.)                                                                            Et           Cl    Me                                            --     1 (mix.)                                                                            .sup.i Pr    Cl    Me                                            --     1 (mix.)                                                                            Pr           Cl    Me                                            --     1 (mix.)                                                                            Bu           Cl    Me                                            --     1 (mix.)                                                                            .sup.i Bu    Cl    Me                                            --     1 (mix.)                                                                            .sup.s Bu    Cl    Me                                            --     1 (mix.)                                                                            .sup.t Bu    Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        Cl    Me                                            --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 CCH.sub.2                                                                         Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    Me                                            --     1 (mix.)                                                                            H            Cl    Cl                                            --     1 (mix.)                                                                            Li           Cl    Cl                                            --     1 (mix.)                                                                            Na           Cl    Cl                                            --     1 (mix.)                                                                            K            Cl    Cl                                            --     1 (mix.)                                                                            1/2 Mg       Cl    Cl                                            --     1 (mix.)                                                                            1/2 Ca       Cl    Cl                                            --     1 (mix.)                                                                            MeNH.sub.3   Cl    Cl                                            --     1 (mix.)                                                                            EtNH.sub.3   Cl    Cl                                            --     1 (mix.)                                                                            PrNH.sub.3   Cl    Cl                                            --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          Cl    Cl                                            --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        Cl    Cl                                            --     1 (mix.)                                                                            Me           Cl    Cl                                            --     1 (mix.)                                                                            Et           Cl    Cl                                            --     1 (mix.)                                                                            .sup.i Pr    Cl    Cl                                            --     1 (mix.)                                                                            Pr           Cl    Cl                                            --     1 (mix.)                                                                            Bu           Cl    Cl                                            --     1 (mix.)                                                                            .sup.i Bu    Cl    Cl                                            --     1 (mix.)                                                                            .sup.s Bu    Cl    Cl                                            --     1 (mix.)                                                                            .sup.t Bu    Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        Cl    Cl                                            --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 CCH.sub.2                                                                         Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Cl                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    Cl                                            --     1 (mix.)                                                                            H            Cl    OMe                                           --     1 (mix.)                                                                            Li           Cl    OMe                                           --     1 (mix.)                                                                            Na           Cl    OMe                                           --     1 (mix.)                                                                            K            Cl    OMe                                           --     1 (mix.)                                                                            1/2 Mg       Cl    OMe                                           --     1 (mix.)                                                                            1/2 Ca       Cl    OMe                                           --     1 (mix.)                                                                            MeNH.sub.3   Cl    OMe                                           --     1 (mix.)                                                                            EtNH.sub.3   Cl    OMe                                           --     1 (mix.)                                                                            PrNH.sub.3   Cl    OMe                                           --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          Cl    OMe                                           --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        Cl    OMe                                           --     1 (mix.)                                                                            Me           Cl    OMe                                           --     1 (mix.)                                                                            Et           Cl    OMe                                           --     1 (mix.)                                                                            .sup.i Pr    Cl    OMe                                           --     1 (mix.)                                                                            Pr           Cl    OMe                                           --     1 (mix.)                                                                            Bu           Cl    OMe                                           --     1 (mix.)                                                                            .sup.i Bu    Cl    OMe                                           --     1 (mix.)                                                                            .sup.s Bu    Cl    OMe                                           --     1 (mix.)                                                                            .sup.t Bu    Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        Cl    OMe                                           --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 CCH.sub.2                                                                         Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    OMe                                           --     1 (mix.)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                              Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    OMe                                           --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    OMe                                           --     1 (mix.)                                                                            H            OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            Li           OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            Na           OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            K            OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            1/2 Mg       OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            1/2 Ca       OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            MeNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            EtNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            PrNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        OCHF.sub.3                                                                          OMe                                           --     1 (mix.)                                                                            Me           OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            Et           OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            .sup.i Pr    OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            Pr           OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            Bu           OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            .sup.i Bu    OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            .sup.s Bu    OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            .sup.t Bu    OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 CCH.sub.2                                                                         OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OCHF.sub.2                                                                          OMe                                           --     1 (mix.)                                                                            H            OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            Li           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            Na           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            K            OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            1/2 Mg       OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            1/2 Ca       OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            MeNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            EtNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            PrNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            Me           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            Et           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            .sup.i Pr    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            Pr           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            Bu           OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            .sup.i Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            .sup.s Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            .sup.t Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C CH.sub.2                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OCHF.sub.2                                                                          OCHF.sub.2                                    --     1 (mix.)                                                                            H            SMe   OMe                                           --     1 (mix.)                                                                            Li           SMe   OMe                                           --     1 (mix.)                                                                            Na           SMe   OMe                                           --     1 (mix.)                                                                            K            SMe   OMe                                           --     1 (mix.)                                                                            1/2 Mg       SMe   OMe                                           --     1 (mix.)                                                                            1/2 Ca       SMe   OMe                                           --     1 (mix.)                                                                            MeNH.sub.3   SMe   OMe                                           --     1 (mix.)                                                                            EtNH.sub.3   SMe   OMe                                           --     1 (mix.)                                                                            PrNH.sub.3   SMe   OMe                                           --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          SMe   OMe                                           --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        SMe   OMe                                           --     1 (mix.)                                                                            Me           SMe   OMe                                           --     1 (mix.)                                                                            Et           SMe   OMe                                           --     1 (mix.)                                                                            .sup.i Pr    SMe   OMe                                           --     1 (mix.)                                                                            Pr           SMe   OMe                                           --     1 (mix.)                                                                            Bu           SMe   OMe                                           --     1 (mix.)                                                                            .sup.i Bu    SMe   OMe                                           --     1 (mix.)                                                                            .sup.s Bu    SMe   OMe                                           --     1 (mix.)                                                                            .sup.t Bu    SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        SMe   OMe                                           --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 CCH.sub.2                                                                         SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   OMe                                           --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          SMe   OMe                                           --     1 (mix.)                                                                            H            SMe   Me                                            --     1 (mix.)                                                                            Li           SMe   Me                                            --     1 (mix.)                                                                            Na           SMe   Me                                            --     1 (mix.)                                                                            K            SMe   Me                                            --     1 (mix.)                                                                            1/2 Mg       SMe   Me                                            --     1 (mix.)                                                                            1/2 Ca       SMe   Me                                            --     1 (mix.)                                                                            MeNH.sub.3   SMe   Me                                            --     1 (mix.)                                                                            EtNH.sub.3   SMe   Me                                            --     1 (mix.)                                                                            PrNH.sub.3   SMe   Me                                            --     1 (mix.)                                                                            .sup.i PrNH.sub.3                                                                          SMe   Me                                            --     1 (mix.)                                                                            NH.sub.2 CONH.sub.3                                                                        SMe   Me                                            --     1 (mix.)                                                                            Me           SMe   Me                                            --     1 (mix.)                                                                            Et           SMe   Me                                            --     1 (mix.)                                                                            .sup.i Pr    SMe   Me                                            --     1 (mix.)                                                                            Pr           SMe   Me                                            --     1 (mix.)                                                                            Bu           SMe   Me                                            --     1 (mix.)                                                                            .sup.i Bu    SMe   Me                                            --     1 (mix.)                                                                            .sup.s Bu    SMe   Me                                            --     1 (mix.)                                                                            .sup.t Bu    SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 OCH.sub.3                                                                         SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                                SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 SCH.sub.3                                                                         SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 CHCH.sub.2                                                                        SMe   Me                                            --     1 (mix.)                                                                            C(CH.sub.3).sub.2 CHCH.sub.2                                                               SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C CH.sub.2                                                                        SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   Me                                            --     1 (mix.)                                                                            CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          SMe   Me                                            --     2 (--)                                                                              H            Me    Me                                            --     2 (--)                                                                              Li           Me    Me                                            --     2 (--)                                                                              Na           Me    Me                                            --     2 (--)                                                                              K            Me    Me                                            --     2 (--)                                                                              1/2  Mg      Me    Me                                            --     2 (--)                                                                              1/2 Ca       Me    Me                                            --     2 (--)                                                                              MeNH.sub.3   Me    Me                                            --     2 (--)                                                                              EtNH.sub.3   Me    Me                                            --     2 (--)                                                                              PrNH.sub.3   Me    Me                                            --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            --     2 (--)                                                                              Me           Me    Me                                            --     2 (--)                                                                              Et           Me    Me                                            --     2 (--)                                                                              .sup.i Pr    Me    Me                                            --     2 (--)                                                                              Pr           Me    Me                                            --     2 (--)                                                                              Bu           Me    Me                                            --     2 (--)                                                                              .sup.i Bu    Me    Me                                            --     2 (--)                                                                              .sup.s Bu    Me    Me                                            --     2 (--)                                                                              .sup.t Bu    Me    Me                                            --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            --     2 (--)                                                                              H            OMe   Me                                            --     2 (-- )                                                                             Li           OMe   Me                                            --     2 (--)                                                                              Na           OMe   Me                                            --     2 (--)                                                                              K            OMe   Me                                            --     2 (--)                                                                              1/2 Mg       OMe   Me                                            --     2 (--)                                                                              1/2 Ca       OMe   Me                                            --     2 (--)                                                                              MeNH.sub.3   OMe   Me                                            --     2 (--)                                                                              EtNH.sub.3   OMe   Me                                            --     2 (--)                                                                              PrNH.sub.3   OMe   Me                                            --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   Me                                            --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   Me                                            --     2 (--)                                                                              Me           OMe   Me                                            --     2 (--)                                                                              Et           OMe   Me                                            --     2 (--)                                                                              .sup.i Pr    OMe   Me                                            --     2 (--)                                                                              Pr           OMe   Me                                            --     2 (--)                                                                              Bu           OMe   Me                                            --     2 (--)                                                                              .sup.i Bu    OMe   Me                                            --     2 (--)                                                                              .sup.s Bu    OMe   Me                                            --     2 (--)                                                                              .sup.t Bu    OMe   Me                                            --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   Me                                            --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   Me                                            --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   Me                                            --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   Me                                            --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   Me                                            --     2 (--)                                                                              H            OMe   OMe                                           --     2 (--)                                                                              Li           OMe   OMe                                           --     2 (--)                                                                              Na           OMe   OMe                                           --     2 (--)                                                                              K            OMe   OMe                                           --     2 (--)                                                                              1/2 Mg       OMe   OMe                                           --     2 (--)                                                                              1/2 Ca       OMe   OMe                                           --     2 (--)                                                                              MeNH.sub.3   OMe   OMe                                           --     2 (--)                                                                              EtNH.sub.3   OMe   OMe                                           --     2 (--)                                                                              PrNH.sub.3   OMe   OMe                                           --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           --     2 (--)                                                                              Me           OMe   OMe                                           --     2 (--)                                                                              Et           OMe   OMe                                            ##STR27##                                                                    --     2 (--)                                                                              .sup.i Pr    OMe   OMe                                           --     2 (--)                                                                              Pr           OMe   OMe                                           --     2 (--)                                                                              Bu           OMe   OMe                                           --     2 (--)                                                                              .sup.i Bu    OMe   OMe                                           --     2 (--)                                                                              .sup.s Bu    OMe   OMe                                           --     2 (--)                                                                              .sup.t Bu    OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           --     2 (--)                                                                              H            Cl    Me                                            --     2 (--)                                                                              Li           Cl    Me                                            --     2 (--)                                                                              Na           Cl    Me                                            --     2 (--)                                                                              K            Cl    Me                                            --     2 (--)                                                                              1/2 Mg       Cl    Me                                            --     2 (--)                                                                              1/2 Ca       Cl    Me                                            --     2 (--)                                                                              MeNH.sub.3   Cl    Me                                            --     2 (--)                                                                              EtNH.sub.3   Cl    Me                                            --     2 (--)                                                                              PrNH.sub.3   Cl    Me                                            --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Cl    Me                                            --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Cl    Me                                            --     2 (--)                                                                              Me           Cl    Me                                            --     2 (--)                                                                              Et           Cl    Me                                            --     2 (--)                                                                              .sup.i Pr    Cl    Me                                            --     2 (--)                                                                              Pr           Cl    Me                                            --     2 (--)                                                                              Bu           Cl    Me                                            --     2 (--)                                                                              .sup.i Bu    Cl    Me                                            --     2 (--)                                                                              .sup.s Bu    Cl    Me                                            --     2 (--)                                                                              .sup.t Bu    Cl    Me                                            --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Cl    Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Me                                            --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Cl    Me                                            --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Cl    Me                                            --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Me                                            --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Me                                            --     2 (-- )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    Me                                            --     2 (--)                                                                              H            Cl    Cl                                            --     2 (--)                                                                              Li           Cl    Cl                                            --     2 (--)                                                                              Na           Cl    Cl                                            --     2 (--)                                                                              K            Cl    Cl                                            --     2 (--)                                                                              1/2 Mg       Cl    Cl                                            --     2 (--)                                                                              1/2 Ca       Cl    Cl                                            --     2 (--)                                                                              MeNH.sub.3   Cl    Cl                                            --     2 (--)                                                                              EtNH.sub.3   Cl    Cl                                            --     2 (--)                                                                              PrNH.sub.3   Cl    Cl                                            --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Cl    Cl                                            --     2 (--)                                                                              NH.sub.2 CONH.sub. 3                                                                       Cl    Cl                                            --     2 (--)                                                                              Me           Cl    Cl                                            --     2 (--)                                                                              Et           Cl    Cl                                            --     2 (--)                                                                              .sup.i Pr    Cl    Cl                                            --     2 (--)                                                                              Pr           Cl    Cl                                            --     2 (--)                                                                              Bu           Cl    Cl                                            --     2 (--)                                                                              .sup.i Bu    Cl    Cl                                            --     2 (--)                                                                              .sup.s Bu    Cl    Cl                                            --     2 (--)                                                                              .sup.t Bu    Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Cl    Cl                                            --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    Cl                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    Cl                                            --     2 (--)                                                                              H            Cl    OMe                                           --     2 (--)                                                                              Li           Cl    OMe                                           --     2 (--)                                                                              Na           Cl    OMe                                           --     2 (--)                                                                              K            Cl    OMe                                           --     2 (--)                                                                              1/2 Mg       Cl    OMe                                           --     2 (--)                                                                              1/2 Ca       Cl    OMe                                           --     2 (--)                                                                              MeNH.sub.3   Cl    OMe                                           --     2 (--)                                                                              EtNH.sub.3   Cl    OMe                                           --     2 (--)                                                                              PrNH.sub.3   Cl    OMe                                           --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Cl    OMe                                           --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Cl    OMe                                           --     2 (--)                                                                              Me           Cl    OMe                                           --     2 (--)                                                                              Et           Cl    OMe                                           --     2 (--)                                                                              .sup.i Pr    Cl    OMe                                           --     2 (--)                                                                              Pr           Cl    OMe                                           --     2 (--)                                                                              Bu           Cl    OMe                                           --     2 (--)                                                                              .sup.i Bu    Cl    OMe                                           --     2 (--)                                                                              .sup.s Bu    Cl    OMe                                           --     2 (--)                                                                              .sup.t Bu    Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Cl    OMe                                           --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub. 5                                                                  Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Cl    OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Cl    OMe                                           --     2 (--)                                                                              H            OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              Li           OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              Na           OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              K            OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              1/2 Mg       OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              1/2 Ca       OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              MeNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              EtNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              PrNH.sub.3   OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              Me           OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              Et           OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              .sup.i Pr    OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              Pr           OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              Bu           OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              .sup.i Bu    OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              .sup.s Bu    OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              .sup.t Bu    OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OCHF.sub.2                                                                          OMe                                           --     2 (--)                                                                              H            OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              Li           OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              Na           OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              K            OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              1/2 Mg       OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              1/2 Ca       OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              MeNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              EtNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              PrNH.sub.3   OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              Me           OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              Et           OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              .sup.i Pr    OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              Pr           OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              Bu           OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              .sup.i Bu    OCHF.sub. 2                                                                         OCHF.sub.2                                    --     2 (--)                                                                              .sup.s Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              .sup.t Bu    OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                               CH.sub.2 C.sub.6 H.sub.4Me-2                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OCHF.sub.2                                                                          OCHF.sub.2                                    --     2 (--)                                                                              H            SMe   OMe                                           --     2 (--)                                                                              Li           SMe   OMe                                           --     2 (--)                                                                              Na           SMe   OMe                                           --     2 (--)                                                                              K            SMe   OMe                                           --     2 (--)                                                                              1/2 Mg       SMe   OMe                                           --     2 (--)                                                                              1/2 Ca       SMe   OMe                                           --     2 (--)                                                                              MeNH.sub.3   SMe   OMe                                           --     2 (--)                                                                              EtNH.sub.3   SMe   OMe                                           --     2 (--)                                                                              PrNH.sub.3   SMe   OMe                                           --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          SMe   OMe                                           --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        SMe   OMe                                           --     2 (--)                                                                              Me           SMe   OMe                                           --     2 (--)                                                                              Et           SMe   OMe                                           --     2 (--)                                                                              .sup.i Pr    SMe   OMe                                           --     2 (--)                                                                              Pr           SMe   OMe                                           --     2 (--)                                                                              Bu           SMe   OMe                                           --     2 (--)                                                                              .sup.i Bu    SMe   OMe                                           --     2 (--)                                                                              .sup.s Bu    SMe   OMe                                           --     2 (--)                                                                              .sup.t Bu    SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        SMe   OMe                                           --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub. 4Cl-2                                                              SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   OMe                                           --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          SMe   OMe                                           --     2 (--)                                                                              H            SMe   Me                                            --     2 (--)                                                                              Li           SMe   Me                                            --     2 (--)                                                                              Na           SMe   Me                                            --     2 (--)                                                                              K            SMe   Me                                            --     2 (--)                                                                              1/2Mg        SMe   Me                                            --     2 (--)                                                                              1/2Ca        SMe   Me                                            --     2 (--)                                                                              MeNH.sub.3   SMe   Me                                            --     2 (--)                                                                              EtNH.sub.3   SMe   Me                                            --     2 (--)                                                                              PrNH.sub.3   SMe   Me                                            --     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          SMe   Me                                            --     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        SMe   Me                                            --     2 (--)                                                                              Me           SMe   Me                                            --     2 (--)                                                                              Et           SMe   Me                                            --     2 (--)                                                                              .sup.i Pr    SMe   Me                                            --     2 (--)                                                                              Pr           SMe   Me                                            --     2 (--)                                                                              Bu           SMe   Me                                            --     2 (--)                                                                              .sup.i Bu    SMe   Me                                            --     2 (--)                                                                              .sup.s Bu    SMe   Me                                            --     2 (--)                                                                              .sup.t Bu    SMe   Me                                            --     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         SMe   Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                SMe   Me                                            --     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         SMe   Me                                            --     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        SMe   Me                                            --     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               SMe   Me                                            --     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Sme   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              SMe   Me                                            --     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              SMe   Me                                            --     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          SMe   Me                                            3-Me   1 (cis)                                                                             H            Me    Me                                            3-Me   1 (cis)                                                                             Na           Me    Me                                            3-Me   1 (cis)                                                                             1/2Ca        Me    Me                                            3-Me   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            3-Me   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3-Me   1 (cis)                                                                             Me           Me    Me                                            3-Me   1 (cis)                                                                             Et           Me    Me                                            3-Me   1 (cis)                                                                             .sup.i Pr    Me    Me                                            3-Me   1 (cis)                                                                             Pr           Me    Me                                            3-Me   1 (cis)                                                                             Bu           Me    Me                                            3-Me   1 (cis)                                                                             .sup.i Bu    Me    Me                                            3-Me   1 (cis)                                                                             .sup.s Bu    Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3-Me   1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3-Me   1 (cis)                                                                             H            OMe   OMe                                           3-Me   1 (cis)                                                                             Na           OMe   OMe                                           3-Me   1 (cis)                                                                             1/2Ca        OMe   OMe                                           3-Me   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me   1 (cis)                                                                             Me           OMe   OMe                                           3-Me   1 (cis)                                                                             Et           OMe   OMe                                           3-Me   1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           3-Me   1 (cis)                                                                             Pr           OMe   OMe                                           3-Me   1 (cis)                                                                             Bu           OMe   OMe                                           3-Me   1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           3-Me   1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3-Me   1 (cis)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                              OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3-Me   1 (trans)                                                                           H            Me    Me                                            3-Me   1 (trans)                                                                           Na           Me    Me                                            3-Me   1 (trans)                                                                           1/2Ca        Me    Me                                            3-Me   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            3-Me   1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3-Me   1 (trans)                                                                           Me           Me    Me                                            3-Me   1 (trans)                                                                           Et           Me    Me                                            3-Me   1 (trans)                                                                           .sup.i Pr    Me    Me                                            3-Me   1 (trans)                                                                           Pr           Me    Me                                            3-Me   1 (trans)                                                                           Bu           Me    Me                                            3-Me   1 (trans)                                                                           .sup.i Bu    Me    Me                                            3-Me   1 (trans)                                                                           .sup.s Bu    Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3-Me   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3-Me   1 (trans)                                                                           H            OMe   OMe                                           3-Me   1 (trans)                                                                           Na           OMe   OMe                                           3-Me   1 (trans)                                                                           1/2Ca        OMe   OMe                                           3-Me   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me   1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me   1 (trans)                                                                           Me           OMe   OMe                                           3-Me   1 (trans)                                                                           Et           OMe   OMe                                           3-Me   1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           3-Me   1 (trans)                                                                           Pr           OMe   OMe                                           3-Me   1 (trans)                                                                           Bu           OMe   OMe                                           3-Me   1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           3-Me   1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 CH CH.sub.2                                                                       OMe   OMe                                           3-Me   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3-Me   1 (mixt.)                                                                           H            Me    Me                                            3-Me   1 (mixt.)                                                                           Na           Me    Me                                            3-Me   1 (mixt.)                                                                           1/2Ca        Me    Me                                            3-Me   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            3-Me   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3-Me   1 (mixt.)                                                                           Me           Me    Me                                            3-Me   1 (mixt.)                                                                           Et           Me    Me                                            3-Me   1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            3-Me   1 (mixt.)                                                                           Pr           Me    Me                                            3-Me   1 (mixt.)                                                                           Bu           Me    Me                                            3-Me   1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            3-Me   1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3-Me   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3-Me   1 (mixt.)                                                                           H            OMe   OMe                                           3-Me   1 (mixt.)                                                                           Na           OMe   OMe                                           3-Me   1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           3-Me   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me   1 (mixt.)                                                                           Me           OMe   OMe                                           3-Me   1 (mixt.)                                                                           Et           OMe   OMe                                           3-Me   1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           3-Me   1 (mixt.)                                                                           Pr           OMe   OMe                                           3-Me   1 (mixt.)                                                                           Bu           OMe   OMe                                           3-Me   1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           3-Me   1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3-Me   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3-Me   2 (--)                                                                              H            Me    Me                                            3-Me   2 (--)                                                                              Na           Me    Me                                            3-Me   2 (--)                                                                              1/2Ca        Me    Me                                            3-Me   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            3-Me   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3-Me   2 (--)                                                                              Me           Me    Me                                            3-Me   2 (--)                                                                              Et           Me    Me                                            3-Me   2 (--)                                                                              .sup.i Pr    Me    Me                                            3-Me   2 (--)                                                                              Pr           Me    Me                                            3-Me   2 (--)                                                                              Bu           Me    Me                                            3-Me   2 (--)                                                                              .sup.i Bu    Me    Me                                            3-Me   2 (--)                                                                              .sup.s Bu    Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3-Me   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3-Me   2 (--)                                                                              CH.sub. 2 C.sub.6 H.sub.4Cl-3                                                              Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3-Me   2 (--)                                                                              H            OMe   OMe                                           3-Me   2 (--)                                                                              Na           OMe   OMe                                           3-Me   2 (--)                                                                              1/2Ca        OMe   OMe                                           3-Me   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me   2 (--)                                                                              Me           OMe   OMe                                           3-Me   2 (--)                                                                              Et           OMe   OMe                                           3-Me   2 (--)                                                                              .sup.i Pr    OMe   OMe                                           3-Me   2 (--)                                                                              Pr           OMe   OMe                                           3-Me   2 (--)                                                                              Bu           OMe   OMe                                           3-Me   2 (--)                                                                              .sup.i Bu    OMe   OMe                                           3-Me   2 (--)                                                                              .sup.s Bu    OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3-Me   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me   2 (-- )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Me   1 (cis)                                                                             H            Me    Me                                            4-Me   1 (cis)                                                                             Na           Me    Me                                            4-Me   1 (cis)                                                                             1/2Ca        Me    Me                                            4-Me   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Me   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Me   1 (cis)                                                                             Me           Me    Me                                            4-Me   1 (cis)                                                                             Et           Me    Me                                            4-Me   1 (cis)                                                                             .sup.i Pr    Me    Me                                            4-Me   1 (cis)                                                                             Pr           Me    Me                                            4-Me   1 (cis)                                                                             Bu           Me    Me                                            4-Me   1 (cis)                                                                             .sup.i Bu    Me    Me                                            4-Me   1 (cis)                                                                             .sup.s Bu    Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Me   1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-Me   1 (cis)                                                                             CH.sub. 2 CCH.sub.2                                                                        Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Me   1 (cis)                                                                             H            OMe   OMe                                           4-Me   1 (cis)                                                                             Na           OMe   OMe                                           4-Me   1 (cis)                                                                             1/2Ca        OMe   OMe                                           4-Me   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Me   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-Me   1 (cis)                                                                             Me           OMe   OMe                                           4-Me   1 (cis)                                                                             Et           OMe   OMe                                           4-Me   1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           4-Me   1 (cis)                                                                             Pr           OMe   OMe                                           4-Me   1 (cis)                                                                             Bu           OMe   OMe                                           4-Me   1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           4-Me   1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Me   1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-Me   1 (cis)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                              OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Me   1 (trans)                                                                           H            Me    Me                                            4-Me   1 (trans)                                                                           Na           Me    Me                                            4-Me   1 (trans)                                                                           1/2Ca        Me    Me                                            4-Me   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Me   1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Me   1 (trans)                                                                           Me           Me    Me                                            4-Me   1 (trans)                                                                           Et           Me    Me                                            4-Me   1 (trans)                                                                           .sup.i Pr    Me    Me                                            4-Me   1 (trans)                                                                           Pr           Me    Me                                            4-Me   1 (trans)                                                                           Bu           Me    Me                                            4-Me   1 (trans)                                                                           .sup.i Bu    Me    Me                                            4-Me   1 (trans)                                                                           .sup.s Bu    Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Me   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub. 2                                                              Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Me   1 (trans)                                                                           H            OMe   OMe                                           4-Me   1 (trans)                                                                           Na           OMe   OMe                                           4-Me   1 (trans)                                                                           1/2Ca        OMe   OMe                                           4-Me   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Me   1 (trans)                                                                           NH.sub.2 CONH.sub. 3                                                                       OMe   OMe                                           4-Me   1 (trans)                                                                           Me           OMe   OMe                                           4-Me   1 (trans)                                                                           Et           OMe   OMe                                           4-Me   1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           4-Me   1 (trans)                                                                           Pr           OMe   OMe                                           4-Me   1 (trans)                                                                           Bu           OMe   OMe                                           4-Me   1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           4-Me   1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Me   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub. 4Me-3                                                              OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Me   1 (mixt.)                                                                           H            Me    Me                                            4-Me   1 (mixt.)                                                                           Na           Me    Me                                            4-Me   1 (mixt.)                                                                           1/2Ca        Me    Me                                            4-Me   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Me   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Me   1 (mixt.)                                                                           Me           Me    Me                                            4-Me   1 (mixt.)                                                                           Et           Me    Me                                            4-Me   1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            4-Me   1 (mixt.)                                                                           Pr           Me    Me                                            4-Me   1 (mixt.)                                                                           Bu           Me    Me                                            4-Me   1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            4-Me   1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Me   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Me   1 (mixt.)                                                                           H            OMe   OMe                                           4-Me   1 (mixt.)                                                                           Na           OMe   OMe                                           4-Me   1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           4-Me   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Me   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-Me   1 (mixt.)                                                                           Me           OMe   OMe                                           4-Me   1 (mixt.)                                                                           Et           OMe   OMe                                           4-Me   1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           4-Me   1 (mixt.)                                                                           Pr           OMe   OMe                                           4-Me   1 (mixt.)                                                                           Bu           OMe   OMe                                           4-Me   1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           4-Me   1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Me   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Me   2 (--)                                                                              H            Me    Me                                            4-Me   2 (--)                                                                              Na           Me    Me                                            4-Me   2 (--)                                                                              1/2Ca        Me    Me                                            4-Me   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Me   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Me   2 (--)                                                                              Me           Me    Me                                            4-Me   2 (--)                                                                              Et           Me    Me                                            4-Me   2 (--)                                                                              .sup.i Pr    Me    Me                                            4-Me   2 (--)                                                                              Pr           Me    Me                                            4-Me   2 (--)                                                                              Bu           Me    Me                                            4-Me   2 (--)                                                                              .sup.i Bu    Me    Me                                            4-Me   2 (--)                                                                              .sup.s Bu    Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Me   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Me   2 (--)                                                                              H            OMe   OMe                                           4-Me   2 (--)                                                                              Na           OMe   OMe                                           4-Me   2 (--)                                                                              1/2Ca        OMe   OMe                                           4-Me   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Me   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-Me   2 (--)                                                                              Me           OMe   OMe                                           4-Me   2 (--)                                                                              Et           OMe   OMe                                           4-Me   2 (--)                                                                              .sup.i Pr    OMe   OMe                                           4-Me   2 (--)                                                                              Pr           OMe   OMe                                           4-Me   2 (--)                                                                              Bu           OMe   OMe                                           4-Me   2 (--)                                                                              .sup.i Bu    OMe   OMe                                           4-Me   2 (--)                                                                              .sup.s Bu    OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Me   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub. 5                                                                  OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-Me   1 (cis)                                                                             H            Me    Me                                            5-Me   1 (cis)                                                                             Na           Me    Me                                            5-Me   1 (cis)                                                                             1/2Ca        Me    Me                                            5-Me   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            5-Me   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-Me   1 (cis)                                                                             Me           Me    Me                                            5-Me   1 (cis)                                                                             Et           Me    Me                                            5-Me   1 (cis)                                                                             .sup.i Pr    Me    Me                                            5-Me   1 (cis)                                                                             Pr           Me    Me                                            5-Me   1 (cis)                                                                             Bu           Me    Me                                            5-Me   1 (cis)                                                                             .sup.i Bu    Me    Me                                            5-Me   1 (cis)                                                                             .sup.s Bu    Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-Me   1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5-Me   1 (cis)                                                                             CH.sub. 2 C.sub.6 H.sub.4OMe-2                                                             Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-Me   1 (cis)                                                                             H            OMe   OMe                                           5-Me   1 (cis)                                                                             Na           OMe   OMe                                           5-Me   1 (cis)                                                                             1/2Ca        OMe   OMe                                           5-Me   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5-Me   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-Me   1 (cis)                                                                             Me           OMe   OMe                                           5-Me   1 (cis)                                                                             Et           OMe   OMe                                           5-Me   1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           5-Me   1 (cis)                                                                             Pr           OMe   OMe                                           5-Me   1 (cis)                                                                             Bu           OMe   OMe                                           5-Me   1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           5-Me   1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-Me   1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C CH.sub.2                                                                        OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-Me   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-Me   1 (trans)                                                                           H            Me    Me                                            5-Me   1 (trans)                                                                           Na           Me    Me                                            5-Me   1 (trans)                                                                           1/2Ca        Me    Me                                            5-Me   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            5-Me   1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-Me   1 (trans)                                                                           Me           Me    Me                                            5-Me   1 (trans)                                                                           Et           Me    Me                                            5-Me   1 (trans)                                                                           .sup.i Pr    Me    Me                                            5-Me   1 (trans)                                                                           Pr           Me    Me                                            5-Me   1 (trans)                                                                           Bu           Me    Me                                            5-Me   1 (trans)                                                                           .sup.i Bu    Me    Me                                            5-Me   1 (trans)                                                                           .sup.s Bu    Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-Me   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-Me   1 (trans)                                                                           H            OMe   OMe                                           5-Me   1 (trans)                                                                           Na           OMe   OMe                                           5-Me   1 (trans)                                                                           1/2Ca        OMe   OMe                                           5-Me   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5-Me   1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-Me   1 (trans)                                                                           Me           OMe   OMe                                           5-Me   1 (trans)                                                                           Et           OMe   OMe                                           5-Me   1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           5-Me   1 (trans)                                                                           Pr           OMe   OMe                                           5-Me   1 (trans)                                                                           Bu           OMe   OMe                                           5-Me   1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           5-Me   1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-Me   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-Me   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-Me   1 (mixt.)                                                                           H            Me    Me                                            5-Me   1 (mixt.)                                                                           Na           Me    Me                                            5-Me   1 (mixt.)                                                                           1/2Ca        Me    Me                                            5-Me   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            5-Me   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-Me   1 (mixt.)                                                                           Me           Me    Me                                            5-Me   1 (mixt.)                                                                           Et           Me    Me                                            5-Me   1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            5-Me   1 (mixt.)                                                                           Pr           Me    Me                                            5-Me   1 (mixt.)                                                                           Bu           Me    Me                                            5-Me   1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            5-Me   1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-Me   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-Me   1 (mixt.)                                                                           H            OMe   OMe                                           5-Me   1 (mixt.)                                                                           Na           OMe   OMe                                           5-Me   1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           5-Me   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5-Me   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-Me   1 (mixt.)                                                                           Me           OMe   OMe                                           5-Me   1 (mixt.)                                                                           Et           OMe   OMe                                           5-Me   1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           5-Me   1 (mixt.)                                                                           Pr           OMe   OMe                                           5-Me   1 (mixt.)                                                                           Bu           OMe   OMe                                           5-Me   1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           5-Me   1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-Me   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-Me   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-Me   2 (--)                                                                              H            Me    Me                                            5-Me   2 (--)                                                                              Na           Me    Me                                            5-Me   2 (--)                                                                              1/2Ca        Me    Me                                            5-Me   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            5-Me   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-Me   2 (--)                                                                              Me           Me    Me                                            5-Me   2 (--)                                                                              Et           Me    Me                                            5-Me   2 (--)                                                                              .sup.i Pr    Me    Me                                            5-Me   2 (--)                                                                              Pr           Me    Me                                            5-Me   2 (--)                                                                              Bu           Me    Me                                            5-Me   2 (--)                                                                              .sup.i Bu    Me    Me                                            5-Me   2 (--)                                                                              .sup.s Bu    Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-Me   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-Me   2 (--)                                                                              H            OMe   OMe                                           5-Me   2 (--)                                                                              Na           OMe   OMe                                           5-Me   2 (--)                                                                              1/2Ca        OMe   OMe                                           5-Me   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   PMe                                           5-Me   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-Me   2 (--)                                                                              Me           OMe   OMe                                           5-Me   2 (--)                                                                              Et           OMe   OMe                                           5-Me   2 (--)                                                                              .sup.i Pr    OMe   OMe                                           5-Me   2 (--)                                                                              Pr           OMe   OMe                                           5-Me   2 (--)                                                                              Bu           OMe   OMe                                           5-Me   2 (--)                                                                              .sup.i Bu    OMe   OMe                                           5-Me   2 (--)                                                                              .sup.s Bu    OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-Me   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-Me   2 (--)                                                                               CH.sub.2 C.sub.6 H.sub.4OMe-3                                                             OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-Me   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             H            Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             Na           Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             Me           Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             Et           Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             Pr           Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             Bu           Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3.3-(Me).sub.2                                                                       1 (cis)                                                                             H            OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             Na           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub. 3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             Me           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             Et           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             Pr           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             Bu           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           H            Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           Na           Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           Me           Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           Et           Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           Pr           Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           Bu           Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub. 2 C.sub.6 H.sub.4OMe-3                                                             Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3.3-(Me).sub.2                                                                       1 (trans)                                                                           H            OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           Na           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           Me           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           Et           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           Pr           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           Bu           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                            CH.sub.2 CCH.sub.2                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           H            Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub. 4Cl-4                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           H            OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              H            Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              Na           Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              Me           Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              Et           Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              Pr           Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              Bu           Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            3.3-(Me).sub.2                                                                       2 (-- )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            3.3-(Me).sub.2                                                                       2 (--)                                                                              H            OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              Na           OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              Me           OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              Et           OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              Pr           OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              Bu           OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3.3-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             H            Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             Na           Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             Me           Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             Et           Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             Pr           Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             Bu           Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.4-(Me).sub.2                                                                       1 (cis)                                                                             H            OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             Na           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             Me           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             Et           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             Pr           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             Bu           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           H            Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           Na           Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           Me           Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           Et           Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           Pr           Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           Bu           Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C CH.sub.2                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.4-(Me).sub.2                                                                       1 (trans)                                                                           H            OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           Na           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           Me           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           Et           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           Pr           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           Bu           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub. 6 H.sub.4Me-2                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           H            Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub. 2                                                                      1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                             Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           H            OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub. 2                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              H            Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              Na           Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              Me           Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              Et           Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              Pr           Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              Bu           Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.4-(Me).sub.2                                                                       2 (--)                                                                              H            OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              Na           OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              Me           OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              Et           OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              Pr           OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              Bu           OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.4-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             H            Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             Na           Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             Me           Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             Et           Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             Pr           Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             Bu           Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5.5-(Me).sub. 2                                                                      1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5.5-(Me).sub.2                                                                       1 (cis)                                                                             H            OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             Na           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             Me           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             Et           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             Pr           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             Bu           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Ome   Ome                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub. 6 H.sub.5                                                                  OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           H            Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           Na           Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           Me           Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           Et           Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           Pr           Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           Bu           Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub. 2 C.sub.6 H.sub.4Me-3                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5.5-(Me).sub.2                                                                       1 (trans)                                                                           H            OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           Na           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           Me           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           Et           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           Pr           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           Bu           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           H            Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           H            OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              H            Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              Na           Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              Me           Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              Et           Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              Pr           Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              Bu           Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub. 2                                                                      2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub. 2 C.sub.6 H.sub.4OMe-3                                                             Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5.5-(Me).sub.2                                                                       2 (--)                                                                              H            OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              Na           OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              Me           OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              Et           OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              Pr           OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              Bu           OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5.5-(Me).sub. 2                                                                      2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             H            Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             Na           Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             Me           Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             Et           Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             Pr           Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             Bu           Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.5-(Me).sub.2                                                                       1 (cis)                                                                             H            OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             Na           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             1/2Ca        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             Me           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             Et           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             Pr           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             Bu           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           H            Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           Na           Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           Me           Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           Et           Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           Pr           Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           Bu           Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.5-(Me).sub.2                                                                       1 (trans)                                                                           H            OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           Na           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           1/2Ca        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           Me           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           Et           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           Pr           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           Bu           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           H            Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           H            OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Na           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Me           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Et           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Pr           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           Bu           OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH CH.sub.2                                                                       OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              H            Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              Na           Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              Me           Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              Et           Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              Pr           Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              Bu           Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4.5-(Me).sub.2                                                                       2 (--)                                                                              H            OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              Na           OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              1/2Ca        OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              Me           OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              Et           OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Pr    OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              Pr           OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              Bu           OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.i Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              .sup.s Bu    OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub. 2 C.sub.6 H.sub.4Cl-4                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4.5-(Me).sub.2                                                                       2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Et   1 (cis)                                                                             H            Me    Me                                            4-Et   1 (cis)                                                                             Na           Me    Me                                            4-Et   1 (cis)                                                                             1/2Ca        Me    Me                                            4-Et   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Et   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Et   1 (cis)                                                                             Me           Me    Me                                            4-Et   1 (cis)                                                                             Et           Me    Me                                            4-Et   1 (cis)                                                                             .sup.i Pr    Me    Me                                            4-Et   1 (cis)                                                                             Pr           Me    Me                                            4-Et   1 (cis)                                                                             Bu           Me    Me                                            4-Et   1 (cis)                                                                             .sup.i Bu    Me    Me                                            4-Et   1 (cis)                                                                             .sup.s Bu    Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Et   1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-4                                                             Me    Me                                            4-Et   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Et   1 (cis)                                                                             H            OMe   OMe                                           4-Et   1 (cis)                                                                             Na           OMe   OMe                                           4-Et   1 (cis)                                                                             1/2Ca        OMe   OMe                                           4-Et   1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Et   1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-Et   1 (cis)                                                                             Me           OMe   OMe                                           4-Et   1 (cis)                                                                             Et           OMe   OMe                                           4-Et   1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           4-Et   1 (cis)                                                                             Pr           OMe   OMe                                           4-Et   1 (cis)                                                                             Bu           OMe   OMe                                           4-Et   1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           4-Et   1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Et   1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Et   1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Et   1 (trans)                                                                           H            Me    Me                                            4-Et   1 (trans)                                                                           Na           Me    Me                                            4-Et   1 (trans)                                                                           1/2Ca        Me    Me                                            4-Et   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Et   1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Et   1 (trans)                                                                           Me           Me    Me                                            4-Et   1 (trans)                                                                           Et           Me    Me                                            4-Et   1 (trans)                                                                           .sup.i Pr    Me    Me                                            4-Et   1 (trans)                                                                           Pr           Me    Me                                            4-Et   1 (trans)                                                                           Bu           Me    Me                                            4-Et   1 (trans)                                                                           .sup.i Bu    Me    Me                                            4-Et   1 (trans)                                                                           .sup.s Bu    Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Et   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Et   1 (trans)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-4                                                             Me    Me                                            4-Et   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Et   1 (trans)                                                                           H            OMe   OMe                                           4-Et   1 (trans)                                                                           Na           OMe   OMe                                           4-Et   1 (trans)                                                                           1/2Ca        OMe   OMe                                           4-Et   1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Et   1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-Et   1 (trans)                                                                           Me           OMe   OMe                                           4-Et   1 (trans)                                                                           Et           OMe   OMe                                           4-Et   1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           4-Et   1 (trans)                                                                           Pr           OMe   OMe                                           4-Et   1 (trans)                                                                           Bu           OMe   OMe                                           4-Et   1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           4-Et   1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Et   1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub. 2 C.sub.6 H.sub.4Cl-2                                                              OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Et   1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Et   1 (mixt.)                                                                           H            Me    Me                                            4-Et   1 (mixt.)                                                                           Na           Me    Me                                            4-Et   1 (mixt.)                                                                           1/2Ca        Me    Me                                            4-Et   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Et   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Et   1 (mixt.)                                                                           Me           Me    Me                                            4-Et   1 (mixt.)                                                                           Et           Me    Me                                            4-Et   1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            4-Et   1 (mixt.)                                                                           Pr           Me    Me                                            4-Et   1 (mixt.)                                                                           Bu           Me    Me                                            4-Et   1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            4-Et   1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Et   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-Et   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Et   1 (mixt.)                                                                           H            OMe   OMe                                           4-Et   1 (mixt.)                                                                           Na           OMe   OMe                                           4-Et   1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           4-Et   1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Et   1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-Et   1 (mixt.)                                                                           Me           OMe   OMe                                           4-Et   1 (mixt.)                                                                           Et           OMe   OMe                                           4-Et   1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           4-Et   1 (mixt.)                                                                           Pr           OMe   OMe                                           4-Et   1 (mixt.)                                                                           Bu           OMe   OMe                                           4-Et   1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           4-Et   1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Et   1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Et   1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-Et   2 (--)                                                                              H            Me    Me                                            4-Et   2 (--)                                                                              Na           Me    Me                                            4-Et   2 (--)                                                                              1/2Ca        Me    Me                                            4-Et   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            4-Et   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-Et   2 (--)                                                                              Me           Me    Me                                            4-Et   2 (--)                                                                              Et           Me    Me                                            4-Et   2 (--)                                                                              .sup.i Pr    Me    Me                                            4-Et   2 (-- )                                                                             Pr           Me    Me                                            4-Et   2 (--)                                                                              Bu           Me    Me                                            4-Et   2 (--)                                                                              .sup.i Bu    Me    Me                                            4-Et   2 (--)                                                                              .sup.s Bu    Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-Et   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-Et   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-Et   2 (--)                                                                              H            OMe   OMe                                           4-Et   2 (--)                                                                              Na           OMe   OMe                                           4-Et   2 (--)                                                                              1/2Ca        OMe   OMe                                           4-Et   2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-Et   2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-Et   2 (--)                                                                              Me           OMe   OMe                                           4-Et   2 (--)                                                                              Et           OMe   OMe                                           4-Et   2 (--)                                                                              .sup.i Pr    OMe   OMe                                           4-Et   2 (--)                                                                              Pr           OMe   OMe                                           4-Et   2 (--)                                                                              Bu           OMe   OMe                                           4-Et   2 (--)                                                                              .sup.i Bu    OMe   OMe                                           4-Et   2 (--)                                                                              .sup.s Bu    OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-Et   2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-Et   2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             H            Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             Na           Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             1/2Ca        Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             Me           Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             Et           Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.i Pr    Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             Pr           Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             Bu           Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.i Bu    Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.s Bu    Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C CH.sub.2                                                                        Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.i Pr                                                                          1 (cis)                                                                             H            OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             Na           OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             1/2Ca        OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             Me           OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             Et           OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             Pr           OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             Bu           OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           H            Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           Na           Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           1/2Ca        Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           Me           Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           Et           Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.i Pr    Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           Pr           Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           Bu           Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.i Bu    Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.s Bu    Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub. 6 H.sub.5                                                                  Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.i Pr                                                                          1 (trans)                                                                           H            OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           Na           OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           1/2Ca        OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           Me           OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           Et           OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           Pr           OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           Bu           OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           H            Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           Na           Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           1/2Ca        Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           Me           Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           Et           Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           Pr           Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           Bu           Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.i Pr                                                                          1 (mixt.)                                                                           H            OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           Na           OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           Me           OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           Et           OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           Pr           OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           Bu           OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.i Pr                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              H            Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              Na           Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              1/2Ca        Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              Me           Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              Et           Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              .sup.i Pr    Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              Pr           Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              Bu           Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              .sup.i Bu    Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              .sup.s Bu    Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.i Pr                                                                          2 (-- )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.i Pr                                                                          2 (--)                                                                              H            OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              Na           OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              1/2Ca        OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              Me           OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              Et           OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              .sup.i Pr    OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              Pr           OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              Bu           OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              .sup.i Bu    OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              .sup.s Bu    OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.i Pr                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             H            Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             Na           Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             1/2Ca        Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             Me           Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             Et           Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i Pr    Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             Pr           Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             Bu           Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i Bu    Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.s Bu    Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.t Bt                                                                          1 (cis)                                                                             H            OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             Na           OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             1/2Ca        OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             Me           OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             Et           OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             Bt           OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             Bu           OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.t  Bt                                                                         1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           H            Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           Na           Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           1/2Ca        Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           Me           Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           Et           Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i Pr    Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           Pr           Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           Bu           Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i Bu    Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           .sup.s Bu    Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4 Me-2                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.t Bt                                                                          1 (trans)                                                                           H            OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           Na           OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           1/2Ca        OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           Me           OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           Et           OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           Pr           OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           Bu           OMe   OMe                                           4-.sup. t Bt                                                                         1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                            CH.sub.2 C.sub.6 H.sub.4Me-3                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           H            Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           Na           Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           1/2Ca        Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           Me           Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           Et           Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           Pr           Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           Bu           Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            4-.sup. t Bt                                                                         1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.t Bt                                                                          1 (mixt.)                                                                           H            OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           Na           OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           Me           OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           Et           OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           Pr           OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           Bu           OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              H            Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              Na           Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              1/2Ca        Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              Me           Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              Et           Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Pr    Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              Bt           Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              Bu           Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Bu    Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              .sup.s Bu    Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4 Me-3                                                              Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            4-.sup.t Bt                                                                          2 (--)                                                                              H            OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              Na           OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              1/2Ca        OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              Me           OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              Et           OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Pr    OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              Pr           OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              Bu           OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Bu    OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              .sup.s Bu    OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           4-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             H            Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             Na           Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             1/2Ca        Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             Me           Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             Et           Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i Pr    Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             Pr           Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             Bu           Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i Bu    Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             .sup.s Bu    Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-.sup.t Bt                                                                          1 (cis)                                                                             H            OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             Na           OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             1/2Ca        OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             Me           OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             Et           OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             Pr           OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             Bu           OMe   OMe                                           5-.sup.t  Bt                                                                         1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           H            Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           Na           Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           1/2Ca        Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           Me           Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           Et           Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i Pr    Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           Pr           Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           Bu           Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i Bu    Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.s Bu    Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-.sup.t  Bt                                                                         1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-.sup.t Bt                                                                          1 (trans)                                                                           H            OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           Na           OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           1/2Ca        OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           Me           OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           Et           OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           Pr           OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           Bu           OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           5-.sup. t Bt                                                                         1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4 Me-4                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           H            Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           Na           Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           1/2Ca        Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           Me           Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           Et           Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Pr    Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           Pr           Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           Bu           Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Bu    Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.s Bu    Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                            CH.sub.2 C.sub.6 H.sub.4OMe-2                                                             Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-.sup.t Bt                                                                          1 (mixt.)                                                                           H            OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           Na           OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           Me           OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           Et           OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           Pr           OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           Bu           OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub. 2 CH.sub.2 OCH.sub.3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-.sup. t Bt                                                                         1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-.sup.t Bt                                                                          1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              H            Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              Na           Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              1/2Ca        Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              .sup.i PrNH.sub.3                                                                          Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              Me           Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              Et           Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Pr    Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              Pr           Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              Bu           Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Bu    Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              .sup.s Bu    Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          Me    Me                                            5-.sup.t Bt                                                                          2 (--)                                                                              H            OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              Na           OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              1/2Ca        OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              Me           OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              Et           OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Pr    OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              Pr           OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              Bu           OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              .sup.i Bu    OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              .sup.s Bu    OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           5-.sup.t Bt                                                                          2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             H            OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             Na           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             1/2Ca        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             Me           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             Et           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             Pr           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             Bu           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           H            OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           Na           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           1/2Ca        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           Me           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           Et           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           Pr           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           Bu           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                            CH.sub.2 CHCH.sub.2                                                                       OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           H            OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           Na           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           Me           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           Et           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           Pr           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           Bu           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C CH.sub.2                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              H            OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              Na           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              1/2Ca        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              Me           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              Et           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              .sup.i Pr    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              Pr           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              Bu           OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              .sup.i Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              .sup.s Bu    OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3-Me-6-.sup.i Pr                                                                     2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             H            OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             Na           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             1/2Ca        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             Me           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             Et           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             .sup.i Pr    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             Pr           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             Bu           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             .sup.i Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             .sup.s Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub. 4Cl-2                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (cis)                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           H            OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           Na           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           1/2Ca        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           Me           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           Et           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           .sup.i Pr    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           Pr           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           Bu           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           .sup.i Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           .sup.s Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (trans)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           H            OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           Na           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           1/2Ca        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           Me           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           Et           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           .sup.i Pr    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           Pr           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           Bu           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           .sup.i Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           .sup.s Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    1 (mixt.)                                                                           CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              H            OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              Na           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              1/2Ca        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              .sup.i PrNH.sub.3                                                                          OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              NH.sub.2 CONH.sub.3                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              Me           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              Et           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              .sup.i Pr    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              Pr           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              Bu           OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              .sup.i Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              .sup.s Bu    OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 OCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 SCH.sub.3                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 CHCH.sub.2                                                                        OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 CCH.sub.2                                                                         OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                   OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (-- )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                               OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                              OMe   OMe                                           3- .sup.i Pr-6-Me                                                                    2 (--)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                          OMe   OMe                                           __________________________________________________________________________

                  TABLE 3                                                         ______________________________________                                        A compound of the general formula:                                             ##STR28##                                                                    In the below-mentioned table, Me represents methyl                            group, Et represents ethyl group, Pr represents propyl                        group, .sup.i Pr represents isopropyl group, Bu represents butyl              group, .sup.i Bu represents isobutyl group, .sup.s Bu represents              secondary butyl group, .sup.t Bu represents tertiary butyl                    group, cis represents a cis-form, trans represents a                          trans-form, mix. represents a mixture of a cis-form and                       a trans-form, 1 represents a single bond and 2 represents                     a double bond                                                                 (X).sub.m       R              R.sup.1                                                                              R.sup.2                                 ______________________________________                                        --     1 (cis)  H              Me     Me                                      --     1 (cis)  Li             Me     Me                                      --     1 (cis)  Na             Me     Me                                      --     1 (cis)  K              Me     Me                                      --     1 (cis)  1/2Mg          Me     Me                                      --     1 (cis)  1/2Ca          Me     Me                                      --     1 (cis)  MeNH.sub.3     Me     Me                                      --     1 (cis)  EtNH.sub.3     Me     Me                                      --     1 (cis)  PrNH.sub.3     Me     Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            Me     Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     1 (cis)  Me             Me     Me                                      --     1 (cis)  Et             Me     Me                                      --     1 (cis)  .sup.i Pr      Me     Me                                      --     1 (cis)  Pr             Me     Me                                      --     1 (cis)  Bu             Me     Me                                      --     1 (cis)  .sup.i Bu      Me     Me                                      --     1 (cis)  .sup.s Bu      Me     Me                                      --     1 (cis)  .sup.t Bu      Me     Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     1 (cis)  H              OMe    Me                                      --     1 (cis)  Li             OMe    Me                                      --     1 (cis)  Na             OMe    Me                                      --     1 (cis)  K              OMe    Me                                      --     1 (cis)  1/2Mg          OMe    Me                                      --     1 (cis)  1/2Ca          OMe    Me                                      --     1 (cis)  MeNH.sub.3     OMe    Me                                      --     1 (cis)  EtNH.sub.3     OMe    Me                                      --     1 (cis)  PrNH.sub.3     OMe    Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     1 (cis)  Me             OMe    Me                                      --     1 (cis)  Et             OMe    Me                                      --     1 (cis)  .sup.i Pr      OMe    Me                                      --     1 (cis)  Pr             OMe    Me                                      --     1 (cis)  Bu             OMe    Me                                      --     1 (cis)  .sup.i Bu      OMe    Me                                      --     1 (cis)  .sup.s Bu      OMe    Me                                      --     1 (cis)  .sup.t Bu      OMe    Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub. 5                                                                    OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     1 (cis)  H              OMe    OMe                                     --     1 (cis)  Li             OMe    OMe                                     --     1 (cis)  Na             OMe    OMe                                     --     1 (cis)  K              OMe    OMe                                     --     1 (cis)  1/2Mg          OMe    OMe                                     --     1 (cis)  1/2Ca          OMe    OMe                                     --     1 (cis)  MeNH.sub.3     OMe    OMe                                     --     1 (cis)  EtNH.sub.3     OMe    OMe                                     --     1 (cis)  PrNH.sub.3     OMe    OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     --     1 (cis)  Me             OMe    OMe                                     --     1 (cis)  Et             OMe    OMe                                     --     1 (cis)  .sup.i Pr      OMe    OMe                                     --     1 (cis)  Pr             OMe    OMe                                     --     1 (cis)  Bu             OMe    OMe                                     --     1 (cis)  .sup.i Bu      OMe    OMe                                     --     1 (cis)  .sup.s Bu      OMe    OMe                                     --     1 (cis)  .sup.t Bu      OMe    OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     1 (cis)  H              Cl     Me                                      --     1 (cis)  Li             Cl     Me                                      --     1 (cis)  Na             Cl     Me                                      --     1 (cis)  K              Cl     Me                                      --     1 (cis)  1/2Mg          Cl     Me                                      --     1 (cis)  1/2Ca          Cl     Me                                      --     1 (cis)  MeNH.sub.3     Cl     Me                                      --     1 (cis)  EtNH.sub.3     Cl     Me                                      --     1 (cis)  PrNH.sub.3     Cl     Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Cl     Me                                      --     1 (cis)  Me             Cl     Me                                      --     1 (cis)  Et             Cl     Me                                      --     1 (cis)  .sup.i Pr      Cl     Me                                      --     1 (cis)  Pr             Cl     Me                                      --     1 (cis)  Bu             Cl     Me                                      --     1 (cis)  .sup.i Bu      Cl     Me                                      --     1 (cis)  .sup.s Bu      Cl     Me                                      --     1 (cis)  .sup.t Bu      Cl     Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Cl     Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Me                                      --     1 (cis)  H              Cl     Cl                                      --     1 (cis)  Li             Cl     Cl                                      --     1 (cis)  Na             Cl     Cl                                      --     1 (cis)  K              Cl     Cl                                      --     1 (cis)  1/2Mg          Cl     Cl                                      --     1 (cis)  1/2Ca          Cl     Cl                                      --     1 (cis)  MeNH.sub.3     Cl     Cl                                      --     1 (cis)  EtNH.sub.3     Cl     Cl                                      --     1 (cis)  PrNH.sub.3     Cl     Cl                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            Cl     Cl                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     1 (cis)  Me             Cl     Cl                                      --     1 (cis)  Et             Cl     Cl                                      --     1 (cis)  .sup.i Pr      Cl     Cl                                      --     1 (cis)  Pr             Cl     Cl                                      --     1 (cis)  Bu             Cl     Cl                                      --     1 (cis)  .sup.i Bu      Cl     Cl                                      --     1 (cis)  .sup.s Bu      Cl     Cl                                      --     1 (cis)  .sup.t Bu      Cl     Cl                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Cl     Cl                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Cl                                      --     1 (cis)  H              Cl     OMe                                     --     1 (cis)  Li             Cl     OMe                                     --     1 (cis)  Na             Cl     OMe                                     --     1 (cis)  K              Cl     OMe                                     --     1 (cis)  1/2Mg          Cl     OMe                                     --     1 (cis)  1/2Ca          Cl     OMe                                     --     1 (cis)  MeNH.sub.3     Cl     OMe                                     --     1 (cis)  EtNH.sub.3     Cl     OMe                                     --     1 (cis)  PrNH.sub.3     Cl     OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     1 (cis)  Me             Cl     OMe                                     --     1 (cis)  Et             Cl     OMe                                     --     1 (cis)  .sup.i Pr      Cl     OMe                                     --     1 (cis)  Pr             Cl     OMe                                     --     1 (cis)  Bu             Cl     OMe                                     --     1 (cis)  .sup.i Bu      Cl     OMe                                     --     1 (cis)  .sup.s Bu      Cl     OMe                                     --     1 (cis)  .sup.t Bu      Cl     OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     1 (cis)  H              OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Li             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Na             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  K              OCHF.sub.2                                                                           OMe                                     --     1 (cis)  1/2Mg          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  1/2Ca          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Me             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Et             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Pr             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  Bu             OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.i Bu      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     1 (cis)  H              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  K              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CCH.sub. 2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (cis)  H              SMe    OMe                                     --     1 (cis)  Li             SMe    OMe                                     --     1 (cis)  Na             SMe    OMe                                     --     1 (cis)  K              SMe    OMe                                     --     1 (cis)  1/2Mg          SMe    OMe                                     --     1 (cis)  1/2Ca          SMe    OMe                                     --     1 (cis)  MeNH.sub.3     SMe    OMe                                     --     1 (cis)  EtNH.sub.3     SMe    OMe                                     --     1 (cis)  PrNH.sub.3     SMe    OMe                                     --     1 (cis)  .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     1 (cis)  Me             SMe    OMe                                     --     1 (cis)  Et             SMe    OMe                                     --     1 (cis)  .sup.i Pr      SMe    OMe                                     --     1 (cis)  Pr             SMe    OMe                                     --     1 (cis)  Bu             SMe    OMe                                     --     1 (cis)  .sup.i Bu      SMe    OMe                                     --     1 (cis)  .sup.s Bu      SMe    OMe                                     --     1 (cis)  .sup.t Bu      SMe    OMe                                     --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     1 (cis)  CH.sub. 2 CCH.sub.2                                                                          SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    OMe                                     --     1 (cis)  H              SMe    Me                                      --     1 (cis)  Li             SMe    Me                                      --     1 (cis)  Na             SMe    Me                                      --     1 (cis)  K              SMe    Me                                      --     1 (cis)  1/2Mg          SMe    Me                                      --     1 (cis)  1/2Ca          SMe    Me                                      --     1 (cis)  MeNH.sub.3     SMe    Me                                      --     1 (cis)  EtNH.sub.3     SMe    Me                                      --     1 (cis)  PrNH.sub.3     SMe    Me                                      --     1 (cis)  .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     1 (cis)  NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     1 (cis)  Me             SMe    Me                                      --     1 (cis)  Et             SMe    Me                                      --     1 (cis)  .sup.i Pr      SMe    Me                                      --     1 (cis)  Pr             SMe    Me                                      --     1 (cis)  Bu             SMe    Me                                      --     1 (cis)  .sup.i Bu      SMe    Me                                      --     1 (cis)  .sup.s Bu      SMe    Me                                      --     1 (cis)  .sup.t Bu      SMe    Me                                      --     1 (cis)  CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     1 (cis)  CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     1 (cis)  CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 CCH.sub. 2                                                                          SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      --     1 (trans)                                                                              H              Me     Me                                      --     1 (trans)                                                                              Li             Me     Me                                      --     1 (trans)                                                                              Na             Me     Me                                      --     1 (trans)                                                                              K              Me     Me                                      --     1 (trans)                                                                              1/2Mg          Me     Me                                      --     1 (trans)                                                                              1/2Ca          Me     Me                                      --     1 (trans)                                                                              MeNH.sub.3     Me     Me                                      --     1 (trans)                                                                              EtNH.sub.3     Me     Me                                      --     1 (trans)                                                                              PrNH.sub.3     Me     Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Me     Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     1 (trans)                                                                              Me             Me     Me                                      --     1 (trans)                                                                              Et             Me     Me                                      --     1 (trans)                                                                              .sup.i Pr      Me     Me                                      --     1 (trans)                                                                              Pr             Me     Me                                      --     1 (trans)                                                                              Bu             Me     Me                                      --     1 (trans)                                                                              .sup.i Bu      Me     Me                                      --     1 (trans)                                                                              .sup.s Bu      Me     Me                                      --     1 (trans)                                                                              .sup.t Bu      Me     Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     1 (trans)                                                                              H              OMe    Me                                      --     1 (trans)                                                                              Li             OMe    Me                                      --     1 (trans)                                                                              Na             OMe    Me                                      --     1 (trans)                                                                              K              OMe    Me                                      --     1 (trans)                                                                              1/2Mg          OMe    Me                                      --     1 (trans)                                                                              1/2Ca          OMe    Me                                      --     1 (trans)                                                                              MeNH.sub.3     OMe    Me                                      --     1 (trans)                                                                              EtNH.sub.3     OMe    Me                                      --     1 (trans)                                                                              PrNH.sub.3     OMe    Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     1 (trans)                                                                              Me             OMe    Me                                      --     1 (trans)                                                                              Et             OMe    Me                                      --     1 (trans)                                                                              .sup.i Pr      OMe    Me                                      --     1 (trans)                                                                              Pr             OMe    Me                                      --     1 (trans)                                                                              Bu             OMe    Me                                      --     1 (trans)                                                                              .sup.i Bu      OMe    Me                                      --     1 (trans)                                                                              .sup.s Bu      OMe    Me                                      --     1 (trans)                                                                              .sup.t Bu      OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub. 6 H.sub.4Cl-2                                                                OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     1 (trans)                                                                              H              OMe    OMe                                     --     1 (trans)                                                                              Li             OMe    OMe                                     --     1 (trans)                                                                              Na             OMe    OMe                                     --     1 (trans)                                                                              K              OMe    OMe                                     --     1 (trans)                                                                              1/2Mg          OMe    OMe                                     --     1 (trans)                                                                              1/2Ca          OMe    OMe                                     --     1 (trans)                                                                              MeNH.sub.3     OMe    OMe                                     --     1 (trans)                                                                              EtNH.sub.3     OMe    OMe                                     --     1 (trans)                                                                              PrNH.sub.3     OMe    OMe                                     --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     --     1 (trans)                                                                              Me             OMe    Ome                                     --     1 (trans)                                                                              Et             OMe    OMe                                     --     1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     --     1 (trans)                                                                              Pr             OMe    OMe                                     --     1 (trans)                                                                              Bu             OMe    OMe                                     --     1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     --     1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     --     1 (trans)                                                                              .sup.t Bu      OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub. 2 C.sub.6 H.sub.4Cl-3                                                                OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     1 (trans)                                                                              H              Cl     Me                                      --     1 (trans)                                                                              Li             Cl     Me                                      --     1 (trans)                                                                              Na             Cl     Me                                      --     1 (trans)                                                                              K              Cl     Me                                      --     1 (trans)                                                                              1/2Mg          Cl     Me                                      --     1 (trans)                                                                              1/2Ca          Cl     Me                                      --     1 (trans)                                                                              MeNH.sub.3     Cl     Me                                      --     1 (trans)                                                                              EtNH.sub.3     Cl     Me                                      --     1 (trans)                                                                              PrNH.sub.3     Cl     Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Cl     Me                                      --     1 (trans)                                                                              Me             Cl     Me                                      --     1 (trans)                                                                              Et             Cl     Me                                      --     1 (trans)                                                                              .sup.i Pr      Cl     Me                                      --     1 (trans)                                                                              Pr             Cl     Me                                      --     1 (trans)                                                                              Bu             Cl     Me                                      --     1 (trans)                                                                              .sup.i Bu      Cl     Me                                      --     1 (trans)                                                                              .sup.s Bu      Cl     Me                                      --     1 (trans)                                                                              .sup.t Bu      Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Cl     Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Me                                      --     1 (trans)                                                                              H              Cl     Cl                                      --     1 (trans)                                                                              Li             Cl     Cl                                      --     1 (trans)                                                                              Na             Cl     Cl                                      --     1 (trans)                                                                              K              Cl     Cl                                      --     1 (trans)                                                                              1/2Mg          Cl     Cl                                      --     1 (trans)                                                                              1/2Ca          Cl     Cl                                      --     1 (trans)                                                                              MeNH.sub.3     Cl     Cl                                      --     1 (trans)                                                                              EtNH.sub.3     Cl     Cl                                      --     1 (trans)                                                                              PrNH.sub.3     Cl     Cl                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Cl     Cl                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     1 (trans)                                                                              Me             Cl     Cl                                      --     1 (trans)                                                                              Et             Cl     Cl                                      --     1 (trans)                                                                              .sup.i Pr      Cl     Cl                                      --     1 (trans)                                                                              Pr             Cl     Cl                                      --     1 (trans)                                                                              Bu             Cl     Cl                                      --     1 (trans)                                                                              .sup.i Bu      Cl     Cl                                      --     1 (trans)                                                                              .sup.s Bu      Cl     Cl                                      --     1 (trans)                                                                              .sup.t Bu      Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Cl                                      --     1 (trans)                                                                              H              Cl     OMe                                     --     1 (trans)                                                                              Li             Cl     OMe                                     --     1 (trans)                                                                              Na             Cl     OMe                                     --     1 (trans)                                                                              K              Cl     OMe                                     --     1 (trans)                                                                              1/2Mg          Cl     OMe                                     --     1 (trans)                                                                              1/2Ca          Cl     OMe                                     --     1 (trans)                                                                              MeNH.sub.3     Cl     OMe                                     --     1 (trans)                                                                              EtNH.sub.3     Cl     OMe                                     --     1 (trans)                                                                              PrNH.sub.3     Cl     OMe                                     --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     1 (trans)                                                                              Me             Cl     OMe                                     --     1 (trans)                                                                              Et             Cl     OMe                                     --     1 (trans)                                                                              .sup.i Pr      Cl     OMe                                     --     1 (trans)                                                                              Pr             Cl     OMe                                     --     1 (trans)                                                                              Bu             Cl     OMe                                     --     1 (trans)                                                                              .sup.i Bu      Cl     OMe                                     --     1 (trans)                                                                              .sup.s Bu      Cl     OMe                                     --     1 (trans)                                                                              .sup.t Bu      Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     1 (trans)                                                                              H              OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Li             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Na             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              K              OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              1/2Mg          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              1/2Ca          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Me             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Et             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Pr             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              Bu             OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.i Bu      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     1 (trans)                                                                              H              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              K              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup. i PrNH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (trans)                                                                              H              SMe    OMe                                     --     1 (trans)                                                                              Li             SMe    OMe                                     --     1 (trans)                                                                              Na             SMe    OMe                                     --     1 (trans)                                                                              K              SMe    OMe                                     --     1 (trans)                                                                              1/2Mg          SMe    OMe                                     --     1 (trans)                                                                              1/2Ca          SMe    OMe                                     --     1 (trans)                                                                              MeNH.sub.3     SMe    OMe                                     --     1 (trans)                                                                              EtNH.sub.3     SMe    OMe                                     --     1 (trans)                                                                              PrNH.sub.3     SMe    OMe                                     --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     1 (trans)                                                                              Me             SMe    OMe                                     --     1 (trans)                                                                              Et             SMe    OMe                                     --     1 (trans)                                                                              .sup.i Pr      SMe    OMe                                     --     1 (trans)                                                                              Pr             SMe    OMe                                     --     1 (trans)                                                                              Bu             SMe    OMe                                     --     1 (trans)                                                                              .sup.i Bu      SMe    OMe                                     --     1 (trans)                                                                              .sup.s Bu      SMe    OMe                                     --     1 (trans)                                                                              .sup.t Bu      SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CCH.sub. 2                                                                          SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     1 (trans)                                                                              CH.sub.2 CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                   SMe    OMe                                     --     1 (trans)                                                                              H              SMe    Me                                      --     1 (trans)                                                                              Li             SMe    Me                                      --     1 (trans)                                                                              Na             SMe    Me                                      --     1 (trans)                                                                              K              SMe    Me                                      --     1 (trans)                                                                              1/2Mg          SMe    Me                                      --     1 (trans)                                                                              1/2 Ca         SMe    Me                                      --     1 (trans)                                                                              MeNH.sub.3     SMe    Me                                      --     1 (trans)                                                                              EtNH.sub.3     SMe    Me                                      --     1 (trans)                                                                              PrNH.sub.3     SMe    Me                                      --     1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     1 (trans)                                                                              Me             SMe    Me                                      --     1 (trans)                                                                              Et             SMe    Me                                      --     1 (trans)                                                                              .sup.i Pr      SMe    Me                                      --     1 (trans)                                                                              Pr             SMe    Me                                      --     1 (trans)                                                                              Bu             SMe    Me                                      --     1 (trans)                                                                              .sup.i Bu      SMe    Me                                      --     1 (trans)                                                                              .sup.s Bu      SMe    Me                                      --     1 (trans)                                                                              .sup.t Bu      SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      --     1 (mixt. )                                                                             H              Me     Me                                      --     1 (mixt. )                                                                             Li             Me     Me                                      --     1 (mixt. )                                                                             Na             Me     Me                                      --     1 (mixt. )                                                                             K              Me     Me                                      --     1 (mixt. )                                                                             1/2Mg          Me     Me                                      --     1 (mixt. )                                                                             1/2Ca          Me     Me                                      --     1 (mixt. )                                                                             MeNH.sub.3     Me     Me                                      --     1 (mixt. )                                                                             EtNH.sub.3     Me     Me                                      --     1 (mixt. )                                                                             PrNH.sub.3     Me     Me                                      --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            Me     Me                                      --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     1 (mixt. )                                                                             Me             Me     Me                                      --     1 (mixt. )                                                                             Et             Me     Me                                      --     1 (mixt. )                                                                             .sup.i Pr      Me     Me                                      --     1 (mixt. )                                                                             Pr             Me     Me                                      --     1 (mixt. )                                                                             Bu             Me     Me                                      --     1 (mixt. )                                                                             .sup.i Bu      Me     Me                                      --     1 (mixt. )                                                                             .sup.s Bu      Me     Me                                      --     1 (mixt. )                                                                             .sup.t Bu      Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C CH.sub.2                                                                          Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     1 (mixt. )                                                                             H              OMe    Me                                      --     1 (mixt. )                                                                             Li             OMe    Me                                      --     1 (mixt. )                                                                             Na             OMe    Me                                      --     1 (mixt. )                                                                             K              OMe    Me                                      --     1 (mixt. )                                                                             1/2Mg          OMe    Me                                      --     1 (mixt. )                                                                             1/2Ca          OMe    Me                                      --     1 (mixt. )                                                                             MeNH.sub.3     OMe    Me                                      --     1 (mixt. )                                                                             EtNH.sub.3     OMe    Me                                      --     1 (mixt. )                                                                             PrNH.sub.3     OMe    Me                                      --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            OMe    Me                                      --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     1 (mixt. )                                                                             Me             OMe    Me                                      --     1 (mixt. )                                                                             Et             OMe    Me                                      --     1 (mixt. )                                                                             .sup.i Pr      OMe    Me                                      --     1 (mixt. )                                                                             Pr             OMe    Me                                      --     1 (mixt. )                                                                             Bu             OMe    Me                                      --     1 (mixt. )                                                                             .sup.i Bu      OMe    Me                                      --     1 (mixt. )                                                                             .sup.s Bu      OMe    Me                                      --     1 (mixt. )                                                                             .sup.t Bu      OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     1 (mixt. )                                                                             C(CH.sub. 3).sub.2 CHCH.sub.2                                                                OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     1 (mixt. )                                                                             H              OMe    OMe                                     --     1 (mixt. )                                                                             Li             OMe    OMe                                     --     1 (mixt. )                                                                             Na             OMe    OMe                                     --     1 (mixt. )                                                                             K              OMe    OMe                                     --     1 (mixt. )                                                                             1/2Mg          OMe    OMe                                     --     1 (mixt. )                                                                             1/2Ca          OMe    OMe                                     --     1 (mixt. )                                                                             MeNH.sub.3     OMe    OMe                                     --     1 (mixt. )                                                                             EtNH.sub.3     OMe    OMe                                     --     1 (mixt. )                                                                             PrNH.sub.3     OMe    OMe                                     --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            OMe    OMe                                     --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     --     1 (mixt. )                                                                             Me             OMe    OMe                                     --     1 (mixt. )                                                                             Et             OMe    OMe                                     --     1 (mixt. )                                                                             .sup.i Pr      OMe    OMe                                     --     1 (mixt. )                                                                             Pr             OMe    OMe                                     --     1 (mixt. )                                                                             Bu             OMe    OMe                                     --     1 (mixt. )                                                                             .sup.i Bu      OMe    OMe                                     --     1 (mixt. )                                                                             .sup.s Bu      OMe    OMe                                     --     1 (mixt. )                                                                             .sup.t Bu      OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4 OMe-4                                                               OMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     1 (mixt. )                                                                             H              Cl     Me                                      --     1 (mixt. )                                                                             Li             Cl     Me                                      --     1 (mixt. )                                                                             Na             Cl     Me                                      --     1 (mixt. )                                                                             K              Cl     Me                                      --     1 (mixt. )                                                                             1/2Mg          Cl     Me                                      --     1 (mixt. )                                                                             1/2Ca          Cl     Me                                      --     1 (mixt. )                                                                             MeNH.sub.3     Cl     Me                                      --     1 (mixt. )                                                                             EtNH.sub.3     Cl     Me                                      --     1 (mixt. )                                                                             PrNH.sub.3     Cl     Me                                      --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          Cl     Me                                      --     1 (mixt. )                                                                             Me             Cl     Me                                      --     1 (mixt. )                                                                             Et             Cl     Me                                      --     1 (mixt. )                                                                             .sup.i Pr      Cl     Me                                      --     1 (mixt. )                                                                             Pr             Cl     Me                                      --     1 (mixt. )                                                                             Bu             Cl     Me                                      --     1 (mixt. )                                                                             .sup.i Bu      Cl     Me                                      --     1 (mixt. )                                                                             .sup.s Bu      Cl     Me                                      --     1 (mixt. )                                                                             .sup.t Bu      Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                           --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Me                                      --     1 (mixt. )                                                                             H              Cl     Cl                                      --     1 (mixt. )                                                                             Li             Cl     Cl                                      --     1 (mixt. )                                                                             Na             Cl     Cl                                      --     1 (mixt. )                                                                             K              Cl     Cl                                      --     1 (mixt. )                                                                             1/2Mg          Cl     Cl                                      --     1 (mixt. )                                                                             1/2Ca          Cl     Cl                                      --     1 (mixt. )                                                                             MeNH.sub.3     Cl     Cl                                      --     1 (mixt. )                                                                             EtNH.sub.3     Cl     Cl                                      --     1 (mixt. )                                                                             PrNH.sub.3     Cl     Cl                                      --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            Cl     Cl                                      --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     1 (mixt. )                                                                             Me             Cl     Cl                                      --     1 (mixt. )                                                                             Et             Cl     Cl                                      --     1 (mixt. )                                                                             .sup.i Pr      Cl     Cl                                      --     1 (mixt. )                                                                             Pr             Cl     Cl                                      --     1 (mixt. )                                                                             Bu             Cl     Cl                                      --     1 (mixt. )                                                                             .sup.i Bu      Cl     Cl                                      --     1 (mixt. )                                                                             .sup.s Bu      Cl     Cl                                      --     1 (mixt. )                                                                             .sup.t Bu      Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub. 4Me-4                                                                Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     Cl                                      --     1 (mixt. )                                                                             H              Cl     OMe                                     --     1 (mixt. )                                                                             Li             Cl     OMe                                     --     1 (mixt. )                                                                             Na             Cl     OMe                                     --     1 (mixt. )                                                                             K              Cl     OMe                                     --     1 (mixt. )                                                                             1/2Mg          Cl     OMe                                     --     1 (mixt. )                                                                             1/2Ca          Cl     OMe                                     --     1 (mixt. )                                                                             MeNH.sub.3     Cl     OMe                                     --     1 (mixt. )                                                                             EtNH.sub.3     Cl     OMe                                     --     1 (mixt. )                                                                             PrNH.sub.3     Cl     OMe                                     --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     1 (mixt. )                                                                             Me             Cl     OMe                                     --     1 (mixt. )                                                                             Et             Cl     OMe                                     --     1 (mixt. )                                                                             .sup.i Pr      Cl     OMe                                     --     1 (mixt. )                                                                             Pr             Cl     OMe                                     --     1 (mixt. )                                                                             Bu             Cl     OMe                                     --     1 (mixt. )                                                                             .sup.i Bu      Cl     OMe                                     --     1 (mixt. )                                                                             .sup.s Bu      Cl     OMe                                     --     1 (mixt. )                                                                             .sup.t Bu      Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     1 (mixt. )                                                                             H              OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             Li             OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             Na             OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             K              OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             1/2Mg          OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             1/2Ca          OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             Me             OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             Et             OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             Pr             OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             Bu             OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             .sup.i Bu      OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                                OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     1 (mixt. )                                                                             H              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             K              OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub. 2                             --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     1 (mixt. )                                                                             H              SMe    OMe                                     --     1 (mixt. )                                                                             Li             SMe    OMe                                     --     1 (mixt. )                                                                             Na             SMe    OMe                                     --     1 (mixt. )                                                                             K              SMe    OMe                                     --     1 (mixt. )                                                                             1/2Mg          SMe    OMe                                     --     1 (mixt. )                                                                             1/2Ca          SMe    OMe                                     --     1 (mixt. )                                                                             MeNH.sub.3     SMe    OMe                                     --     1 (mixt. )                                                                             EtNH.sub.3     SMe    OMe                                     --     1 (mixt. )                                                                             PrNH.sub.3     SMe    OMe                                     --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     1 (mixt. )                                                                             Me             SMe    OMe                                     --     1 (mixt. )                                                                             Et             SMe    OMe                                     --     1 (mixt. )                                                                             .sup.i Pr      SMe    OMe                                     --     1 (mixt. )                                                                             Pr             SMe    OMe                                     --     1 (mixt. )                                                                             Bu             SMe    OMe                                     --     1 (mixt. )                                                                             .sup.i Bu      SMe    OMe                                     --     1 (mixt. )                                                                             .sup.s Bu      SMe    OMe                                     --     1 (mixt. )                                                                             .sup.t Bu      SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    OMe                                     --     1 (mixt. )                                                                             H              SMe    Me                                      --     1 (mixt. )                                                                             Li             SMe    Me                                      --     1 (mixt. )                                                                             Na             SMe    Me                                      --     1 (mixt. )                                                                             K              SMe    Me                                      --     1 (mixt. )                                                                             1/2Mg          SMe    Me                                      --     1 (mixt. )                                                                             1/2Ca          SMe    Me                                      --     1 (mixt. )                                                                             MeNH.sub.3     SMe    Me                                      --     1 (mixt. )                                                                             EtNH.sub.3     SMe    Me                                      --     1 (mixt. )                                                                             PrNH.sub.3     SMe    Me                                      --     1 (mixt. )                                                                             .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     1 (mixt. )                                                                             NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     1 (mixt. )                                                                             Me             SMe    Me                                      --     1 (mixt. )                                                                             Et             SMe    Me                                      --     1 (mixt. )                                                                             .sup.i Pr      SMe    Me                                      --     1 (mixt. )                                                                             Pr             SMe    Me                                      --     1 (mixt. )                                                                             Bu             SMe    Me                                      --     1 (mixt. )                                                                             .sup.i Bu      SMe    Me                                      --     1 (mixt. )                                                                             .sup.s Bu      SMe    Me                                      --     1 (mixt. )                                                                             .sup.t Bu      SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     1 (mixt. )                                                                             C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CCH.sub.2                                                                           SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     1 (mixt. )                                                                             CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      --     2 (--)   H              Me     Me                                      --     2 (--)   Li             Me     Me                                      --     2 (--)   Na             Me     Me                                      --     2 (--)   K              Me     Me                                      --     2 (--)   1/2Mg          Me     Me                                      --     2 (--)   1/2Ca          Me     Me                                      --     2 (--)   MeNH.sub.3     Me     Me                                      --     2 (--)   EtNH.sub.3     Me     Me                                      --     2 (--)   PrNH.sub.3     Me     Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            Me     Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Me     Me                                      --     2 (--)   Me             Me     Me                                      --     2 (--)   Et             Me     Me                                      --     2 (--)   .sup.i Pr      Me     Me                                      --     2 (--)   Pr             Me     Me                                      --     2 (--)   Bu             Me     Me                                      --     2 (--)   .sup.i Bu      Me     Me                                      --     2 (--)   .sup.s Bu      Me     Me                                      --     2 (--)   .sup.t Bu      Me     Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           Me     Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Me     Me                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           Me     Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Me     Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Me     Me                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Me     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Me     Me                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Me     Me                                      --     2 (--)   H              OMe    Me                                      --     2 (--)   Li             OMe    Me                                      --     2 (--)   Na             OMe    Me                                      --     2 (--)   K              OMe    Me                                      --     2 (--)   1/2Mg          OMe    Me                                      --     2 (--)   1/2Ca          OMe    Me                                      --     2 (--)   MeNH.sub.3     OMe    Me                                      --     2 (--)   EtNH.sub.3     OMe    Me                                      --     2 (--)   PrNH.sub.3     OMe    Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            OMe    Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    Me                                      --     2 (--)   Me             OMe    Me                                      --     2 (--)   Et             OMe    Me                                      --     2 (--)   .sup.i Pr      OMe    Me                                      --     2 (--)   Pr             OMe    Me                                      --     2 (--)   Bu             OMe    Me                                      --     2 (--)   .sup.i Bu      OMe    Me                                      --     2 (--)   .sup.s Bu      OMe    Me                                      --     2 (--)   .sup.t Bu      OMe    Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    Me                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub. 4Cl-2                                                                OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    Me                                      --     2 (--)   H              OMe    OMe                                     --     2 (--)   Li             OMe    OMe                                     --     2 (--)   Na             OMe    OMe                                     --     2 (--)   K              OMe    OMe                                     --     2 (--)   1/2Mg          OMe    OMe                                     --     2 (--)   1/2Ca          OMe    OMe                                     --     2 (--)   MeNH.sub.3     OMe    OMe                                     --     2 (--)   EtNH.sub.3     OMe    OMe                                     --     2 (--)   PrNH.sub.3     OMe    OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     --     2 (--)   Me             OMe    OMe                                     --     2 (--)   Et             OMe    OMe                                     --     2 (--)   .sup.i Pr      OMe    OMe                                     --     2 (--)   Pr             OMe    OMe                                     --     2 (--)   Bu             OMe    OMe                                     --     2 (--)   .sup.i Bu      OMe    OMe                                     --     2 (--)   .sup.s Bu      OMe    OMe                                     --     2 (--)   .sup.t Bu      OMe    OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     --     2 (--)   H              Cl     Me                                      --     2 (--)   Li             Cl     Me                                      --     2 (--)   Na             Cl     Me                                      --     2 (--)   K              Cl     Me                                      --     2 (-- )  1/2Mg          Cl     Me                                      --     2 (--)   1/2Ca          Cl     Me                                      --     2 (--)   MeNH.sub.3     Cl     Me                                      --     2 (--)   EtNH.sub.3     Cl     Me                                      --     2 (--)   PrNH.sub.3     Cl     Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            Cl     Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Cl     Me                                      --     2 (--)   Me             Cl     Me                                      --     2 (--)   Et             Cl     Me                                      --     2 (--)   .sup.i Pr      Cl     Me                                      --     2 (--)   Pr             Cl     Me                                      --     2 (--)   Bu             Cl     Me                                      --     2 (--)   .sup.i Bu      Cl     Me                                      --     2 (--)   .sup.s Bu      Cl     Me                                      --     2 (--)   .sup.t Bu      Cl     Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           Cl     Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Me                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           Cl     Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Cl     Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Me                                      --     2 (--)   H              Cl     Cl                                      --     2 (--)   Li             Cl     Cl                                      --     2 (--)   Na             Cl     Cl                                      --     2 (--)   K              Cl     Cl                                      --     2 (--)   1/2Mg          Cl     Cl                                      --     2 (--)   1/2Ca          Cl     Cl                                      --     2 (--)   MeNH.sub.3     Cl     Cl                                      --     2 (--)   EtNH.sub.3     Cl     Cl                                      --     2 (--)   PrNH.sub.3     Cl     Cl                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            Cl     Cl                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Cl     Cl                                      --     2 (--)   Me             Cl     Cl                                      --     2 (--)   Et             Cl     Cl                                      --     2 (--)   .sup.i Pr      Cl     Cl                                      --     2 (--)   Pr             Cl     Cl                                      --     2 (--)   Bu             Cl     Cl                                      --     2 (--)   .sup.i Bu      Cl     Cl                                      --     2 (--)   .sup.s Bu      Cl     Cl                                      --     2 (--)   .sup.t Bu      Cl     Cl                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           Cl     Cl                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     Cl                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           Cl     Cl                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Cl     Cl                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                Cl     Cl                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     Cl                                      --     2 (--)    CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                           Cl     Cl                                      --     2 (--)   H              Cl     OMe                                     --     2 (--)   Li             Cl     OMe                                     --     2 (--)   Na             Cl     OMe                                     --     2 (--)   K              Cl     OMe                                     --     2 (--)   1/2Mg          Cl     OMe                                     --     2 (--)   1/2Ca          Cl     OMe                                     --     2 (--)   MeNH.sub.3     Cl     OMe                                     --     2 (--)   EtNH.sub.3     Cl     OMe                                     --     2 (--)   PrNH.sub.3     Cl     OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            Cl     OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          Cl     OMe                                     --     2 (--)   Me             Cl     OMe                                     --     2 (--)   Et             Cl     OMe                                     --     2 (--)   .sup.i Pr      Cl     OMe                                     --     2 (--)   Pr             Cl     OMe                                     --     2 (--)   Bu             Cl     OMe                                     --     2 (--)   .sup.i Bu      Cl     OMe                                     --     2 (--)   .sup.s Bu      Cl     OMe                                     --     2 (--)   .sup.t Bu      Cl     OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           Cl     OMe                                     --     2 (--)   CH.sub. 2 CH.sub.2 OCH.sub.3                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           Cl     OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          Cl     OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4 OMe-3                                                               Cl     OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                Cl     OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            Cl     OMe                                     --     2 (--)   H              OCHF.sub.2                                                                           OMe                                     --     2 (--)   Li             OCHF.sub.2                                                                           OMe                                     --     2 (--)   Na             OCHF.sub.2                                                                           OMe                                     --     2 (--)   K              OCHF.sub.2                                                                           OMe                                     --     2 (--)   1/2Mg          OCHF.sub.2                                                                           OMe                                     --     2 (--)   1/2Ca          OCHF.sub.2                                                                           OMe                                     --     2 (--)   MeNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     2 (--)   EtNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     2 (--)   PrNH.sub.3     OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OMe                                     --     2 (--)   Me             OCHF.sub.2                                                                           OMe                                     --     2 (--)   Et             OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.i Pr      OCHF.sub.2                                                                           OMe                                     --     2 (--)   Pr             OCHF.sub.2                                                                           OMe                                     --     2 (--)   Bu             OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.i Bu      OCHF.sub. 2                                                                          OMe                                     --     2 (--)   .sup.s Bu      OCHF.sub.2                                                                           OMe                                     --     2 (--)   .sup.t Bu      OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OMe                                     --     2 (--)   H              OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Li             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Na             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   K              OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   1/2Mg          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   1/2Ca          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   MeNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   EtNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   PrNH.sub.3     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.i PrNH.sub.3                                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   NH.sub.2 CONH.sub.3                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Me             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Et             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.i Pr      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Pr             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   Bu             OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.i Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.s Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   .sup.t Bu      OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 OCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 SCH.sub.3                                                                           OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CCH.sub.2                                                                           OCHF.sub. 2                                                                          OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OCHF.sub.2                                                                           OCHF.sub.2                              --     2 (--)   H              SMe    OMe                                     --     2 (--)   Li             SMe    OMe                                     --     2 (--)   Na             SMe    OMe                                     --     2 (--)   K              SMe    OMe                                     --     2 (--)   1/2Mg          SMe    OMe                                     --     2 (--)   1/2Ca          SMe    OMe                                     --     2 (--)   MeNH.sub.3     SMe    OMe                                     --     2 (--)   EtNH.sub.3     SMe    OMe                                     --     2 (--)   PrNH.sub.3     SMe    OMe                                     --     2 (--)   .sup.i PrNH.sub.3                                                                            SMe    OMe                                     --     2 (--)   NH.sub.2 CONH.sub.3                                                                          SMe    OMe                                     --     2 (--)   Me             SMe    OMe                                     --     2 (--)   Et             SMe    OMe                                     --     2 (--)   .sup.i Pr      SMe    OMe                                     --     2 (--)   Pr             SMe    OMe                                     --     2 (--)   Bu             SMe    OMe                                     --     2 (--)   .sup.i Bu      SMe    OMe                                     --     2 (--)   .sup.s Bu      SMe    OMe                                     --     2 (--)   .sup.t Bu      SMe    OMe                                     --     2 (--)   CH.sub.2 OCH.sub.3                                                                           SMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    OMe                                     --     2 (--)   CH.sub.2 SCH.sub.3                                                                           SMe    OMe                                     --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          SMe    OMe                                     --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 CCH.sub.2                                                                           SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    OMe                                     --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    OMe                                     --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    OMe                                     --     2 (--)   H              SMe    Me                                      --     2 (--)   Li             SMe    Me                                      --     2 (--)   Na             SMe    Me                                      --     2 (--)   K              SMe    Me                                      --     2 (--)   1/2Mg          SMe    Me                                      --     2 (--)   1/2Ca          SMe    Me                                      --     2 (--)   MeNH.sub.3     SMe    Me                                      --     2 (--)   EtNH.sub.3     SMe    Me                                      --     2 (--)   PrNH.sub.3     SMe    Me                                      --     2 (--)   .sup.i PrNH.sub.3                                                                            SMe    Me                                      --     2 (--)   NH.sub.2 CONH.sub.3                                                                          SMe    Me                                      --     2 (--)   Me             SMe    Me                                      --     2 (--)   Et             SMe    Me                                      --     2 (--)   .sup.i Pr      SMe    Me                                      --     2 (--)   Pr             SMe    Me                                      --     2 (--)   Bu             SMe    Me                                      --     2 (--)   .sup.i Bu      SMe    Me                                      --     2 (--)   .sup.s Bu      SMe    Me                                      --     2 (--)   .sup.t Bu      SMe    Me                                      --     2 (--)   CH.sub.2 OCH.sub.3                                                                           SMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  SMe    Me                                      --     2 (--)   CH.sub.2 SCH.sub.3                                                                           SMe    Me                                      --     2 (--)   CH.sub.2 CHCH.sub.2                                                                          SMe    Me                                      --     2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 CCH.sub.2                                                                           SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                SMe    Me                                      --     2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                SMe    Me                                      --     2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            SMe    Me                                      5.5-(Me).sub.2                                                                       1 (cis)  H              OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  Na             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  1/2Ca          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  Me             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  Et             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  .sup.i Pr      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  Pr             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  Bu             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  .sup.i Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  .sup.s Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              H              OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              Na             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              1/2Ca          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i PrNH.sub. 3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              Me             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              Et             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              Pr             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              Bu             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              H              OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              Na             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              1/2Ca          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              Me             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              Et             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.i Pr      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              Pr             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              Bu             OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.i Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.s Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub. 2 C.sub.6 H.sub.4OMe-3                                                               OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   H              OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   Na             OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   1/2Ca          OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   Me             OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   Et             OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   .sup.i Pr      OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   Pr             OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   Bu             OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   .sup.i Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   .sup.s Bu      OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     5.5-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.7-(Me).sub. 2                                                                      1 (cis)  H              OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  Na             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  1/2Ca          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  Me             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  Et             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  .sup.i Pr      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  Pr             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  Bu             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  .sup.i Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  .sup.s Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (cis)  CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              H              OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              Na             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              1/2Ca          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              Me             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              Et             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Pr      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              Pr             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              Bu             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              .sup.i Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              .sup.s Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub. 2 C.sub.6 H.sub.4Me-4                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (trans)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              H              OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              Na             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              1/2Ca          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              Me             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              Et             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.i Pr      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              Pr             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              Bu             OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.i Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              .sup.s Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       1 (mixt.)                                                                              CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   H              OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   Na             OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   1/2Ca          OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   .sup.i PrNH.sub.3                                                                            OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   NH.sub.2 CONH.sub.3                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   Me             OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   Et             OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   .sup.i Pr      OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   Pr             OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   Bu             OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   .sup.i Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   .sup.s Bu      OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 OCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 SCH.sub.3                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 CHCH.sub.2                                                                          OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 CCH.sub.2                                                                           OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.5                                                                     OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                 OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                OMe    OMe                                     3.7-(Me).sub.2                                                                       2 (--)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                            OMe    OMe                                     ______________________________________                                    

                  TABLE 4                                                         ______________________________________                                        A compound of the general formula:                                             ##STR29##                                                                    ______________________________________                                        H                   cis    (+)                                                H                   cis    (-)                                                H                   trans  (+)                                                H                   trans  (-)                                                Li                  cis    (+)                                                Li                  cis    (-)                                                Li                  trans  (+)                                                Li                  trans  (-)                                                Na                  cis    (+)                                                Na                  cis    (-)                                                Na                  trans  (+)                                                Na                  trans  (-)                                                K                   cis    (+)                                                K                   cis    (-)                                                K                   trans  (+)                                                K                   trans  (-)                                                1/2Mg               cis    (+)                                                1/2Mg               cis    (-)                                                1/2Mg               trans  (+)                                                1/2Mg               trans  (-)                                                NH.sub.4            cis    (±)                                             NH.sub.4            cis    (+)                                                NH.sub.4            cis    (-)                                                NH.sub.4            mixt.                                                     NH.sub.4            trans  (±)                                             NH.sub.4            trans  (+)                                                NH.sub.4            trans  (-)                                                MeNH.sub.3          cis    (+)                                                MeNH.sub.3          cis    (-)                                                MeNH.sub.3          trans  (+)                                                MeNH.sub.3          trans  (-)                                                .sup.i PrNH.sub.3   cis    (+)                                                .sup.i PrNH.sub.3   cis    (-)                                                .sup.i PrNH.sub.3   trans  (+)                                                .sup.i PrNH.sub.3   trans  (-)                                                Me                  cis    (+)                                                Me                  cis    (-)                                                Me                  trans  (+)                                                Et                  cis    (+)                                                Et                  cis    (-)                                                Et                  trans  (+)                                                Et                  trans  (-)                                                .sup.i Pr           cis    (+)                                                .sup.i Pr           cis    (-)                                                .sup.i Pr           trans  (+)                                                .sup.i Pr           trans  (-)                                                CH.sub.2 OMe        cis    (+)                                                CH.sub.2 OMe        cis    (-)                                                CH.sub.2 OMe        trans  (+)                                                CH.sub.2 OMe        trans  (-)                                                CH.sub.2 SMe        cis    (+)                                                CH.sub.2 SMe        cis    (-)                                                CH.sub.2 SMe        trans  (+)                                                CH.sub.2 SMe        trans  (-)                                                CH.sub.2 CHCH.sub.2 cis    (+)                                                CH.sub.2 CHCH.sub.2 cis    (-)                                                CH.sub.2 CHCH.sub.2 trans  (+)                                                CH.sub.2 CHCH.sub.2 trans  (-)                                                CH.sub.2 CCH        cis    (+)                                                CH.sub.2 CCH        cis    (-)                                                CH.sub.2 C CH       trans  (+)                                                CH.sub.2 CCH        trans  (-)                                                CH.sub.2 C.sub.6 H.sub.5                                                                          cis    (+)                                                CH.sub.2 C.sub.6 H.sub.5                                                                          cis    (-)                                                CH.sub.2 C.sub.6 H.sub.5                                                                          trans  (+)                                                CH.sub.2 C.sub.6 H.sub.5                                                                          trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                      cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                      cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                      trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                      trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                      cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                      cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                      trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                      trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                      cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                      cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                      trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                      trans  (- )                                               CH.sub.2 C.sub.6 H.sub.4Me-2                                                                      cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4Me-2                                                                      cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4Me-2                                                                      trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4Me-2                                                                      trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4Me-3                                                                      cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4Me-3                                                                      cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4Me-3                                                                      trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4Me-3                                                                      trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4Me-4                                                                      cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4Me-4                                                                      cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4Me-4                                                                      trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4Me-4                                                                      trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                     cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                     cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                     trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                     trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                     cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                     cis    (-)                                                 CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                    trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                     trans  (-)                                                CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                     cis    (+)                                                CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                     cis    (-)                                                CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                     trans  (+)                                                CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                     trans  (-)                                                CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                                 cis    (+)                                                CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                                 cis    (-)                                                CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                                 trans  (+)                                                CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                                 trans  (-)                                                ______________________________________                                         In the aforementioned Table 4, (±) represents non optical isomer, (+)      represents dextrorotatory optical isomer and (-) represents levorotatory      optical isomer.                                                               cis represents a cisform, trans represents a transform and mix. represent     a mixture of a cisform and a transform.                                       Me represents methyl group, Et represents ethyl group and .sup.i Pr           represents isopropyl group.                                              

                  TABLE 5                                                         ______________________________________                                        A compound of the general formula:                                             ##STR30##                                                                    In the below-mentioned table, Me represents methyl                            group, Et represents ethyl group, Pr represents propyl                        group, .sup.i Pr represents isopropyl group, Bu represents butyl              group, .sup.i Bu represents isobutyl group, .sup.s Bu represents              secondary butyl group, .sup.t Bu represents tertiary butyl                    group, cis represents a cis-form, trans represents a                          trans-form, mix. represents a mixture of a cis-form and                       a trans-form, 1 represents a single bond and 2 represents                     a double bond.                                                                (X).sub.m        R               R.sup.1                                                                             R.sup.2                                ______________________________________                                        --     1 (cis)   H               Me    Me                                     --     1 (cis)   Li              Me    Me                                     --     1 (cis)   Na              Me    Me                                     --     1 (cis)   K               Me    Me                                     --     1 (cis)   1/2Mg           Me    Me                                     --     1 (cis)   1/2Ca           Me    Me                                     --     1 (cis)   MeNH.sub.3      Me    Me                                     --     1 (cis)   EtNH.sub.3      Me    Me                                     --     1 (cis)   PrNH.sub.3      Me    Me                                     --     1 (cis)   .sup.i PrNH.sub.3                                                                             Me    Me                                     --     1 (cis)   NH.sub.2 CONH.sub.3                                                                           Me    Me                                     --     1 (cis)   Me              Me    Me                                     --     1 (cis)   Et              Me    Me                                     --     1 (cis)   .sup.i Pr       Me    Me                                     --     1 (cis)   Pr              Me    Me                                     --     1 (cis)   Bu              Me    Me                                     --     1 (cis)   .sup.i Bu       Me    Me                                     --     1 (cis)   .sup.s Bu       Me    Me                                     --     1 (cis)   .sup.t Bu       Me    Me                                     --     1 (cis)   CH.sub.2 OCH.sub.3                                                                            Me    Me                                     --     1 (cis)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                   Me    Me                                     --     1 (cis)   CH.sub.2 SCH.sub.3                                                                            Me    Me                                     --     1 (cis)   CH.sub.2 CHCH.sub.2                                                                           Me    Me                                     --     1 (cis)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                  Me    Me                                     --     1 (cis)   CH.sub.2 C CH.sub.2                                                                           Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.5                                                                      Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                  Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                  Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 Me    Me                                     --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 Me    Me                                     --     1 (cis)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             Me    Me                                     --     1 (cis)   H               OMe   OMe                                    --     1 (cis)   Li              OMe   OMe                                    --     1 (cis)   Na              OMe   OMe                                    --     1 (cis)   K               OMe   OMe                                    --     1 (cis)   1/2Mg           OMe   OMe                                    --     1 (cis)   1/2Ca           OMe   OMe                                    --     1 (cis)   MeNH.sub.3      OMe   OMe                                    --     1 (cis)   EtNH.sub.3      OMe   OMe                                    --     1 (cis)   PrNH.sub.3      OMe   OMe                                    --     1 (cis)   .sup.i PrNH.sub.3                                                                             OMe   OMe                                    --     1 (cis)   NH.sub.2 CONH.sub.3                                                                           OMe   OMe                                    --     1 (cis)   Me              OMe   OMe                                    --     1 (cis)   Et              OMe   OMe                                    --     1 (cis)   .sup.i Pr       OMe   OMe                                    --     1 (cis)   Pr              OMe   OMe                                    --     1 (cis)   Bu              OMe   OMe                                    --     1 (cis)   .sup.i Bu       OMe   OMe                                    --     1 (cis)   .sup.s Bu       OMe   OMe                                    --     1 (cis)   .sup.t Bu       OMe   OMe                                    --     1 (cis)   CH.sub.2 OCH.sub.3                                                                            OMe   OMe                                    --     1 (cis)   CH.sub.2 CH.sub.2 OCH.sub.3                                                                   OMe   OMe                                    --     1 (cis)   CH.sub.2 SCH.sub.3                                                                            OMe   OMe                                    --     1 (cis)   CH.sub.2 CHCH.sub.2                                                                           OMe   OMe                                    --     1 (cis)   C(CH.sub.3).sub.2 CHCH.sub.2                                                                  OMe   OMe                                    --     1 (cis)   CH.sub.2 CCH.sub.2                                                                            OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.5                                                                      OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                  OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                  OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 OMe   OMe                                    --     1 (cis)   CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 OMe   OMe                                    --     1 (cis)   CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             OMe   OMe                                    --     1 (trans) H               Me    Me                                     --     1 (trans) Li              Me    Me                                     --     1 (trans) Na              Me    Me                                     --     1 (trans) K               Me    Me                                     --     1 (trans) 1/2Mg           Me    Me                                     --     1 (trans) 1/2Ca           Me    Me                                     --     1 (trans) MeNH.sub.3      Me    Me                                     --     1 (trans) EtNH.sub.3      Me    Me                                     --     1 (trans) PrNH.sub.3      Me    Me                                     --     1 (trans) .sup.i PrNH.sub.3                                                                             Me    Me                                     --     1 (trans) NH.sub.2 CONH.sub.3                                                                           Me    Me                                     --     1 (trans) Me              Me    Me                                     --     1 (trans) Et              Me    Me                                     --     1 (trans) .sup.i Pr       Me    Me                                     --     1 (trans) Pr              Me    Me                                     --     1 (trans) Bu              Me    Me                                     --     1 (trans) .sup.i Bu       Me    Me                                     --     1 (trans) .sup.s Bu       Me    Me                                     --     1 (trans) .sup.t Bu       Me    Me                                     --     1 (trans) CH.sub.2 OCH.sub.3                                                                            Me    Me                                     --     1 (trans) CH.sub.2 CH.sub.2 OCH.sub.3                                                                   Me    Me                                     --     1 (trans) CH.sub.2 SCH.sub.3                                                                            Me    Me                                     --     1 (trans) CH.sub.2 CHCH.sub.2                                                                           Me    Me                                     --     1 (trans) C(CH.sub.3).sub.2 CHCH.sub.2                                                                  Me    Me                                     --     1 (trans) CH.sub.2 CCH.sub.2                                                                            Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.5                                                                      Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                  Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                  Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 Me    Me                                     --     1 (trans) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 Me    Me                                     --     1 (trans) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             Me    Me                                     --     1 (trans) H               OMe   OMe                                    --     1 (trans) Li              OMe   OMe                                    --     1 (trans) Na              OMe   OMe                                    --     1 (trans) K               OMe   OMe                                    --     1 (trans) 1/2Mg           OMe   OMe                                    --     1 (trans) 1/2Ca           OMe   OMe                                    --     1 (trans) MeNH.sub.3      OMe   OMe                                    --     1 (trans) EtNH.sub.3      OMe   OMe                                    --     1 (trans) PrNH.sub.3      OMe   OMe                                    --     1 (trans) .sup.i PrNH.sub.3                                                                             OMe   OMe                                    --     1 (trans) NH.sub.2 CONH.sub.3                                                                           OMe   OMe                                    --     1 (trans) Me              OMe   OMe                                    --     1 (trans) Et              OMe   OMe                                    --     1 (trans) .sup.i Pr       OMe   OMe                                    --     1 (trans) Pr              OMe   OMe                                    --     1 (trans) Bu              OMe   OMe                                    --     1 (trans) .sup.i Bu       OMe   OMe                                    --     1 (trans) .sup.s Bu       OMe   OMe                                    --     1 (trans) .sup.t Bu       OMe   OMe                                    --     1 (trans) CH.sub.2 OCH.sub.3                                                                            OMe   OMe                                    --     1 (trans) CH.sub.2 CH.sub.2 OCH.sub.3                                                                   OMe   OMe                                    --     1 (trans) CH.sub.2 SCH.sub.3                                                                            OMe   OMe                                    --     1 (trans) CH.sub.2 CHCH.sub.2                                                                           OMe   OMe                                    --     1 (trans) C(CH.sub.3).sub.2 CHCH.sub.2                                                                  OMe   OMe                                    --     1 (trans) CH.sub.2 CCH.sub.2                                                                            OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.5                                                                      OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4 Cl-2                                                                 OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                  OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 OMe   OMe                                    --     1 (trans) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 OMe   OMe                                    --     1 (trans) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             OMe   OMe                                    --     1 (mixt.) H               Me    Me                                     --     1 (mixt.) Li              Me    Me                                     --     1 (mixt.) Na              Me    Me                                     --     1 (mixt.) K               Me    Me                                     --     1 (mixt.) 1/2Mg           Me    Me                                     --     1 (mixt.) 1/2Ca           Me    Me                                     --     1 (mixt.) MeNH.sub.3      Me    Me                                     --     1 (mixt.) EtNH.sub.3      Me    Me                                     --     1 (mixt.) PrNH.sub.3      Me    Me                                     --     1 (mixt.) .sup.i PrNH.sub.3                                                                             Me    Me                                     --     1 (mixt.) NH.sub.2 CONH.sub.3                                                                           Me    Me                                     --     1 (mixt.) Me              Me    Me                                     --     1 (mixt.) Et              Me    Me                                     --     1 (mixt.) .sup.i Pr       Me    Me                                     --     1 (mixt.) Pr              Me    Me                                     --     1 (mixt.) Bu              Me    Me                                     --     1 (mixt.) .sup.i Bu       Me    Me                                     --     1 (mixt.) .sup.s Bu       Me    Me                                     --     1 (mixt.) .sup.t Bu       Me    Me                                     --     1 (mixt.) CH.sub.2 OCH.sub.3                                                                            Me    Me                                     --     1 (mixt.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                   Me    Me                                     --     1 (mixt.) CH.sub.2 SCH.sub.3                                                                            Me    Me                                     --     1 (mixt.) CH.sub.2 CHCH.sub.2                                                                           Me    Me                                     --     1 (mixt.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                  Me    Me                                     --     1 (mixt.) CH.sub.2 CCH.sub.2                                                                            Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.5                                                                      Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                  Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                  Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 Me    Me                                     --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 Me    Me                                     --     1 (mixt.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             Me    Me                                     --     1 (mixt.) H               OMe   OMe                                    --     1 (mixt.) Li              OMe   OMe                                    --     1 (mixt.) Na              OMe   OMe                                    --     1 (mixt.) K               OMe   OMe                                    --     1 (mixt.) 1/2Mg           OMe   OMe                                    --     1 (mixt.) 1/2Ca           OMe   OMe                                    --     1 (mixt.) MeNH.sub.3      OMe   OMe                                    --     1 (mixt.) EtNH.sub.3      OMe   OMe                                    --     1 (mixt.) PrNH.sub.3      OMe   OMe                                    --     1 (mixt.) .sup.i PrNH.sub.3                                                                             OMe   OMe                                    --     1 (mixt.) NH.sub.2 CONH.sub.3                                                                           OMe   OMe                                    --     1 (mixt.) Me              OMe   OMe                                    --     1 (mixt.) Et              OMe   OMe                                    --     1 (mixt.) .sup.i Pr       OMe   OMe                                    --     1 (mixt.) Pr              OMe   OMe                                    --     1 (mixt.) Bu              OMe   OMe                                    --     1 (mixt.) .sup.i Bu       OMe   OMe                                    --     1 (mixt.) .sup.s Bu       OMe   OMe                                    --     1 (mixt.) .sup.t Bu       OMe   OMe                                    --     1 (mixt.) CH.sub.2 OCH.sub.3                                                                            OMe   OMe                                    --     1 (mixt.) CH.sub.2 CH.sub.2 OCH.sub.3                                                                   OMe   OMe                                    --     1 (mixt.) CH.sub.2 SCH.sub.3                                                                            OMe   OMe                                    --     1 (mixt.) CH.sub.2 CHCH.sub.2                                                                           OMe   OMe                                    --     1 (mixt.) C(CH.sub.3).sub.2 CHCH.sub.2                                                                  OMe   OMe                                    --     1 (mixt.) CH.sub.2 CCH.sub.2                                                                            OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.5                                                                      OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                  OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                  OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 OMe   OMe                                    --     1 (mixt.) CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 OMe   OMe                                    --     1 (mixt.) CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             OMe   OMe                                    --     2 (--)    H               Me    Me                                     --     2 (--)    Li              Me    Me                                     --     2 (--)    Na              Me    Me                                     --     2 (--)    K               Me    Me                                     --     2 (--)    1/2Mg           Me    Me                                     --     2 (--)    1/2Ca           Me    Me                                     --     2 (--)    MeNH.sub.3      Me    Me                                     --     2 (--)    EtNH.sub.3      Me    Me                                     --     2 (--)    PrNH.sub.3      Me    Me                                     --     2 (--)    .sup.i PrNH.sub.3                                                                             Me    Me                                     --     2 (--)    NH.sub. 2 CONH.sub.3                                                                          Me    Me                                     --     2 (--)    Me              Me    Me                                     --     2 (--)    Et              Me    Me                                     --     2 (--)    .sup.i Pr       Me    Me                                     --     2 (--)    Pr              Me    Me                                     --     2 (--)    Bu              Me    Me                                     --     2 (--)    .sup.i Bu       Me    Me                                     --     2 (--)    .sup.s Bu       Me    Me                                     --     2 (--)    .sup.t Bu       Me    Me                                     --     2 (--)    CH.sub.2 OCH.sub.3                                                                            Me    Me                                     --     2 (--)    CH.sub.2 CH.sub.2 OCH.sub.3                                                                   Me    Me                                     --     2 (--)    CH.sub.2 SCH.sub.3                                                                            Me    Me                                     --     2 (--)    CH.sub.2 CHCH.sub.2                                                                           Me    Me                                     --     2 (--)    C(CH.sub.3).sub.2 CHCH.sub.2                                                                  Me    Me                                     --     2 (--)    CH.sub.2 CCH.sub.2                                                                            Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.5                                                                      Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                  Me    Me                                     --     2 (--)     CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                 Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 Me    Me                                     --     2 (--)    CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 Me    Me                                     --     2 (--)    CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             Me    Me                                     --     2 (--)    H               OMe   OMe                                    --     2 (--)    Li              OMe   OMe                                    --     2 (--)    Na              OMe   OMe                                    --     2 (--)    K               OMe   OMe                                    --     2 (--)    1/2Mg           OMe   OMe                                    --     2 (--)    1/2Ca           OMe   OMe                                    --     2 (--)    MeNH.sub.3      OMe   OMe                                    --     2 (--)    EtNH.sub.3      OMe   OMe                                    --     2 (--)    PrNH.sub.3      OMe   OMe                                    --     2 (--)    .sup.i PrNH.sub.3                                                                             OMe   OMe                                    --     2 (--)    NH.sub.2 CONH.sub.3                                                                           OMe   OMe                                    --     2 (--)    Me              OMe   OMe                                    --     2 (--)    Et              OMe   OMe                                    --     2 (--)    .sup.i Pr       OMe   OMe                                    --     2 (--)    Pr              OMe   OMe                                    --     2 (--)    Bu              OMe   OMe                                    --     2 (--)    .sup.i Bu       OMe   OMe                                    --     2 (--)    .sup.s Bu       OMe   OMe                                    --     2 (--)    .sup.t Bu       OMe   OMe                                    --     2 (--)    CH.sub.2 OCH.sub.3                                                                            OMe   OMe                                    --     2 (--)    CH.sub.2 CH.sub.2 OCH.sub.3                                                                   OMe   OMe                                    --     2 (--)    CH.sub.2 SCH.sub.3                                                                            OMe   OMe                                    --     2 (--)    CH.sub.2 CHCH.sub.2                                                                           OMe   OMe                                    --     2 (--)    C(CH.sub.3).sub.2 CHCH.sub.2                                                                  OMe   OMe                                    --     2 (--)    CH.sub.2 CCH.sub.2                                                                            OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub. 5                                                                     OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Cl-2                                                                  OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Cl-3                                                                  OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Cl-4                                                                  OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Me-2                                                                  OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Me-3                                                                  OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4Me-4                                                                  OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4OMe-2                                                                 OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4OMe-3                                                                 OMe   OMe                                    --     2 (--)    CH.sub.2 C.sub.6 H.sub.4OMe-4                                                                 OMe   OMe                                    --     2 (--)    CH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                             OMe   OMe                                    ______________________________________                                    

    __________________________________________________________________________    Compound No. of                                                               the Invention                                                                          Formula            Physical data                                     __________________________________________________________________________              ##STR31##         Liquid n.sub.D.sup.20 1.5303                      2                                                                                       ##STR32##         Liquid n.sub.D.sup.20 1.5090                               (trans-form)                                                         3                                                                                       ##STR33##         Liquid n.sub.D.sup.20 1.5081                               (cis-form)                                                           4                                                                                       ##STR34##         Liquid n.sub.D.sup.20 1.5078                      5                                                                                       ##STR35##         Liquid                                            6                                                                                       ##STR36##         Liquid                                                     (mixture of cis-form and                                                      trans-form)                                                          7                                                                                       ##STR37##         Liquid n.sub.D.sup.20 1.5104                               (cis-form)                                                           8                                                                                       ##STR38##         Liquid n.sub.D.sup.19 1.5052                               (cis-form)                                                           9                                                                                       ##STR39##         Liquid n.sub.D.sup.19.5 1.5060                             (trans-form)                                                         10                                                                                      ##STR40##         Liquid n.sub.D.sup.19 1.5035                               (trans-form)                                                         11                                                                                      ##STR41##         Liquid [α].sub.D.sup.23.3 +8.34 (C =                                    1.030, CHCl.sub.3)                                         (cis(+)-form)                                                        12                                                                                      ##STR42##         Liquid [α].sub.D.sup.23.3 -7.72 (C =                                    1.165, CHCl.sub.3)                                         (cis(-)-form)                                                        13                                                                                      ##STR43##         Liquid [α].sub.D.sup.23.4 +17.94 (C =                                   1.287, CHCl.sub.3)                                         (trans(+)-form)                                                      14                                                                                      ##STR44##         Liquid [α].sub.D.sup.23.4 -22.91 (C =                                   1.008, CHCl.sub.3)                                         (trans(-)-form)                                                      15                                                                                      ##STR45##         Semi-crystal                                      16                                                                                      ##STR46##         Liquid n.sub.D.sup.21.5 1.5443                    17                                                                                      ##STR47##         Crystal m.p. 120.0˜123.0° C.                  (cis-form)                                                           18                                                                                      ##STR48##         Crystal m.p. 82.0˜84.0° C.                    (trans-form)                                                         19                                                                                      ##STR49##         Liquid n.sub.D.sup.20 1.4955                      20                                                                                      ##STR50##         n.sub.D.sup.21 1.4928                             21                                                                                      ##STR51##         Liquid n.sub.D.sup.21 1.5048                      22                                                                                      ##STR52##         Liquid n.sub.D.sup.20 1.5115                      23                                                                                      ##STR53##         Liquid n.sub.D.sup.20 1.5128                      __________________________________________________________________________

                                      TABLE 7                                     __________________________________________________________________________       Application                                                                         Echinochoa                                                                           Digitaria                                                                           Cyperus                                                                            Solanum                                                                            Galinsoga                                                                           Rorippa                                 No.                                                                              rate g/a                                                                            crus galli                                                                           adscendens                                                                          microiria                                                                          nigrum                                                                             ciliate                                                                             indica                                                                             Cotton                             __________________________________________________________________________     1 6.3   4      4     4    4    3     5    0                                   2 1.6   5      5     5    5    4     5    0                                     3.2   5      5     5    5    5     5    0                                     6.3   5      5     5    5    5     5    1                                   3 6.3   4      4     5    4    5     5    0                                   4 25    4      4     5    5    3     5    0                                   5 1.6   4      4     5    4    3     4    0                                     3.2   5      5     5    5    4     5    0                                     6.3   5      5     5    5    5     5    0                                   6 1.6   4      4     5    5    3     5    0                                     3.2   5      5     5    5    4     5    0                                     6.3   5      5     5    5    5     5    1                                   7 1.6   4      4     5    5    3     5    --                                    3.2   5      5     5    5    4     5    --                                    6.3   5      5     5    5    5     5    --                                   8                                                                              6.3   5      5     5    5    5     5    1                                   9 1.6   5      5     5    5    5     5    0                                     3.2   5      5     5    5    5     5    1                                     6.3   5      5     5    5    5     5    2                                  10 1.6   5      5     5    5    5     5    0                                     3.2   5      5     5    5    5     5    1                                     6.3   5      5     5    5    5     5    2                                  11 6.3   5      5     5    5    4     5    0                                  12 6.3   5      5     5    5    4     5    0                                  13 1.6   5      5     5    5    5     5    0                                  14 6.3   5      5     5    5    5     5    0                                  16 6.3   4      4     5    5    4     5    0                                  18 25    4      4     5    4    3     5    0                                  19 25    5      5     5    5    4     5    0                                  20 25    4      4     5    4    3     5    0                                  22 25    4      4     4    5    3     5    0                                  23 6.3   5      5     5    5    4     5    0                                  __________________________________________________________________________

                                      TABLE 8                                     __________________________________________________________________________       Application                                                                         Echinochoa                                                                           Digitaria                                                                           Cyperus                                                                            Solanum                                                                            Galinsoga                                                                           Rorippa                                 No.                                                                              rate g/a                                                                            crus galli                                                                           adscendens                                                                          microiria                                                                          nigrum                                                                             ciliate                                                                             indica                                                                             Cotton                             __________________________________________________________________________     1 6.3   3      4     5    5    2     5    1                                   2 6.3   4      4     5    5    3     5    0                                   3 6.3   3      3     4    5    2     5    0                                   4 25    3      4     5    5    2     5    0                                   5 6.3   4      4     4    5    4     5    0                                   6 1.6   4      4     5    5    2     5    0                                     3.2   5      5     5    5    3     5    1                                     6.3   5      5     5    5    4     5    2                                   7 1.6   5      4     5    5    3     5    0                                     3.2   5      5     5    5    4     5    1                                     6.3   5      5     5    5    5     5    2                                   8 6.3   5      4     5    5    4     5    0                                   9 1.6   5      5     5    5    4     5    1                                     3.2   5      5     5    5    5     5    2                                     6.3   5      5     5    5    5     5    3                                  10 1.6   5      5     5    5    4     5    1                                     3.2   5      5     5    5    5     5    2                                     6.3   5      5     5    5    5     5    3                                  11 6.3   5      5     5    5    4     5    0                                  12 6.3   5      5     5    5    4     5    0                                  13 1.6   5      5     5    5    5     5    0                                  14 6.3   5      5     5    5    5     5    0                                  16 6.3   4      3     5    5    3     4    0                                  18 25    3      4     4    5    2     4    0                                  19 25    5      5     5    5    5     5    0                                  20 25    3      4     5    5    3     4    0                                  22 25    4      4     5    5    3     4    0                                  23 6.3   5      4     5    5    3     5    0                                  __________________________________________________________________________

What is claimed is:
 1. A pyrimidine compound or an optical isomerthereof a formula (I): ##STR54## where W represents an oxygen atom or asulfur atom;X represents a lower alkyl group or a lower alkoxycarbonylgroup; R represents a hydrogen atom; a lower alkyl group optionallysubstituted by at least one substituent selected from a halogen atom, alower alkoxy group or a lower alkylthio group, or a phenyl groupoptionally substituted by a halogen atom, a lower alkyl group, a loweralkoxy group or a lower alkylthio group; a lower alkenyl groupoptionally substituted by at least one substituent selected from ahalogen atom, a lower alkoxy group or a lower alkylthio group, or aphenyl group optionally substituted by a halogen atom, a lower alkylgroup, a lower alkoxy group or a lower alkylthio group; a lower alkynylgroup optionally substituted by at least one substituent selected from ahalogen atom, a lower alkoxy group or a lower alkylthio group, or aphenyl group optionally substituted by a halogen atom, a lower alkylgroup, a lower alkoxy group or a lower alkylthio group; an alkali metal,an alkaline earth metal or an optionally substituted ammonium cation; R¹and R² may be the same or different and each represents a halogen atom;a lower alkyl group optionally substituted by at least one substituentselected from a halogen atom, a lower alkoxy group or a lower alkylthiogroup; or a lower alkoxy group optionally substituted by at least onesubstituent selected from a halogen atom, a lower alkoxy group or alower alkylthio group; n represents an integer of from 3 to 5; mrepresents an integer of from 0 to 2; and represents a single bond or adouble bond.
 2. A herbicidal composition comprising a herbicidallyeffective amount of a compound as claimed in claim 1, and a carrier.